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    MET MET proto-oncogene, receptor tyrosine kinase [ Homo sapiens (human) ]

    Gene ID: 4233, updated on 10-Dec-2024

    Summary

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    Official Symbol
    METprovided by HGNC
    Official Full Name
    MET proto-oncogene, receptor tyrosine kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:7029
    See related
    Ensembl:ENSG00000105976 MIM:164860; AllianceGenome:HGNC:7029
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DA11; HGFR; AUTS9; RCCP2; c-Met; DFNB97
    Summary
    This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]
    Expression
    Broad expression in placenta (RPKM 12.8), liver (RPKM 11.3) and 20 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MET in Genome Data Viewer
    Location:
    7q31.2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (116672196..116798377)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (117987305..118113574)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (116312250..116438431)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4219 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26533 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26534 Neighboring gene Sharpr-MPRA regulatory region 9016 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18557 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18558 Neighboring gene Sharpr-MPRA regulatory region 15503 Neighboring gene caveolin 2 Neighboring gene caveolin 1 Neighboring gene Sharpr-MPRA regulatory region 6449 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18559 Neighboring gene greater CFTR locus negative regulatory element NR2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26535 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26536 Neighboring gene cytosolic oncogenic antisense to MET transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26537 Neighboring gene MPRA-validated peak6696 silencer Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:116273493-116274692 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18560 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18561 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18562 Neighboring gene greater CFTR locus negative regulatory element CR3 Neighboring gene greater CFTR locus negative regulatory element CR5 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:116363882-116365081 Neighboring gene uncharacterized LOC124901824 Neighboring gene greater CFTR locus negative regulatory element CR6 Neighboring gene greater CFTR locus negative regulatory element CR8 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:116412324-116413523 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:116416081-116417280 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:116420832-116421760 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:116421761-116422688 Neighboring gene uncharacterized LOC124901731 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:116496945-116497602 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:116502260-116503022 Neighboring gene RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing pseudogene Neighboring gene capping actin protein of muscle Z-line subunit alpha 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. c-Met is a prognostic marker and potential therapeutic target in clear cell renal cell carcinoma. Gibney GT, et al. Ann Oncol, 2013 Feb. PMID 23022995, Free PMC Article
    2. Overexpression of hepatocyte growth factor receptor in scleroderma dermal fibroblasts is caused by autocrine transforming growth factor β signaling. Kajihara I, et al. Biosci Trends, 2012 Jun. PMID 22890162
    3. [c-MET Oncogene in Renal Cell Carcinomas]. Erlmeier F, et al. Aktuelle Urol, 2016 Dec. PMID 28006830
    4. Genomic amplification of MET with boundaries within fragile site FRA7G and upregulation of MET pathways in esophageal adenocarcinoma. Miller CT, et al. Oncogene, 2006 Jan 19. PMID 16186806
    5. Autism-associated promoter variant in MET impacts functional and structural brain networks. Rudie JD, et al. Neuron, 2012 Sep 6. PMID 22958829, Free PMC Article

    See all (1416) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The PTPRZ1-MET/STAT3/ISG20 axis in glioma stem-like cells modulates tumor-associated macrophage polarization.
      Title: The PTPRZ1-MET/STAT3/ISG20 axis in glioma stem-like cells modulates tumor-associated macrophage polarization.
    2. Single-molecule imaging and molecular dynamics simulations reveal early activation of the MET receptor in cells.
      Title: Single-molecule imaging and molecular dynamics simulations reveal early activation of the MET receptor in cells.
    3. MET exon 14 skipping mutations in non-small-cell lung cancer: real-world data from the Italian biomarker ATLAS database.
      Title: MET exon 14 skipping mutations in non-small-cell lung cancer: real-world data from the Italian biomarker ATLAS database.
    4. Differential Immune Checkpoint Protein Expression in HNSCC: The Role of HGF/MET Signaling.
      Title: Differential Immune Checkpoint Protein Expression in HNSCC: The Role of HGF/MET Signaling.
    5. PAX6 promotes neuroendocrine phenotypes of prostate cancer via enhancing MET/STAT5A-mediated chromatin accessibility.
      Title: PAX6 promotes neuroendocrine phenotypes of prostate cancer via enhancing MET/STAT5A-mediated chromatin accessibility.
    6. Deregulated immune cell recruitment orchestrated by c-MET impairs pulmonary inflammation and fibrosis.
      Title: Deregulated immune cell recruitment orchestrated by c-MET impairs pulmonary inflammation and fibrosis.
    7. Spatiotemporal regulation of the hepatocyte growth factor receptor MET activity by sorting nexins 1/2 in HCT116 colorectal cancer cells.
      Title: Spatiotemporal regulation of the hepatocyte growth factor receptor MET activity by sorting nexins 1/2 in HCT116 colorectal cancer cells.
    8. MET alterations in advanced non-small cell lung cancer.
      Title: MET alterations in advanced non-small cell lung cancer.
    9. MET overexpression correlated with prognosis of EGFR-mutant treatment-naive advanced lung adenocarcinoma: a real-world retrospective study.
      Title: MET overexpression correlated with prognosis of EGFR-mutant treatment‑naïve advanced lung adenocarcinoma: a real‑world retrospective study.
    10. Clinical, pathologic, and genomic characteristics of two pediatric glioneuronal tumors with a CLIP2::MET fusion.
      Title: Clinical, pathologic, and genomic characteristics of two pediatric glioneuronal tumors with a CLIP2::MET fusion.
    Submit: New GeneRIF Correction See all GeneRIFs (1253)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Arthrogryposis, distal, IIa 11
    MedGen: C5774205 OMIM: 620019 GeneReviews: Not available
    		Compare labs
    Autosomal recessive nonsyndromic hearing loss 97
    MedGen: C4084709 OMIM: 616705 GeneReviews: Not available
    		Compare labs
    Hepatocellular carcinoma
    MedGen: C2239176 OMIM: 114550 GeneReviews: Not available
    		Compare labs
    Osteofibrous dysplasia
    MedGen: C4085248 OMIM: 607278 GeneReviews: Not available
    		Compare labs
    Papillary renal cell carcinoma type 1
    MedGen: C1336839 OMIM: 605074 GeneReviews: Not available
    		Compare labs

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2012-09-06)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2012-09-06)

    ClinGen Genome Curation Page

    EBI GWAS Catalog

    Description
    Discovery and refinement of loci associated with lipid levels.
    EBI GWAS Catalog
    Genetic determinants of P wave duration and PR segment.
    EBI GWAS Catalog
    Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GPI-linked ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables boss receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables brain-derived neurotrophic factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables epidermal growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fibroblast growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hepatocyte growth factor receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables insulin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables insulin-like growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables macrophage colony-stimulating factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular function activator activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables placental growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables platelet-derived growth factor alpha-receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables platelet-derived growth factor beta-receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein tyrosine kinase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein tyrosine kinase collagen receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables semaphorin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables stem cell factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane-ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables vascular endothelial growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Kit signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in brain-derived neurotrophic factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in branching morphogenesis of an epithelial tube IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in collagen-activated tyrosine kinase receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endothelial cell morphogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ephrin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epidermal growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of skin barrier IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in excitatory postsynaptic potential ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hepatocyte growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in insulin-like growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in liver development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in macrophage colony-stimulating factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of Rho protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of autophagy NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of hydrogen peroxide-mediated programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of stress fiber assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of thrombin-activated receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pancreas development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in platelet-derived growth factor receptor-alpha signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in platelet-derived growth factor receptor-beta signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive chemotaxis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of endothelial cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of microtubule polymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in semaphorin-plexin signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in vascular endothelial growth factor receptor-1 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vascular endothelial growth factor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basal plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basal plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell surface HDA PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    hepatocyte growth factor receptor
    Names
    HGF receptor
    HGF/SF receptor
    SF receptor
    proto-oncogene c-Met
    scatter factor receptor
    tyrosine-protein kinase Met
    NP_000236.2
    NP_001120972.1
    NP_001311330.1
    NP_001311331.1
    XP_011514525.1
    XP_047276356.1
    XP_054214230.1
    XP_054214231.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008996.1 RefSeqGene

      Range
      5001..130982
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_662

    mRNA and Protein(s)

    1. NM_000245.4 → NP_000236.2  hepatocyte growth factor receptor isoform b preproprotein

      See identical proteins and their annotated locations for NP_000236.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AA278232, AC002080, BX648782, DB223186, X54559
      Consensus CDS
      CCDS43636.1
      UniProtKB/Swiss-Prot
      A1L467, B5A932, E7EQ94, O60366, P08581, Q12875, Q9UDX7, Q9UPL8
      Related
      ENSP00000380860.3, ENST00000397752.8
      Conserved Domains (7) summary
      cd11278
      Location:25 → 516
      Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
      smart00423
      Location:519 → 561
      PSI; domain found in Plexins, Semaphorins and Integrins
      smart00429
      Location:838 → 934
      IPT; ig-like, plexins, transcription factors
      cd01179
      Location:657 → 740
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:563 → 656
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01181
      Location:742 → 837
      IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd05058
      Location:1082 → 1343
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron

    2. NM_001127500.3 → NP_001120972.1  hepatocyte growth factor receptor isoform a preproprotein

      See identical proteins and their annotated locations for NP_001120972.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC002080, AC002543, BC130420, BX648782, DB223186, J02958
      Consensus CDS
      CCDS47689.1
      Related
      ENSP00000317272.6, ENST00000318493.11
      Conserved Domains (8) summary
      cd11278
      Location:25 → 516
      Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
      smart00423
      Location:519 → 561
      PSI; domain found in Plexins, Semaphorins and Integrins
      smart00429
      Location:856 → 952
      IPT; ig-like, plexins, transcription factors
      cd01179
      Location:657 → 740
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:563 → 656
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd05058
      Location:1100 → 1361
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
      pfam07714
      Location:1096 → 1355
      Pkinase_Tyr; Protein tyrosine kinase
      cl15674
      Location:742 → 855
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

    3. NM_001324401.3 → NP_001311330.1  hepatocyte growth factor receptor isoform c precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) encodes isoform c, which lacks a portion of the beta subunit.
      Source sequence(s)
      AC002080, DB223186, EU176015
      UniProtKB/TrEMBL
      B5A929, E6Y365, H7C174
      Related
      ENSP00000398776.2, ENST00000422097.2
      Conserved Domains (6) summary
      cd11278
      Location:25 → 516
      Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
      smart00423
      Location:519 → 561
      PSI; domain found in Plexins, Semaphorins and Integrins
      smart00429
      Location:838 → 918
      IPT; ig-like, plexins, transcription factors
      cd01179
      Location:657 → 740
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:563 → 656
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cl15674
      Location:742 → 837
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

    4. NM_001324402.2 → NP_001311331.1  hepatocyte growth factor receptor isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) encodes isoform d, which lacks a predicted signal peptide compared to isoforms a-c.
      Source sequence(s)
      AC002080, AC002543, AC004416, AI630755
      UniProtKB/TrEMBL
      B4DLF5
      Conserved Domains (8) summary
      smart00423
      Location:89 → 131
      PSI; domain found in Plexins, Semaphorins and Integrins
      smart00429
      Location:408 → 504
      IPT; ig-like, plexins, transcription factors
      cd01179
      Location:227 → 310
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:133 → 226
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd05058
      Location:652 → 913
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
      pfam07714
      Location:648 → 907
      Pkinase_Tyr; Protein tyrosine kinase
      cl15674
      Location:312 → 407
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
      cl15693
      Location:1 → 86
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      116672196..116798377
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011516223.2 → XP_011514525.1  hepatocyte growth factor receptor isoform X1

      Conserved Domains (8) summary
      cd11278
      Location:44 → 535
      Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
      smart00423
      Location:538 → 580
      PSI; domain found in Plexins, Semaphorins and Integrins
      smart00429
      Location:857 → 953
      IPT; ig-like, plexins, transcription factors
      cd01179
      Location:676 → 759
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:582 → 675
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01181
      Location:761 → 856
      IPT_plexin_repeat3; Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd05058
      Location:1101 → 1362
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
      pfam07714
      Location:1097 → 1356
      Pkinase_Tyr; Protein tyrosine kinase

    2. XM_047420400.1 → XP_047276356.1  hepatocyte growth factor receptor isoform X2

      UniProtKB/TrEMBL
      B5A931
      Related
      ENSP00000410980.2, ENST00000436117.3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      117987305..118113574
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358255.1 → XP_054214230.1  hepatocyte growth factor receptor isoform X1

    2. XM_054358256.1 → XP_054214231.1  hepatocyte growth factor receptor isoform X2

      UniProtKB/TrEMBL
      B5A931
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08581.4 GenPept UniProtKB/Swiss-Prot:P08581

    Gene LinkOut

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