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    TTI1 Tti1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853834, updated on 27-Dec-2024

    Summary

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    Official Symbol
    TTI1
    Official Full Name
    Tti1p
    Primary source
    SGD:S000001516
    Locus tag
    YKL033W
    See related
    AllianceGenome:SGD:S000001516; FungiDB:YKL033W; VEuPathDB:YKL033W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to be involved in chromatin organization. Located in mitochondrion. Part of TTT Hsp90 cochaperone complex. Used to study cancer. Orthologous to human TTI1 (TELO2 interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TTI1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (375456..378572)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene ubiquitin-protein ligase TUL1 Neighboring gene putative hydrolase Neighboring gene tRNA-Val Neighboring gene DNA-binding transcription repressor IXR1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Essentiality of Sis1, a J-domain protein Hsp70 cochaperone, can be overcome by Tti1, a specialized PIKK chaperone. Schilke BA, et al. Mol Biol Cell, 2022 Mar 1. PMID 34935410, Free PMC Article
    2. Saccharomyces cerevisiae Tel2 plays roles in TORC signaling and telomere maintenance that can be mutationally separated. Rozario D, et al. Biochem Biophys Res Commun, 2012 Jan 27. PMID 22227188
    3. Functional Diversity of Haloacid Dehalogenase Superfamily Phosphatases from Saccharomyces cerevisiae: BIOCHEMICAL, STRUCTURAL, AND EVOLUTIONARY INSIGHTS. Kuznetsova E, et al. J Biol Chem, 2015 Jul 24. PMID 26071590, Free PMC Article
    4. Identification of the novel TRAPP associated protein Tca17. Montpetit B, et al. Traffic, 2009 Jun. PMID 19220810
    5. Mass-murdering: deletion of twenty-three ORFs from Saccharomyces cerevisiae chromosome XI reveals five genes essential for growth and three genes conferring detectable mutant phenotype. Wysocki R, et al. Gene, 1999 Mar 18. PMID 10095102

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Essentiality of Sis1, a J-domain protein Hsp70 cochaperone, can be overcome by Tti1, a specialized PIKK chaperone.
      Title: Essentiality of Sis1, a J-domain protein Hsp70 cochaperone, can be overcome by Tti1, a specialized PIKK chaperone.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of TTT Hsp90 cochaperone complex HDA PubMed 
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tti1p
    NP_012892.1
    • Subunit of the TTT complex and regulator of telomere length; subunit of the TTT Hsp90 cochaperone complex that is involved in chromatin remodeling and telomeric chromatin regulation; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1; detected in mitochondria and the cytoplasm in high-throughput studies; similar to S. pombe Tti1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      375456..378572
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179599.1 → NP_012892.1  TPA: Tti1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012892.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXQ3, P36097
      UniProtKB/TrEMBL
      B5VMC1, G2WHZ8, N1P0B6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36097.1

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