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    CG17528 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3355134, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG17528provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261387
    Locus tag
    Dmel_CG17528
    See related
    AllianceGenome:FB:FBgn0261387
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CAMK-like; CG40283; Dmel\CG17528; Pk1; PK1; zyg8
    Summary
    Predicted to enable calcium-dependent protein serine/threonine kinase activity; calcium/calmodulin-dependent protein kinase activity; and calmodulin binding activity. Predicted to be involved in intracellular signal transduction. Predicted to be active in cytoplasm and nucleus. Is expressed in adult head. Human ortholog(s) of this gene implicated in X-linked lissencephaly 1 and subcortical band heterotopia. Orthologous to several human genes including DCLK1 (doublecortin like kinase 1) and DCLK2 (doublecortin like kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG17528 in Genome Data Viewer
    Location:
    41C2-41C2; 2-55 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (4815426..4824319, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (702931..711824, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46478 Neighboring gene long non-coding RNA:CR46476 Neighboring gene long non-coding RNA:CR46477 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PK1 from Drosophila obscurin is an inactive pseudokinase with scaffolding properties. Zacharchenko T, et al. Open Biol, 2023 Apr. PMID 37121260, Free PMC Article
    2. Atypical cadherin, Fat2, regulates axon terminal organization in the developing Drosophila olfactory receptor neurons. Vien KM, et al. iScience, 2024 Jul 19. PMID 39055932, Free PMC Article
    3. A systematic analysis of microtubule-destabilizing factors during dendrite pruning in Drosophila. Bu S, et al. EMBO Rep, 2021 Oct 5. PMID 34338441, Free PMC Article
    4. Conundrum, an ARHGAP18 orthologue, regulates RhoA and proliferation through interactions with Moesin. Neisch AL, et al. Mol Biol Cell, 2013 May. PMID 23468526, Free PMC Article
    5. The Green Valley of Drosophila melanogaster Constitutive Heterochromatin: Protein-Coding Genes Involved in Cell Division Control. Messina G, et al. Cells, 2022 Sep 29. PMID 36231024, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PK1 from Drosophila obscurin is an inactive pseudokinase with scaffolding properties.
      Title: PK1 from Drosophila obscurin is an inactive pseudokinase with scaffolding properties.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c4820121-4820010 mobile_element_type = transposon:INE-1{}4409
    • Loc: c4822526-4822404 mobile_element_type = transposon:INE-1{}4410
    • Loc: c4822959-4822848 mobile_element_type = transposon:INE-1{}4426
    • Loc: c4823083-4823042 mobile_element_type = transposon:INE-1{}4429

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium/calmodulin-dependent protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG17528-PC
    CG17528-PD
    protein kinase 1
    NP_001036462.1
    NP_001036463.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      4815426..4824319 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042997.2 → NP_001036462.1  uncharacterized protein Dmel_CG17528, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036462.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24057, Q7PLI6, Q7PLI7, Q8SWT6
      Conserved Domains (3) summary
      smart00220
      Location:477 → 734
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00537
      Location:153 → 244
      DCX; Domain in the Doublecortin (DCX) gene product
      cl21453
      Location:477 → 734
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001042998.2 → NP_001036463.1  uncharacterized protein Dmel_CG17528, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036463.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24057, Q7PLI6, Q7PLI7, Q8SWT6
      Conserved Domains (3) summary
      smart00220
      Location:477 → 734
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00537
      Location:153 → 244
      DCX; Domain in the Doublecortin (DCX) gene product
      cl21453
      Location:477 → 734
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7PLI7.1 Q7PLI7

    Gene LinkOut

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