U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    GCC185 GRIP and coiled-coil domain containing 185 kDa [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41459, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    GCC185provided by FlyBase
    Official Full Name
    GRIP and coiled-coil domain containing 185 kDaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037979
    Locus tag
    Dmel_CG3532
    See related
    AllianceGenome:FB:FBgn0037979
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3532; dGCC185; Dmel\CG3532
    Summary
    Enables small GTPase binding activity. Predicted to be involved in protein localization to Golgi apparatus and retrograde transport, endosome to Golgi. Located in Golgi trans cisterna. Is expressed in adult head and spermatozoon. Orthologous to human GCC2 (GRIP and coiled-coil domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See GCC185 in Genome Data Viewer
    Location:
    87A5-87A5; 3-51 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12010772..12015059)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7836494..7840781)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Tachykinin Neighboring gene Ectoderm-expressed 3 Neighboring gene Kelch like family member 18 Neighboring gene DDB1 and CUL4 associated factor 12 Neighboring gene Spt3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Intimate functional interactions between TGS1 and the Smn complex revealed by an analysis of the Drosophila eye development. Maccallini P, et al. PLoS Genet, 2020 May. PMID 32453722, Free PMC Article
    2. bicoid RNA localization requires the trans-Golgi network. Cai X, et al. Hereditas, 2019. PMID 31528161, Free PMC Article
    3. The Arf family G protein Arl1 is required for secretory granule biogenesis in Drosophila. Torres IL, et al. J Cell Sci, 2014 May 15. PMID 24610947, Free PMC Article
    4. A stress assembly that confers cell viability by preserving ERES components during amino-acid starvation. Zacharogianni M, et al. Elife, 2014 Nov 11. PMID 25386913, Free PMC Article
    5. The golgin coiled-coil proteins of the Golgi apparatus. Munro S. Cold Spring Harb Perspect Biol, 2011 Jun 1. PMID 21436057, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi vesicle transport IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in protein localization to Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in retrograde transport, endosome to Golgi ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi trans cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    GRIP and coiled-coil domain containing 185 kDa
    Names
    CG3532-PB
    GCC185 ortholog
    GCC185-PB

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12010772..12015059
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104285.2 → NP_001097755.1  GRIP and coiled-coil domain containing 185 kDa [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097755.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q32KE8, Q9VGE4
      Conserved Domains (3) summary
      TIGR02168
      Location:35 → 813
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam01465
      Location:1058 → 1100
      GRIP; GRIP domain
      pfam07851
      Location:458 → 548
      TMPIT; TMPIT-like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VGE4 Q9VGE4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous