ZNF268 zinc finger protein 268 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZNF268provided by HGNC
Official Full Name: zinc finger protein 268provided by HGNC
Primary source: HGNC:HGNC:13061
See related: Ensembl:ENSG00000090612 MIM:604753; AllianceGenome:HGNC:13061
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HZF3
Summary: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of non-canonical NF-kappaB signal transduction; and regulation of apoptotic process. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in thyroid (RPKM 5.9), kidney (RPKM 4.2) and 25 other tissues See more
Orthologs: all
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Genomic context

Location:: 12q24.33

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (133181495..133214832)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (133238807..133272083)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (133758081..133791418)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KRAB-Zinc Finger Protein ZNF268a Deficiency Attenuates the Virus-Induced Pro-Inflammatory Response by Preventing IKK Complex Assembly.
Title: KRAB-Zinc Finger Protein ZNF268a Deficiency Attenuates the Virus-Induced Pro-Inflammatory Response by Preventing IKK Complex Assembly.
The nuclear localization activity of KRAB domain is a conserved feature of ZNF268.
Title: Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1.
These results reveal a novel role of ZNF268b2 that contributes to cervical carcinogenesis in part through enhancing NF-kappaB signaling.
Title: The zinc finger protein ZNF268 is overexpressed in human cervical cancer and contributes to tumorigenesis via enhancing NF-κB signaling.
ZNF268 is a crucial downstream target and effector of GATA-1
Title: Knockdown of ZNF268, which is transcriptionally downregulated by GATA-1, promotes proliferation of K562 cells.
4 alternative transcripts of ZNF268 were detected in the human blood cells.
Title: [Cloning and characterization of two novel alternatively spliced transcripts of ZNF268].
aberrant alternative splicing of ZNF268 is a potential prognostic factor of and may contribute to human hematological malignancies.
Title: Aberrant alternative splicing of human zinc finger gene ZNF268 in human hematological malignancy.
results indicate that a spliced form of ZNF268 lacking the KRAB domain is located in the cytosol, where it seems to play a role in TNF-alpha-induced NF-kappaB activation by interacting with the IKK complex.
Title: A splice variant of the C(2)H(2)-type zinc finger protein, ZNF268s, regulates NF-kappaB activation by TNF-alpha.
Results demonstrate that the mammalian gene ZNF268 is regulated by hUpf1 via its promoter.
Title: The mammalian gene ZNF268 is regulated by hUpf1.
HTLV-1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive element-binding
Title: Human T-cell leukemia virus type 1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive element-binding protein/activating transcription factor pathway.
This protein has a conserved KRAB domain which localizes to the nucleus and has transcriptional repressor activity.
Title: The KRAB domain of zinc finger gene ZNF268: a potential transcriptional repressor.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D12S2117 (e-PCR)
- UniSTS:60775

D12S1186E (e-PCR)
- UniSTS:151457

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	NAS Non-traceable Author Statement more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity	NAS Non-traceable Author Statement more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to tumor necrosis factor	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of non-canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: zinc finger protein 268

Names: zinc finger protein 3; zinc finger protein HZF3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001165881.3 → NP_001159353.1 zinc finger protein 268 isoform a

See identical proteins and their annotated locations for NP_001159353.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode isoform a.

Source sequence(s)

AC226150, AW138703, BC110542, KF455750

Consensus CDS

CCDS45012.1

UniProtKB/Swiss-Prot

Q14587, Q8TDG8, Q96RH4, Q9BZJ9

Related

ENSP00000228289.5, ENST00000228289.9

Conserved Domains (6) summary

smart00349
Location:81 → 141

KRAB; krueppel associated box

COG5048
Location:497 → 910

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:558 → 578

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:556 → 578

zf-C2H2; Zinc finger, C2H2 type

pfam01352
Location:81 → 120

KRAB; KRAB box

pfam13465
Location:710 → 734

zf-H2C2_2; Zinc-finger double domain
NM_001165882.3 → NP_001159354.1 zinc finger protein 268 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) is shorter than isoform a.

Source sequence(s)

AC026786, AC226150, AW138703, BC110542, CN255799, KF455750

UniProtKB/TrEMBL

Q2TB61

Conserved Domains (6) summary

smart00349
Location:2 → 58

KRAB; krueppel associated box

COG5048
Location:414 → 827

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:475 → 495

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:473 → 495

zf-C2H2; Zinc finger, C2H2 type

pfam01352
Location:2 → 37

KRAB; KRAB box

pfam13465
Location:627 → 651

zf-H2C2_2; Zinc-finger double domain
NM_001165883.2 → NP_001159355.1 zinc finger protein 268 isoform d

See identical proteins and their annotated locations for NP_001159355.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks two exons in the coding region, which causes a frameshift compared to variant 1. The resulting isoform (d) has a shorter and distinct C-terminus compared to isoform a.

Source sequence(s)

AC026786, AC226150, AF317549, BC058548, KF455750

Consensus CDS

CCDS59240.1

UniProtKB/Swiss-Prot

Q14587

Related

ENSP00000467781.1, ENST00000539248.6
NM_001165884.3 → NP_001159356.2 zinc finger protein 268 isoform e

Status: VALIDATED

Description

Transcript Variant: This variant (6) lacks three alternate exons in the coding region, which causes a frameshift compared to variant 1. The resulting isoform (e) is shorter and has a distinct C-terminus compared to isoform a.

Source sequence(s)

AC226150, AF317549, AF432217, AW138703, KF455750

Consensus CDS

CCDS53854.1

UniProtKB/TrEMBL

F5H1T2

Related

ENSP00000438941.1, ENST00000536899.6
NM_001165885.2 → NP_001159357.1 zinc finger protein 268 isoform f

Status: VALIDATED

Description

Transcript Variant: This variant (7) lacks an alternate exon in the coding region, which causes a frameshift compared to variant 1. The resulting isoform (f) has a shorter and distinct C-terminus compared to isoform a.

Source sequence(s)

AC026786, AC226150, AF317549, DQ057356, KF455750

Consensus CDS

CCDS53851.1

UniProtKB/TrEMBL

F5H7L3

Related

ENSP00000442446.2, ENST00000541211.6
NM_001165886.2 → NP_001159358.1 zinc finger protein 268 isoform g

Status: VALIDATED

Description

Transcript Variant: This variant (8) lacks two alternate exons in the coding region, which causes a frameshift compared to variant 1. The resulting isoform (g) has a shorter and distinct C-terminus compared to isoform a.

Source sequence(s)

AC026786, AC226150, AF317549, DQ057357, KF455750

Consensus CDS

CCDS53853.1

UniProtKB/TrEMBL

F5H670

Related

ENSP00000437858.1, ENST00000542711.6
NM_001165887.2 → NP_001159359.1 zinc finger protein 268 isoform h

See identical proteins and their annotated locations for NP_001159359.1

Status: VALIDATED

Description

Transcript Variant: This variant (9) lacks an alternate in-frame exon and contains an alternate coding exon, which causes a frameshift compared to variant 1. The resulting isoform (h) lacks an internal segment and has a shorter and distinct C-terminus compared to isoform a.

Source sequence(s)

AC026786, AC226150, AF317549, DB079580, DQ057360, KF455750

Consensus CDS

CCDS53852.1

UniProtKB/TrEMBL

A0A087WV54, K7EQP6

Related

ENSP00000467922.1, ENST00000592241.5

Conserved Domains (1) summary

smart00349
Location:14 → 74

KRAB; krueppel associated box
NM_003415.3 → NP_003406.1 zinc finger protein 268 isoform a

See identical proteins and their annotated locations for NP_003406.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 2 both encode isoform a.

Source sequence(s)

AC226150, AF317549, KF455750

Consensus CDS

CCDS45012.1

UniProtKB/Swiss-Prot

Q14587, Q8TDG8, Q96RH4, Q9BZJ9

Related

ENSP00000444412.3, ENST00000536435.7

Conserved Domains (6) summary

smart00349
Location:81 → 141

KRAB; krueppel associated box

COG5048
Location:497 → 910

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:558 → 578

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:556 → 578

zf-C2H2; Zinc finger, C2H2 type

pfam01352
Location:81 → 120

KRAB; KRAB box

pfam13465
Location:710 → 734

zf-H2C2_2; Zinc-finger double domain
NM_152943.3 → NP_694422.2 zinc finger protein 268 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains an alternate coding exon, which causes a frameshift compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.

Source sequence(s)

AC226150, AF317549, AF385187, KF455750

Consensus CDS

CCDS59239.1

UniProtKB/TrEMBL

A0A075B6T9, E7EV44, H3BUM2

Related

ENSP00000439539.2, ENST00000541009.6

Conserved Domains (2) summary

smart00349
Location:81 → 141

KRAB; krueppel associated box

pfam01352
Location:81 → 120

KRAB; KRAB box