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    NENF neudesin neurotrophic factor [ Homo sapiens (human) ]

    Gene ID: 29937, updated on 10-Dec-2024

    Summary

    Official Symbol
    NENFprovided by HGNC
    Official Full Name
    neudesin neurotrophic factorprovided by HGNC
    Primary source
    HGNC:HGNC:30384
    See related
    Ensembl:ENSG00000117691 MIM:611874; AllianceGenome:HGNC:30384
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CIR2; SPUF; SCIRP10
    Summary
    This gene encodes a neurotrophic factor that may play a role in neuron differentiation and development. A pseudogene of this gene is found on chromosome 12. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2009]
    Expression
    Ubiquitous expression in ovary (RPKM 25.5), prostate (RPKM 23.2) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See NENF in Genome Data Viewer
    Location:
    1q32.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (212432920..212446379)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (211677617..211691093)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (212606262..212619721)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene MPRA-validated peak686 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:212540447-212541032 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:212541033-212541616 Neighboring gene proton activated chloride channel 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:212558425-212558608 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1794 Neighboring gene uncharacterized LOC105372906 Neighboring gene CRISPRi-validated cis-regulatory element chr1.11595 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1795 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2504 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:212626055-212626874 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_3589 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_3606 Neighboring gene uncharacterized LOC124904506 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:212635334-212635848 Neighboring gene Sharpr-MPRA regulatory region 5085 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:212644924-212645424 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:212645425-212645925 Neighboring gene long intergenic non-protein coding RNA 2771

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables growth factor activity  
    enables metal ion binding  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in MAPK cascade  
    involved_in negative regulation of appetite  
    involved_in positive regulation of MAPK cascade  
    Component Evidence Code Pubs
    is_active_in endomembrane system  
    is_active_in endoplasmic reticulum  
    located_in endoplasmic reticulum PubMed 
    located_in extracellular space PubMed 
    is_active_in membrane  
    located_in mitochondrion PubMed 

    General protein information

    Preferred Names
    neudesin
    Names
    SCIRP10-related protein
    Spinal cord injury related protein 10
    cell growth-inhibiting protein 47
    cell immortalization-related protein 2
    neuron-derived neurotrophic factor
    secreted protein of unknown function

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013349.5NP_037481.1  neudesin precursor

      See identical proteins and their annotated locations for NP_037481.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AF173937, BC008823, DB574171
      Consensus CDS
      CCDS1505.1
      UniProtKB/Swiss-Prot
      A1KYQ8, Q53FZ6, Q5TM90, Q9UMX5
      Related
      ENSP00000355955.3, ENST00000366988.5
      Conserved Domains (1) summary
      pfam00173
      Location:48109
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

    RNA

    1. NR_026598.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC008823, DB502983, DB574171
      Related
      ENST00000479589.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      212432920..212446379
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      211677617..211691093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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