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    Pdha Pyruvate dehydrogenase E1 alpha subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31406, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pdhaprovided by FlyBase
    Official Full Name
    Pyruvate dehydrogenase E1 alpha subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028325
    Locus tag
    Dmel_CG7010
    See related
    AllianceGenome:FB:FBgn0028325
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG 7010; CG7010; Dmel\CG7010; E1-PDH; l (1) G0334; l(1)G0334; L(1)g0334; L(1)G0334; Pdh; PDH; PDH-E1; pdha; PDHA1; PDHalpha; Pdha[KK101856]; PDHE1
    Summary
    Predicted to enable pyruvate dehydrogenase (NAD+) activity and pyruvate dehydrogenase (acetyl-transferring) activity. Predicted to be involved in acetyl-CoA biosynthetic process from pyruvate. Located in mitochondrion. Is expressed in adult head; adult heart; and spermatozoon. Used to study disease of metabolism and retinal degeneration. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency and spermatogenic failure 70. Orthologous to human PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1) and PDHA2 (pyruvate dehydrogenase E1 subunit alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pdha in Genome Data Viewer
    Location:
    4C14-4C14; 1-8 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4702284..4705265)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (4596317..4599298)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Protein phosphatase 2C Neighboring gene cut up Neighboring gene uncharacterized protein Neighboring gene Proctolin receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Electron tomographic analysis reveals ultrastructural features of mitochondrial cristae architecture which reflect energetic state and aging. Jiang YF, et al. Sci Rep, 2017 Mar 30. PMID 28358017, Free PMC Article
    2. Regulation of Drosophila Intestinal Stem Cell Proliferation by Enterocyte Mitochondrial Pyruvate Metabolism. Wisidagama DR, et al. G3 (Bethesda), 2019 Nov 5. PMID 31488514, Free PMC Article
    3. Probiotic Lactobacillus spp. improves Drosophila memory by increasing lactate dehydrogenase levels in the brain mushroom body neurons. Ho SM, et al. Gut Microbes, 2024 Jan-Dec. PMID 38372783, Free PMC Article
    4. A comprehensive approach to determining BER capacities and their change with aging in Drosophila melanogaster mitochondria by oligonucleotide microarray. Garreau-Balandier I, et al. FEBS Lett, 2014 May 2. PMID 24642371
    5. Enhanced neuronal glucose transporter expression reveals metabolic choice in a HD Drosophila model. Besson MT, et al. PLoS One, 2015. PMID 25761110, Free PMC Article

    See all (79) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables pyruvate dehydrogenase (NAD+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables pyruvate dehydrogenase (acetyl-transferring) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyruvate dehydrogenase (acetyl-transferring) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to pyruvate dehydrogenase (acetyl-transferring) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetyl-CoA biosynthetic process from pyruvate IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in acetyl-CoA biosynthetic process from pyruvate IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in acetyl-CoA biosynthetic process from pyruvate ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    part_of pyruvate dehydrogenase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    pyruvate dehydrogenase E1 alpha subunit
    Names
    CG7010-PA
    CG7010-PB
    CG7010-PC
    CG7010-PD
    PDH complex
    Pdha-PA
    Pdha-PB
    Pdha-PC
    Pdha-PD
    l(1)G0334
    lethal (1) G0334
    pyruvate dehydrogenase
    NP_572181.4
    NP_726945.1
    NP_726946.1
    NP_726947.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      4702284..4705265
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167018.2 → NP_726946.1  pyruvate dehydrogenase E1 alpha subunit, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726946.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W4H5, Q9W4H6, Q9W4H7
      Related
      FBpp0070677
      Conserved Domains (1) summary
      cl01629
      Location:34 → 382
      TPP_enzymes; Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and ...

    2. NM_167017.3 → NP_726945.1  pyruvate dehydrogenase E1 alpha subunit, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726945.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KVX1
      Related
      FBpp0070679
      Conserved Domains (1) summary
      cl01629
      Location:78 → 426
      TPP_enzymes; Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and ...

    3. NM_167019.2 → NP_726947.1  pyruvate dehydrogenase E1 alpha subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726947.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YU05
      Related
      FBpp0070678
      Conserved Domains (1) summary
      cl01629
      Location:1 → 311
      TPP_enzymes; Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and ...

    4. NM_131953.5 → NP_572181.4  pyruvate dehydrogenase E1 alpha subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572181.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W4H5, Q9W4H6, Q9W4H7
      Related
      FBpp0070676
      Conserved Domains (1) summary
      cl01629
      Location:34 → 382
      TPP_enzymes; Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KVX1 Q7KVX1
    Q7YU05 Q7YU05
    Q9W4H6 Q9W4H6

    Gene LinkOut

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