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    ARHGAP9 Rho GTPase activating protein 9 [ Homo sapiens (human) ]

    Gene ID: 64333, updated on 10-Dec-2024

    Summary

    Official Symbol
    ARHGAP9provided by HGNC
    Official Full Name
    Rho GTPase activating protein 9provided by HGNC
    Primary source
    HGNC:HGNC:14130
    See related
    Ensembl:ENSG00000123329 MIM:610576; AllianceGenome:HGNC:14130
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    10C; RGL1
    Summary
    This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity towards several Rho-family GTPases in vitro, converting them to an inactive GDP-bound state. It is implicated in regulating adhesion of hematopoietic cells to the extracellular matrix. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in spleen (RPKM 23.2), bone marrow (RPKM 22.4) and 14 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ARHGAP9 in Genome Data Viewer
    Location:
    12q13.3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (57472269..57488824, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (57440558..57457116, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (57866052..57882607, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902947 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6536 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6537 Neighboring gene inhibin subunit beta E Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4581 Neighboring gene GLI family zinc finger 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:57869684-57870573 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6538 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6539 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6540 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6541 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6542 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr12:57880828-57881775 and GRCh37_chr12:57881776-57882722 Neighboring gene methionyl-tRNA synthetase 1 Neighboring gene Sharpr-MPRA regulatory region 11633 Neighboring gene uncharacterized LOC124903093 Neighboring gene microRNA 6758

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC1295, FLJ16525

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytosol  
    located_in extracellular region  
    is_active_in plasma membrane  
    located_in secretory granule lumen  

    General protein information

    Preferred Names
    rho GTPase-activating protein 9
    Names
    rho-type GTPase-activating protein 9

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023205.2 RefSeqGene

      Range
      13949..21546
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001080156.3 → NP_001073625.1  rho GTPase-activating protein 9 isoform 3

      See identical proteins and their annotated locations for NP_001073625.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (3) has a shorter N-terminus compared to isoform 1. Variants 3 and 11 both encode the same isoform (3).
      Source sequence(s)
      AB030239, CB528354, DC390315
      Consensus CDS
      CCDS44928.1
      UniProtKB/Swiss-Prot
      Q9BRR9
      Related
      ENSP00000397950.2, ENST00000430041.6
      Conserved Domains (4) summary
      cd04403
      Location:337 → 541
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:140 → 252
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:139 → 251
      PH; PH domain
      pfam00397
      Location:35 → 61
      WW; WW domain
    2. NM_001080157.2 → NP_001073626.1  rho GTPase-activating protein 9 isoform 2

      See identical proteins and their annotated locations for NP_001073626.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AB030239, AK092763
      Consensus CDS
      CCDS44929.1
      UniProtKB/TrEMBL
      R4GN15
      Related
      ENSP00000394307.2, ENST00000424809.6
      Conserved Domains (4) summary
      cd13233
      Location:324 → 436
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:323 → 435
      PH; PH domain
      cl02570
      Location:521 → 639
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl17036
      Location:26 → 82
      SH3; Src Homology 3 domain superfamily
    3. NM_001319850.2 → NP_001306779.2  rho GTPase-activating protein 9 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, initiates translation at an alternate start codon and contains multiple additional 5' coding exons, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (4) has a longer N-terminus and is longer, compared to isoform 1.
      Source sequence(s)
      AC022506, BC006107
      Consensus CDS
      CCDS81705.2
      UniProtKB/Swiss-Prot
      B4DVI3, E9PDX9, Q8NAF3, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74, Q9BRR9
      UniProtKB/TrEMBL
      A0A2X0SF68
      Related
      ENSP00000377386.3, ENST00000393797.7
    4. NM_001319851.2 → NP_001306780.1  rho GTPase-activating protein 9 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion and contains an alternate segment in the 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. It initiates translation at a downstream start codon. The encoded isoform (5) has a shorter N-terminus and is shorter, compared to isoform 1.
      Source sequence(s)
      AC022506
      UniProtKB/TrEMBL
      B3KQ74
      Related
      ENST00000546200.5
      Conserved Domains (3) summary
      cd04403
      Location:210 → 414
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:1 → 106
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:8 → 105
      PH; PH domain
    5. NM_001319852.2 → NP_001306781.1  rho GTPase-activating protein 9 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, initiates translation at a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (6) has a shorter N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC022506
      UniProtKB/Swiss-Prot
      Q9BRR9
      Conserved Domains (4) summary
      cd04403
      Location:356 → 560
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:140 → 252
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:139 → 251
      PH; PH domain
      pfam00397
      Location:35 → 61
      WW; WW domain
    6. NM_001367422.1 → NP_001354351.1  rho GTPase-activating protein 9 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC022506
    7. NM_001367423.1 → NP_001354352.1  rho GTPase-activating protein 9 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC022506
    8. NM_001367424.1 → NP_001354353.1  rho GTPase-activating protein 9 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC022506
    9. NM_001367425.1 → NP_001354354.1  rho GTPase-activating protein 9 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC022506
    10. NM_001367426.1 → NP_001354355.1  rho GTPase-activating protein 9 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variant 3, encodes isoform 3.
      Source sequence(s)
      AC022506
      Consensus CDS
      CCDS44928.1
    11. NM_032496.4 → NP_115885.2  rho GTPase-activating protein 9 isoform 1

      See identical proteins and their annotated locations for NP_115885.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AB051853, DC408597
      Consensus CDS
      CCDS8941.2
      UniProtKB/TrEMBL
      A0A2X0SF68
      Related
      ENSP00000377380.3, ENST00000393791.8
      Conserved Domains (5) summary
      cd12143
      Location:26 → 82
      SH3_ARHGAP9; Src Homology 3 domain of Rho GTPase-activating protein 9 and similar proteins
      cd04403
      Location:521 → 725
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:324 → 436
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:323 → 435
      PH; PH domain
      pfam00397
      Location:219 → 245
      WW; WW domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      57472269..57488824 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047429331.1 → XP_047285287.1  rho GTPase-activating protein 9 isoform X3

      UniProtKB/Swiss-Prot
      B4DVI3, E9PDX9, Q8NAF3, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74, Q9BRR9
      UniProtKB/TrEMBL
      A0A2X0SF68
    2. XM_047429334.1 → XP_047285290.1  rho GTPase-activating protein 9 isoform X5

      UniProtKB/TrEMBL
      R4GN15
    3. XM_047429329.1 → XP_047285285.1  rho GTPase-activating protein 9 isoform X2

      UniProtKB/TrEMBL
      A0A2X0SF68
    4. XM_047429330.1 → XP_047285286.1  rho GTPase-activating protein 9 isoform X3

      UniProtKB/Swiss-Prot
      B4DVI3, E9PDX9, Q8NAF3, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74, Q9BRR9
      UniProtKB/TrEMBL
      A0A2X0SF68
    5. XM_011538659.3 → XP_011536961.1  rho GTPase-activating protein 9 isoform X4

      See identical proteins and their annotated locations for XP_011536961.1

      UniProtKB/TrEMBL
      R4GN15
      Related
      ENSP00000473445.2, ENST00000550288.6
      Conserved Domains (4) summary
      cd13233
      Location:324 → 436
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:323 → 435
      PH; PH domain
      cl02570
      Location:521 → 639
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl17036
      Location:26 → 82
      SH3; Src Homology 3 domain superfamily
    6. XM_011538656.3 → XP_011536958.1  rho GTPase-activating protein 9 isoform X1

      See identical proteins and their annotated locations for XP_011536958.1

      UniProtKB/TrEMBL
      A0A2X0SF68
      Conserved Domains (5) summary
      cd12143
      Location:26 → 82
      SH3_ARHGAP9; Src Homology 3 domain of Rho GTPase-activating protein 9 and similar proteins
      cd04403
      Location:521 → 725
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:324 → 436
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:323 → 435
      PH; PH domain
      pfam00397
      Location:219 → 245
      WW; WW domain
    7. XM_047429333.1 → XP_047285289.1  rho GTPase-activating protein 9 isoform X1

      UniProtKB/TrEMBL
      A0A2X0SF68
    8. XM_047429332.1 → XP_047285288.1  rho GTPase-activating protein 9 isoform X1

      UniProtKB/TrEMBL
      A0A2X0SF68
    9. XM_047429335.1 → XP_047285291.1  rho GTPase-activating protein 9 isoform X6

      UniProtKB/TrEMBL
      R4GN15
    10. XM_047429337.1 → XP_047285293.1  rho GTPase-activating protein 9 isoform X8

    11. XM_047429336.1 → XP_047285292.1  rho GTPase-activating protein 9 isoform X7

    12. XM_047429340.1 → XP_047285296.1  rho GTPase-activating protein 9 isoform X11

    13. XM_005269083.3 → XP_005269140.1  rho GTPase-activating protein 9 isoform X7

      See identical proteins and their annotated locations for XP_005269140.1

      UniProtKB/Swiss-Prot
      Q9BRR9
      Conserved Domains (4) summary
      cd04403
      Location:356 → 560
      RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
      cd13233
      Location:140 → 252
      PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
      pfam00169
      Location:139 → 251
      PH; PH domain
      pfam00397
      Location:35 → 61
      WW; WW domain
    14. XM_047429339.1 → XP_047285295.1  rho GTPase-activating protein 9 isoform X10

    15. XM_047429338.1 → XP_047285294.1  rho GTPase-activating protein 9 isoform X9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      57440558..57457116 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372872.1 → XP_054228847.1  rho GTPase-activating protein 9 isoform X5

      UniProtKB/TrEMBL
      R4GN15
    2. XM_054372868.1 → XP_054228843.1  rho GTPase-activating protein 9 isoform X3

      UniProtKB/TrEMBL
      A0A2X0SF68
    3. XM_054372871.1 → XP_054228846.1  rho GTPase-activating protein 9 isoform X4

      UniProtKB/TrEMBL
      R4GN15
    4. XM_054372867.1 → XP_054228842.1  rho GTPase-activating protein 9 isoform X1

      UniProtKB/TrEMBL
      A0A2X0SF68
    5. XM_054372870.1 → XP_054228845.1  rho GTPase-activating protein 9 isoform X1

      UniProtKB/TrEMBL
      A0A2X0SF68
    6. XM_054372869.1 → XP_054228844.1  rho GTPase-activating protein 9 isoform X1

      UniProtKB/TrEMBL
      A0A2X0SF68
    7. XM_054372873.1 → XP_054228848.1  rho GTPase-activating protein 9 isoform X6

      UniProtKB/TrEMBL
      R4GN15
    8. XM_054372875.1 → XP_054228850.1  rho GTPase-activating protein 9 isoform X7

    9. XM_054372876.1 → XP_054228851.1  rho GTPase-activating protein 9 isoform X8

    10. XM_054372879.1 → XP_054228854.1  rho GTPase-activating protein 9 isoform X11

    11. XM_054372874.1 → XP_054228849.1  rho GTPase-activating protein 9 isoform X7

    12. XM_054372877.1 → XP_054228852.1  rho GTPase-activating protein 9 isoform X12

    13. XM_054372878.1 → XP_054228853.1  rho GTPase-activating protein 9 isoform X13

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