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    SERPINB2 serpin family B member 2 [ Homo sapiens (human) ]

    Gene ID: 5055, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SERPINB2provided by HGNC
    Official Full Name
    serpin family B member 2provided by HGNC
    Primary source
    HGNC:HGNC:8584
    See related
    Ensembl:ENSG00000197632 MIM:173390; AllianceGenome:HGNC:8584
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAI; PAI2; PAI-2; PLANH2; HsT1201
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in fibrinolysis and negative regulation of apoptotic process. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in cornified envelope and extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in esophagus (RPKM 112.4), skin (RPKM 35.4) and 2 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SERPINB2 in Genome Data Viewer
    Location:
    18q21.33-q22.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (63887705..63903888)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (64092785..64108961)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (61554939..61571122)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904318 Neighboring gene serpin family B member 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13469 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:61536385-61537584 Neighboring gene uncharacterized LOC124904356 Neighboring gene serpin family B member 10 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:61607430-61607930 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9531 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13470 Neighboring gene uncharacterized LOC105372165 Neighboring gene histocompatibility minor serpin domain containing

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Plasminogen-activator inhibitor type 2 (PAI-2) is a spontaneously polymerising SERPIN. Biochemical characterisation of the recombinant intracellular and extracellular forms. Mikus P, et al. Eur J Biochem, 1993 Dec 15. PMID 7506655
    2. SERPINB2 is regulated by dynamic interactions with pause-release proteins and enhancer RNAs. Shii L, et al. Mol Immunol, 2017 Aug. PMID 28578223, Free PMC Article
    3. Plasminogen activator inhibitor 2. Isolation and characterization of the promoter region of the gene. Kruithof EK, et al. Biochem Biophys Res Commun, 1988 Oct 14. PMID 2845977
    4. Plasminogen activator inhibitor type 2: a regulator of monocyte proliferation and differentiation. Yu H, et al. Blood, 2002 Apr 15. PMID 11929770
    5. Down-regulation of SerpinB2 is associated with gefitinib resistance in non-small cell lung cancer and enhances invadopodia-like structure protrusions. Bae SY, et al. Sci Rep, 2016 Aug 25. PMID 27558531, Free PMC Article

    See all (141) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Serpin Family B Member 2 Polymorphisms in Patients with Diabetic Kidney Disease: An Association Study.
      Title: Serpin Family B Member 2 Polymorphisms in Patients with Diabetic Kidney Disease: An Association Study.
    2. Plasminogen activator inhibitor-2 and impaired fibrinolysis in pregnancy and sickle cell anemia.
      Title: Plasminogen activator inhibitor-2 and impaired fibrinolysis in pregnancy and sickle cell anemia.
    3. Estetrol/GPER/SERPINB2 transduction signaling inhibits the motility of triple-negative breast cancer cells.
      Title: Estetrol/GPER/SERPINB2 transduction signaling inhibits the motility of triple-negative breast cancer cells.
    4. miR-450b promotes cell migration and invasion by inhibiting SERPINB2 in oral squamous cell carcinoma.
      Title: miR-450b promotes cell migration and invasion by inhibiting SERPINB2 in oral squamous cell carcinoma.
    5. SERPINB2, an Early Responsive Gene to Epigallocatechin Gallate, Inhibits Migration and Promotes Apoptosis in Esophageal Cancer Cells.
      Title: SERPINB2, an Early Responsive Gene to Epigallocatechin Gallate, Inhibits Migration and Promotes Apoptosis in Esophageal Cancer Cells.
    6. Unveiling a novel serpinB2-tripeptidyl peptidase II signaling axis during senescence.
      Title: Unveiling a novel serpinB2-tripeptidyl peptidase II signaling axis during senescence.
    7. A Novel Role for Plasminogen Activator Inhibitor Type-2 as a Hypochlorite-Resistant Serine Protease Inhibitor and Holdase Chaperone.
      Title: A Novel Role for Plasminogen Activator Inhibitor Type-2 as a Hypochlorite-Resistant Serine Protease Inhibitor and Holdase Chaperone.
    8. HMSC-Derived Exosome Inhibited Th2 Cell Differentiation via Regulating miR-146a-5p/SERPINB2 Pathway.
      Title: HMSC-Derived Exosome Inhibited Th2 Cell Differentiation via Regulating miR-146a-5p/SERPINB2 Pathway.
    9. HKB99, an allosteric inhibitor of phosphoglycerate mutase 1, suppresses invasive pseudopodia formation and upregulates plasminogen activator inhibitor-2 in erlotinib-resistant non-small cell lung cancer cells.
      Title: HKB99, an allosteric inhibitor of phosphoglycerate mutase 1, suppresses invasive pseudopodia formation and upregulates plasminogen activator inhibitor-2 in erlotinib-resistant non-small cell lung cancer cells.
    10. SERPINB2-its regulation and interplay with aryl hydrocarbon receptor.
      Title: SERPINB2-its regulation and interplay with aryl hydrocarbon receptor.
    Submit: New GeneRIF Correction See all GeneRIFs (84)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of serpin peptidase inhibitor, clade B, member 2 (SERPINB2) in human B cells PubMed
    env HIV-1 infection and HIV-1 gp120 treatment of human peripheral blood mononuclear cells result in induction of SerpinB2 and this induction enhances transcription from the HIV-1 LTR PubMed
    Tat tat HIV-1 Tat upregulates the expression of serpin peptidase inhibitor, clade B, member 2 (SERPINB2) in human primary T cells PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of serpin peptidase inhibitor, clade B2 (SERPINB2) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase inhibitor activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in fibrinolysis TAS
    Traceable Author Statement
    more info
    		  
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cornified envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    plasminogen activator inhibitor 2
    Names
    monocyte Arg-serpin
    placental plasminogen activator inhibitor
    plasminogen activator inhibitor, type II (arginine-serpin)
    plasminogen-activator inhibitor
    serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2
    serpin B2
    serpin peptidase inhibitor, clade B (ovalbumin), member 2
    urokinase inhibitor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001143818.2 → NP_001137290.1  plasminogen activator inhibitor 2

      See identical proteins and their annotated locations for NP_001137290.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC072051, CD366374, DA543366, DQ656059
      Consensus CDS
      CCDS11989.1
      UniProtKB/Swiss-Prot
      P05120, Q96E96
      UniProtKB/TrEMBL
      B2R7Y0
      Related
      ENSP00000401645.1, ENST00000457692.5
      Conserved Domains (1) summary
      cd02058
      Location:4 → 415
      PAI-2; Plasminogen Activator Inhibitor-2 (PAI-2). PAI-2 is a serine protease inhibitor that belongs to the ov-serpin branch of the serpin superfamily. It is is an effective inhibitor of urinary plasminogen activator (urokinase or uPA) and is involved in cell ...

    2. NM_002575.3 → NP_002566.1  plasminogen activator inhibitor 2

      See identical proteins and their annotated locations for NP_002566.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC072051, BC012609, CD366374
      Consensus CDS
      CCDS11989.1
      UniProtKB/Swiss-Prot
      P05120, Q96E96
      UniProtKB/TrEMBL
      B2R7Y0
      Related
      ENSP00000299502.4, ENST00000299502.9
      Conserved Domains (1) summary
      cd02058
      Location:4 → 415
      PAI-2; Plasminogen Activator Inhibitor-2 (PAI-2). PAI-2 is a serine protease inhibitor that belongs to the ov-serpin branch of the serpin superfamily. It is is an effective inhibitor of urinary plasminogen activator (urokinase or uPA) and is involved in cell ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      63887705..63903888
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024451192.2 → XP_024306960.1  plasminogen activator inhibitor 2 isoform X1

      UniProtKB/Swiss-Prot
      P05120, Q96E96
      UniProtKB/TrEMBL
      B2R7Y0
      Conserved Domains (1) summary
      cd02058
      Location:4 → 415
      PAI-2; Plasminogen Activator Inhibitor-2 (PAI-2). PAI-2 is a serine protease inhibitor that belongs to the ov-serpin branch of the serpin superfamily. It is is an effective inhibitor of urinary plasminogen activator (urokinase or uPA) and is involved in cell ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      64092785..64108961
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054318676.1 → XP_054174651.1  plasminogen activator inhibitor 2 isoform X1

      UniProtKB/TrEMBL
      B2R7Y0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05120.2 GenPept UniProtKB/Swiss-Prot:P05120

    Gene LinkOut

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