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    MSI1 Msi1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852494, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MSI1
    Official Full Name
    Msi1p
    Primary source
    SGD:S000000399
    Locus tag
    YBR195C
    See related
    AllianceGenome:SGD:S000000399; FungiDB:YBR195C; VEuPathDB:YBR195C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CAC3
    Summary
    Contributes to histone binding activity. Involved in DNA replication-dependent chromatin assembly. Located in cytoplasm and nucleus. Part of CAF-1 complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MSI1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (610614..611882, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Med8p Neighboring gene Aim4p Neighboring gene glucose-6-phosphate isomerase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RIM2, MSI1 and PGI1 are located within an 8 kb segment of Saccharomyces cerevisiae chromosome II, which also contains the putative ribosomal gene L21 and a new putative essential gene with a leucine zipper motif. Démolis N, et al. Yeast, 1993 Jun. PMID 8346681
    2. Host genes that affect the target-site distribution of the yeast retrotransposon Ty1. Huang H, et al. Genetics, 1999 Apr. PMID 10101165, Free PMC Article
    3. MSI1, a negative regulator of the RAS-cAMP pathway in Saccharomyces cerevisiae. Ruggieri R, et al. Proc Natl Acad Sci U S A, 1989 Nov. PMID 2554329, Free PMC Article
    4. Ultraviolet radiation sensitivity and reduction of telomeric silencing in Saccharomyces cerevisiae cells lacking chromatin assembly factor-I. Kaufman PD, et al. Genes Dev, 1997 Feb 1. PMID 9030687
    5. The Cac2 subunit is essential for productive histone binding and nucleosome assembly in CAF-1. Mattiroli F, et al. Sci Rep, 2017 Apr 18. PMID 28418026, Free PMC Article

    See all (97) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rho5p is a target of Msi1p/Npr1p regulation and the regulatory circuit involving phosphorylation and ubiquitination.
      Title: Rho5p is involved in mediating the osmotic stress response in Saccharomyces cerevisiae, and its activity is regulated via Msi1p and Npr1p by phosphorylation and ubiquitination.
    2. Over-expression of YAK1 decreased the growth rate, but only in the presence of a functional MSI1 gene.
      Title: Mutual interdependence of MSI1 (CAC3) and YAK1 in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication-dependent chromatin assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of CAF-1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Rpd3L complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Rpd3L-Expanded complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Msi1p
    NP_009754.1
    • Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 affects multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of DNA damage checkpoint after DNA repair; chromatin dynamics during transcription; and repression of divergent noncoding transcription; Msi1p localizes to nucleus and cytoplasm and independently regulates the RAS/cAMP pathway via sequestration of Npr1p kinase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      610614..611882 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178543.1 → NP_009754.1  TPA: Msi1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009754.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQI9, P13712
      UniProtKB/TrEMBL
      B5VEE4, C7GKF4, D3UET9, G2W9J6, N1P6Y4
      Conserved Domains (3) summary
      sd00039
      Location:133 → 173
      7WD40; WD40 repeat [structural motif]
      pfam12265
      Location:21 → 88
      CAF1C_H4-bd; Histone-binding protein RBBP4 or subunit C of CAF1 complex
      cl29593
      Location:141 → 413
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13712.1

    Gene LinkOut

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