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    KIF24 kinesin family member 24 [ Homo sapiens (human) ]

    Gene ID: 347240, updated on 10-Dec-2024

    Summary

    Official Symbol
    KIF24provided by HGNC
    Official Full Name
    kinesin family member 24provided by HGNC
    Primary source
    HGNC:HGNC:19916
    See related
    Ensembl:ENSG00000186638 MIM:613747; AllianceGenome:HGNC:19916
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C9orf48; bA571F15.4
    Summary
    This gene encodes a member of the kinesin superfamily of microtubule-based motor proteins which are involved in the intracellular transport of membranous organelles, protein complexes, and mRNAs. They also play critical roles in mitosis, morphogenesis, and signal transduction. The encoded protein contains an N-terminal sterile alpha motif (SAM) domain and an ATP-binding kinesin motor domain. It binds centriolar coiled coil protein 110 and centrosomal protein 97 and localizes to the mother centriole to regulate ciliogenesis by controlling microtubule polymerization. [provided by RefSeq, Mar 2017]
    Expression
    Broad expression in testis (RPKM 7.5), bone marrow (RPKM 4.2) and 25 other tissues See more
    Orthologs
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    Genomic context

    See KIF24 in Genome Data Viewer
    Location:
    9p13.3
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (34252380..34333671, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (34271317..34378395, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (34252378..34329266, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ubiquitin associated protein 1 Neighboring gene RNA, 5S ribosomal pseudogene 282 Neighboring gene MPRA-validated peak7226 silencer Neighboring gene ribosomal protein S8 pseudogene 9 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19843 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:34254397-34255596 Neighboring gene RNA, U2 small nuclear 50, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:34318623-34319288 Neighboring gene serpin family H member 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28308 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28307 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:34329280-34329787 Neighboring gene nudix hydrolase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34371826-34372326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34372327-34372827 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34375663-34376244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34376245-34376825 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19844 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34380811-34381416 Neighboring gene uncharacterized LOC124902144 Neighboring gene myogenesis regulating glycosidase Neighboring gene sperm microtubule inner protein 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ10933, FLJ43884, MGC125677, MGC125678

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding  
    enables identical protein binding PubMed 
    enables microtubule binding  
    enables microtubule motor activity  
    enables microtubule motor activity PubMed 
    enables protein binding PubMed 
    Component Evidence Code Pubs
    located_in centriole PubMed 
    located_in centrosome PubMed 
    located_in cytosol  
    is_active_in microtubule  
    part_of protein-containing complex PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053094.1 RefSeqGene

      Range
      8705..85593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_194313.4 → NP_919289.2  kinesin-like protein KIF24

      See identical proteins and their annotated locations for NP_919289.2

      Status: REVIEWED

      Source sequence(s)
      AK125180, AL353662, BC110502, BE856625, BF895212, BP871643, BU660279, DA906271, DT932659, DV080193, DV080194, HY066968
      Consensus CDS
      CCDS6551.2
      UniProtKB/Swiss-Prot
      Q2TB93, Q5T7B5, Q5T7B7, Q5T7B8, Q6ZU97, Q6ZUZ2, Q86XZ0, Q9NV43
      Related
      ENSP00000384433.1, ENST00000402558.7
      Conserved Domains (3) summary
      cd09541
      Location:3 → 62
      SAM_KIF24-like; SAM domain of KIF24-like subfamily
      cd01367
      Location:223 → 544
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group
      pfam00225
      Location:229 → 545
      Kinesin; Kinesin motor domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      34252380..34333671 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011517863.4 → XP_011516165.1  kinesin-like protein KIF24 isoform X2

      See identical proteins and their annotated locations for XP_011516165.1

      UniProtKB/Swiss-Prot
      Q2TB93, Q5T7B5, Q5T7B7, Q5T7B8, Q6ZU97, Q6ZUZ2, Q86XZ0, Q9NV43
      Conserved Domains (3) summary
      cd09541
      Location:3 → 62
      SAM_KIF24-like; SAM domain of KIF24-like subfamily
      cd01367
      Location:223 → 544
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group
      pfam00225
      Location:229 → 545
      Kinesin; Kinesin motor domain
    2. XM_047423343.1 → XP_047279299.1  kinesin-like protein KIF24 isoform X5

      Related
      ENSP00000368472.3, ENST00000379174.7
    3. XM_047423340.1 → XP_047279296.1  kinesin-like protein KIF24 isoform X3

    4. XM_047423342.1 → XP_047279298.1  kinesin-like protein KIF24 isoform X4

    5. XM_011517861.3 → XP_011516163.1  kinesin-like protein KIF24 isoform X1

      See identical proteins and their annotated locations for XP_011516163.1

      Conserved Domains (3) summary
      cd09541
      Location:34 → 93
      SAM_KIF24-like; SAM domain of KIF24-like subfamily
      cd01367
      Location:254 → 575
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group
      pfam00225
      Location:260 → 576
      Kinesin; Kinesin motor domain
    6. XM_017014697.3 → XP_016870186.1  kinesin-like protein KIF24 isoform X2

      UniProtKB/Swiss-Prot
      Q2TB93, Q5T7B5, Q5T7B7, Q5T7B8, Q6ZU97, Q6ZUZ2, Q86XZ0, Q9NV43
      Conserved Domains (3) summary
      cd09541
      Location:3 → 62
      SAM_KIF24-like; SAM domain of KIF24-like subfamily
      cd01367
      Location:223 → 544
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group
      pfam00225
      Location:229 → 545
      Kinesin; Kinesin motor domain
    7. XM_047423345.1 → XP_047279301.1  kinesin-like protein KIF24 isoform X7

    8. XM_047423344.1 → XP_047279300.1  kinesin-like protein KIF24 isoform X6

    9. XM_006716764.4 → XP_006716827.1  kinesin-like protein KIF24 isoform X8

      Conserved Domains (1) summary
      cl22853
      Location:47 → 86
      Motor_domain; Myosin and Kinesin motor domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      34271317..34378395 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362910.1 → XP_054218885.1  kinesin-like protein KIF24 isoform X2

    2. XM_054362914.1 → XP_054218889.1  kinesin-like protein KIF24 isoform X5

    3. XM_054362912.1 → XP_054218887.1  kinesin-like protein KIF24 isoform X3

    4. XM_054362913.1 → XP_054218888.1  kinesin-like protein KIF24 isoform X4

    5. XM_054362909.1 → XP_054218884.1  kinesin-like protein KIF24 isoform X1

    6. XM_054362911.1 → XP_054218886.1  kinesin-like protein KIF24 isoform X2

    7. XM_054362916.1 → XP_054218891.1  kinesin-like protein KIF24 isoform X7

    8. XM_054362915.1 → XP_054218890.1  kinesin-like protein KIF24 isoform X6

    9. XM_054362917.1 → XP_054218892.1  kinesin-like protein KIF24 isoform X8

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