TUP1 chromatin-silencing transcriptional regulator TUP1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TUP1
Official Full Name: chromatin-silencing transcriptional regulator TUP1
Primary source: SGD:S000000680
Locus tag: YCR084C
See related: AllianceGenome:SGD:S000000680; FungiDB:YCR084C; VEuPathDB:YCR084C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: AAR1; AER2; AMM1; CRT4; CYC9; FLK1; ROX4; SFL2; UMR7
Summary: Enables several functions, including histone deacetylase binding activity; mediator complex binding activity; and phosphatidylinositol-3,5-bisphosphate binding activity. Involved in several processes, including negative regulation of dipeptide transport; regulation of fatty acid biosynthetic process; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription repressor complex. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See TUP1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 1

Sequence:: Chromosome: III; NC_001135.5 (260311..262452, complement)

Chromosome III - NC_001135.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001135.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Systematic analysis of tup1 and cyc8 mutants reveals distinct roles for TUP1 and CYC8 and offers new insight into the regulation of gene transcription by the yeast Tup1-Cyc8 complex.
Title: Systematic analysis of tup1 and cyc8 mutants reveals distinct roles for TUP1 and CYC8 and offers new insight into the regulation of gene transcription by the yeast Tup1-Cyc8 complex.
Functional characterization and comparative analysis of gene repression-mediating domains interacting with yeast pleiotropic corepressors Sin3, Cyc8 and Tup1.
Title: Functional characterization and comparative analysis of gene repression-mediating domains interacting with yeast pleiotropic corepressors Sin3, Cyc8 and Tup1.
Tup1 is critical for transcriptional repression in Quiescence in S. cerevisiae.
Title: Tup1 is critical for transcriptional repression in Quiescence in S. cerevisiae.
Genetic analysis argues for a coactivator function for the Saccharomyces cerevisiae Tup1 corepressor.
Title: Genetic analysis argues for a coactivator function for the Saccharomyces cerevisiae Tup1 corepressor.
Transcriptional repressor Gal80 recruits corepressor complex Cyc8-Tup1 to structural genes of the Saccharomyces cerevisiae GAL regulon.
Title: Transcriptional repressor Gal80 recruits corepressor complex Cyc8-Tup1 to structural genes of the Saccharomyces cerevisiae GAL regulon.
Functional analysis of Cti6 core domain responsible for recruitment of epigenetic regulators Sin3, Cyc8 and Tup1.
Title: Functional analysis of Cti6 core domain responsible for recruitment of epigenetic regulators Sin3, Cyc8 and Tup1.
Glucose, Cyc8p and Tup1p regulate biofilm formation and dispersal in wild Saccharomyces cerevisiae.
Title: Glucose, Cyc8p and Tup1p regulate biofilm formation and dispersal in wild Saccharomyces cerevisiae.
Ash1 and Tup1 dependent repression of the Saccharomyces cerevisiae HO promoter requires activator-dependent nucleosome eviction.
Title: Ash1 and Tup1 dependent repression of the Saccharomyces cerevisiae HO promoter requires activator-dependent nucleosome eviction.
Study provides clear evidence of the functions of the Tup1p and Cyc8p regulators in biofilm colony formation. Cyc8p itself is a repressor of FLO11 gene expression and of the formation of the structured architecture of colony biofilms, whereas Tup1p counteracts Cyc8p, being a positive regulator of FLO11 expression and colony complexity.
Title: Cyc8p and Tup1p transcription regulators antagonistically regulate Flo11p expression and complexity of yeast colony biofilms.
Tup1 regulates GAL1 epigenetic transcriptional memory. Tup1 is necessary for incorporation of both H2A.Z and H3K4me2 at the GAL1 promoter.
Title: Epigenetic Transcriptional Memory of GAL Genes Depends on Growth in Glucose and the Tup1 Transcription Factor in Saccharomyces cerevisiae.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables histone binding	IDA Inferred from Direct Assay more info	PubMed
enables histone deacetylase binding	IDA Inferred from Direct Assay more info	PubMed
enables histone deacetylase binding	IPI Inferred from Physical Interaction more info	PubMed
enables mediator complex binding	IDA Inferred from Direct Assay more info	PubMed
enables mediator complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables phosphatidylinositol-3,5-bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ubiquitin-like ligase-substrate adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of dipeptide transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of fatty acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription repressor complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: chromatin-silencing transcriptional regulator TUP1

NP_010007.1

Transcriptional regulator; functions primarily as a transcriptional co-repressor with Cyc8p but can also function as a co-activator, recruiting SWI/SNF and SAGA complexes to promoters; target genes may be uniquely repressed by Tup1p or Cyc8p, subject to redundant repression, or in some cases de-repression of target genes in a tup1 mutant is dependent upon CYC8 and vice versa; establishes a repressive chromatin structure via histone H3/H4 interactions and stabilizing nucleosomes over promoters

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001135.5 Reference assembly

Range

260311..262452 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178790.1 → NP_010007.1 TPA: chromatin-silencing transcriptional regulator TUP1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010007.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VR85, P16649, P17995, P18323

UniProtKB/TrEMBL

B5VF12, C7GUW4

Conserved Domains (3) summary

cd00200
Location:343 → 706

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:347 → 383

7WD40; WD40 repeat [structural motif]

pfam08581
Location:11 → 88

Tup_N; Tup N-terminal