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    PDE1A phosphodiesterase 1A [ Homo sapiens (human) ]

    Gene ID: 5136, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PDE1Aprovided by HGNC
    Official Full Name
    phosphodiesterase 1Aprovided by HGNC
    Primary source
    HGNC:HGNC:8774
    See related
    Ensembl:ENSG00000115252 MIM:171890; AllianceGenome:HGNC:8774
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HCAM1; HCAM-1; HSPDE1A; CAM-PDE 1A; CAM-PDE-1A
    Summary
    Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1; MIM 114180)-dependent PDEs (CaM-PDEs) that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001 [PubMed 11342109]; Fidock et al., 2002 [PubMed 11747989]).[supplied by OMIM, Oct 2009]
    Expression
    Broad expression in thyroid (RPKM 7.4), brain (RPKM 6.5) and 18 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PDE1A in Genome Data Viewer
    Location:
    2q32.1
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (182140041..182716797, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (182629098..183205733, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (183004768..183388033, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 1C Neighboring gene uncharacterized LOC102724288 Neighboring gene RNA, 5S ribosomal pseudogene 113 Neighboring gene NANOG hESC enhancer GRCh37_chr2:182975215-182975716 Neighboring gene uncharacterized LOC124907915 Neighboring gene RNA, 7SL, cytoplasmic 267, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr2:183364154-183364284 Neighboring gene NANOG hESC enhancer GRCh37_chr2:183364377-183364935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16835 Neighboring gene NANOG hESC enhancer GRCh37_chr2:183456476-183457108 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:183490526-183491063 Neighboring gene uncharacterized LOC124907914 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:183516578-183517777 Neighboring gene uncharacterized LOC101929976 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16836 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16837 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:183581051-183581655 Neighboring gene DnaJ heat shock protein family (Hsp40) member C10 Neighboring gene MPRA-validated peak3967 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:183683314-183684194 Neighboring gene ribosomal protein L31 pseudogene 15 Neighboring gene uncharacterized LOC124907916 Neighboring gene frizzled related protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of a Common Variant for Coronary Heart Disease at PDE1A Contributes to Individualized Treatment Goals and Risk Stratification of Cardiovascular Complications in Chinese Patients With Type 2 Diabetes. Tam CHT, et al. Diabetes Care, 2023 Jun 1. PMID 37125963, Free PMC Article
    2. Isolation, expression and analysis of splice variants of a human Ca2+/calmodulin-stimulated phosphodiesterase (PDE1A). Snyder PB, et al. Cell Signal, 1999 Jul. PMID 10405764
    3. Human Ca2+/calmodulin-dependent phosphodiesterase PDE1A: novel splice variants, their specific expression, genomic organization, and chromosomal localization. Michibata H, et al. Biochim Biophys Acta, 2001 Jan 26. PMID 11342109
    4. PDE1A polymorphism contributes to the susceptibility of nephrolithiasis. Yang Z, et al. BMC Genomics, 2017 Dec 20. PMID 29262781, Free PMC Article
    5. Exploring pyrazolo[3,4-d]pyrimidine phosphodiesterase 1 (PDE1) inhibitors: a predictive approach combining comparative validated multiple molecular modelling techniques. Amin SA, et al. J Biomol Struct Dyn, 2018 Feb. PMID 28132591

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of a Common Variant for Coronary Heart Disease at PDE1A Contributes to Individualized Treatment Goals and Risk Stratification of Cardiovascular Complications in Chinese Patients With Type 2 Diabetes.
      Title: Identification of a Common Variant for Coronary Heart Disease at PDE1A Contributes to Individualized Treatment Goals and Risk Stratification of Cardiovascular Complications in Chinese Patients With Type 2 Diabetes.
    2. the p-substituted benzyl side chain at N2-position helps to enhance the PDE1 inhibitory profile. Depending on these observations, some new molecules are predicted that may possess better PDE1 inhibition
      Title: Exploring pyrazolo[3,4-d]pyrimidine phosphodiesterase 1 (PDE1) inhibitors: a predictive approach combining comparative validated multiple molecular modelling techniques.
    3. evidence that the rs182089527 mutation in PDE1A is involved in the development of nephrolithiasis and kidney cysts.
      Title: PDE1A polymorphism contributes to the susceptibility of nephrolithiasis.
    4. Report significant associations of PDE1A single nucleotide polymorphisms with diastolic blood pressure and carotid intima-media thickness.
      Title: Phosphodiesterase 1 regulation is a key mechanism in vascular aging.
    5. These results suggest that induction of PDE1A plays a critical role in cardiac fibroblast activation and cardiac fibrosis
      Title: Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart.
    6. PDE1A is suggested to be involved in epigenetic mechanisms by targeting the epigenetic integrator UHRF1.
      Title: Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis.
    7. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    9. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
      Title: Association of PDE11A global haplotype with major depression and antidepressant drug response.
    10. PDE1A is unlikely to play an important role in antidepressant outcome in this sample
      Title: Association study of phosphodiesterase genes in the Sequenced Treatment Alternatives to Relieve Depression sample.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide meta-analysis identifies variants associated with platinating agent susceptibility across populations
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat decreases the intracellular levels of cAMP and CREB ser-133 phosphorylation through a signal transduction pathway involving sequential activation of phosphatidylinositol 3-kinase, AKT, and cyclic nucleoside phosphodiesterases PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC26303

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cGMP catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of smooth muscle cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
    Names
    61 kDa Cam-PDE
    calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
    calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase
    phosphodiesterase 1A, calmodulin-dependent
    NP_001003683.1
    NP_001245241.1
    NP_001245242.1
    NP_001245243.1
    NP_001350800.1
    NP_001382187.1
    NP_001382188.1
    NP_001382189.1
    NP_001382190.1
    NP_001382191.1
    NP_001382192.1
    NP_001382193.1
    NP_001382194.1
    NP_001382195.1
    NP_001382196.1
    NP_001382197.1
    NP_001382198.1
    NP_005010.2
    XP_011509625.1
    XP_011509626.1
    XP_011509627.1
    XP_011509628.1
    XP_016859783.1
    XP_047300644.1
    XP_054198436.1
    XP_054198437.1
    XP_054198438.1
    XP_054198439.1
    XP_054198440.1
    XP_054198441.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003683.3 → NP_001003683.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2

      See identical proteins and their annotated locations for NP_001003683.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' and 3' UTRs, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC010888, AC011291, AC012500
      Consensus CDS
      CCDS33344.1
      UniProtKB/Swiss-Prot
      D3DPG5, P54750, Q86VZ0, Q9C0K8, Q9C0K9, Q9C0L0, Q9C0L1, Q9C0L2, Q9C0L3, Q9C0L4, Q9UFX3
      UniProtKB/TrEMBL
      B7Z226
      Related
      ENSP00000387037.1, ENST00000410103.2
      Conserved Domains (2) summary
      pfam00233
      Location:218 → 434
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:77 → 133
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    2. NM_001258312.3 → NP_001245241.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate start codon, compared to variant 1. The encoded isoform (3) is longer and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC010888, AC011291, AC012500
      UniProtKB/TrEMBL
      B7Z226
      Conserved Domains (2) summary
      pfam00233
      Location:222 → 438
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:81 → 137
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    3. NM_001258313.3 → NP_001245242.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 4

      See identical proteins and their annotated locations for NP_001245242.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' and 3' UTRs and uses an alternate start codon, compared to variant 1. The encoded isoform (4) is shorter and has distinct N- and C-termini, compared to isoform 1.
      Source sequence(s)
      AC010888, AC011291, AC012500
      Consensus CDS
      CCDS58741.1
      UniProtKB/TrEMBL
      B7Z226
      Related
      ENSP00000309269.9, ENST00000351439.10
      Conserved Domains (2) summary
      pfam00233
      Location:202 → 418
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:61 → 117
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    4. NM_001258314.3 → NP_001245243.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 5

      See identical proteins and their annotated locations for NP_001245243.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' and 3' UTRs and uses an alternate start codon, compared to variant 1. The encoded isoform (5) is shorter and has distinct N- and C-termini, compared to isoform 1.
      Source sequence(s)
      AC011291
      Consensus CDS
      CCDS74612.1
      UniProtKB/TrEMBL
      B7Z7A2
      Related
      ENSP00000350858.3, ENST00000358139.6
      Conserved Domains (2) summary
      pfam00233
      Location:184 → 400
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:43 → 99
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    5. NM_001363871.4 → NP_001350800.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and uses an alternate start codon, compared to variant 1. The encoded isoform (6) is shorter and has distinct N- terminus, compared to isoform 1.
      Source sequence(s)
      AC010888, AC011291, AC012500
      Consensus CDS
      CCDS86900.1
      UniProtKB/TrEMBL
      B7Z226
      Related
      ENSP00000386767.1, ENST00000409365.6
      Conserved Domains (2) summary
      pfam00233
      Location:202 → 418
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:61 → 117
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    6. NM_001395258.2 → NP_001382187.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC010888, AC011291, AC012500
      Consensus CDS
      CCDS2285.1
      UniProtKB/TrEMBL
      B7Z226
      Conserved Domains (2) summary
      pfam00233
      Location:218 → 434
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:77 → 133
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    7. NM_001395259.2 → NP_001382188.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC010888, AC011291, AC012500
      Consensus CDS
      CCDS2285.1
      UniProtKB/TrEMBL
      B7Z226
      Related
      ENSP00000512257.1, ENST00000482782.6
      Conserved Domains (2) summary
      pfam00233
      Location:218 → 434
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:77 → 133
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    8. NM_001395260.2 → NP_001382189.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC010888, AC011291, AC012500
      Consensus CDS
      CCDS2285.1
      UniProtKB/TrEMBL
      B7Z226
      Conserved Domains (2) summary
      pfam00233
      Location:218 → 434
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:77 → 133
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    9. NM_001395261.2 → NP_001382190.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC010888, AC011291, AC012500
      Consensus CDS
      CCDS2285.1
      UniProtKB/TrEMBL
      B7Z226
      Conserved Domains (2) summary
      pfam00233
      Location:218 → 434
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:77 → 133
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    10. NM_001395262.1 → NP_001382191.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC010888, AC011291, AC012500
      Consensus CDS
      CCDS33344.1
      UniProtKB/Swiss-Prot
      D3DPG5, P54750, Q86VZ0, Q9C0K8, Q9C0K9, Q9C0L0, Q9C0L1, Q9C0L2, Q9C0L3, Q9C0L4, Q9UFX3
      UniProtKB/TrEMBL
      B7Z226
      Related
      ENSP00000512258.1, ENST00000495511.2
      Conserved Domains (2) summary
      pfam00233
      Location:218 → 434
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:77 → 133
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    11. NM_001395263.1 → NP_001382192.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC010888, AC011291, AC012500
      Consensus CDS
      CCDS33344.1
      UniProtKB/Swiss-Prot
      D3DPG5, P54750, Q86VZ0, Q9C0K8, Q9C0K9, Q9C0L0, Q9C0L1, Q9C0L2, Q9C0L3, Q9C0L4, Q9UFX3
      UniProtKB/TrEMBL
      B7Z226
      Conserved Domains (2) summary
      pfam00233
      Location:218 → 434
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:77 → 133
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    12. NM_001395264.1 → NP_001382193.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC010888, AC011291, AC012500
      UniProtKB/TrEMBL
      B7Z226
      Conserved Domains (1) summary
      cd00077
      Location:202 → 373
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

    13. NM_001395265.2 → NP_001382194.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC010888, AC011291, AC012500
      UniProtKB/TrEMBL
      B7Z226, B7Z3A7
      Conserved Domains (2) summary
      pfam00233
      Location:114 → 330
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:14 → 29
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    14. NM_001395266.1 → NP_001382195.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC010888, AC011291, AC012500
      Conserved Domains (1) summary
      cd00077
      Location:218 → 389
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

    15. NM_001395267.1 → NP_001382196.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC010888, AC011291, AC012500
      Conserved Domains (1) summary
      cd00077
      Location:218 → 389
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

    16. NM_001395268.1 → NP_001382197.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC010888, AC011291, AC012500
      Conserved Domains (1) summary
      cd00077
      Location:202 → 373
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

    17. NM_001395269.1 → NP_001382198.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC011291
      Conserved Domains (1) summary
      cd00077
      Location:184 → 355
      HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

    18. NM_005019.7 → NP_005010.2  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform 1

      See identical proteins and their annotated locations for NP_005010.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC010888, AC011291, AC012500
      Consensus CDS
      CCDS2285.1
      UniProtKB/TrEMBL
      B7Z226
      Related
      ENSP00000410309.1, ENST00000435564.6
      Conserved Domains (2) summary
      pfam00233
      Location:218 → 434
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:77 → 133
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      182140041..182716797 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047444688.1 → XP_047300644.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X4

      UniProtKB/TrEMBL
      B7Z226

    2. XM_011511326.3 → XP_011509628.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X6

      UniProtKB/TrEMBL
      B7Z7A2
      Conserved Domains (2) summary
      pfam00233
      Location:184 → 400
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:43 → 99
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    3. XM_017004294.3 → XP_016859783.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X2

      UniProtKB/TrEMBL
      B7Z226

    4. XM_011511323.3 → XP_011509625.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1

      UniProtKB/TrEMBL
      B7Z226
      Conserved Domains (2) summary
      pfam00233
      Location:218 → 434
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:77 → 133
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    5. XM_011511325.4 → XP_011509627.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X5

      UniProtKB/TrEMBL
      B7Z226
      Conserved Domains (2) summary
      pfam00233
      Location:202 → 418
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:61 → 117
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    6. XM_011511324.4 → XP_011509626.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X3

      UniProtKB/TrEMBL
      B7Z226
      Conserved Domains (2) summary
      pfam00233
      Location:218 → 434
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:77 → 133
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    RNA

    1. XR_007076388.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      182629098..183205733 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054342464.1 → XP_054198439.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X4

      UniProtKB/TrEMBL
      B7Z226

    2. XM_054342466.1 → XP_054198441.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X6

      UniProtKB/TrEMBL
      B7Z7A2

    3. XM_054342462.1 → XP_054198437.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X2

      UniProtKB/TrEMBL
      B7Z226

    4. XM_054342461.1 → XP_054198436.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1

      UniProtKB/TrEMBL
      B7Z226

    5. XM_054342465.1 → XP_054198440.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X5

      UniProtKB/TrEMBL
      B7Z226

    6. XM_054342463.1 → XP_054198438.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X3

      UniProtKB/TrEMBL
      B7Z226

    RNA

    1. XR_008486392.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54750.2 GenPept UniProtKB/Swiss-Prot:P54750

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