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    STU1 Stu1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852246, updated on 9-Dec-2024

    Summary

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    Official Symbol
    STU1
    Official Full Name
    Stu1p
    Primary source
    SGD:S000000130
    Locus tag
    YBL034C
    See related
    AllianceGenome:SGD:S000000130; FungiDB:YBL034C; VEuPathDB:YBL034C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables beta-tubulin binding activity; kinetochore binding activity; and microtubule binding activity. Involved in attachment of spindle microtubules to kinetochore and mitotic spindle assembly. Located in kinetochore; mitotic spindle midzone; and polar microtubule. Orthologous to human CLASP2 (cytoplasmic linker associated protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See STU1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (153848..158389, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene DNA-directed DNA polymerase alpha subunit POL12 Neighboring gene GTP cyclohydrolase II Neighboring gene Hek2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. STU1, a suppressor of a beta-tubulin mutation, encodes a novel and essential component of the yeast mitotic spindle. Pasqualone D, et al. J Cell Biol, 1994 Dec. PMID 7806575, Free PMC Article
    2. Molecular mechanisms facilitating the initial kinetochore encounter with spindle microtubules. Vasileva V, et al. J Cell Biol, 2017 Jun 5. PMID 28446512, Free PMC Article
    3. Unattached kinetochores drive their own capturing by sequestering a CLASP. Kolenda C, et al. Nat Commun, 2018 Feb 28. PMID 29491436, Free PMC Article
    4. An isolated CLASP TOG domain suppresses microtubule catastrophe and promotes rescue. Majumdar S, et al. Mol Biol Cell, 2018 Jun 1. PMID 29851564, Free PMC Article
    5. Stu1p is physically associated with beta-tubulin and is required for structural integrity of the mitotic spindle. Yin H, et al. Mol Biol Cell, 2002 Jun. PMID 12058056, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Slk19 enhances cross-linking of microtubules by Ase1 and Stu1.
      Title: Slk19 enhances cross-linking of microtubules by Ase1 and Stu1.
    2. The withdrawal of Stu1, a CLASP essential for spindle integrity, from microtubules and attached kinetochores disrupts the organization of the spindle and thus allows the enhanced formation of dynamic random microtubules that span the nucleus and are ideal to capture unattached kinetochores.
      Title: Unattached kinetochores drive their own capturing by sequestering a CLASP.
    3. We show that only TOGL2 of Saccharomyces cerevisiae CLASP Stu1 binds to tubulin and is required for polymerization of spindle microtubules (MTs) in vivo.
      Title: A TOGL domain specifically targets yeast CLASP to kinetochores to stabilize kinetochore microtubules.
    4. sequestering of Stu1 by detached kinetochores serves as a checkpoint that keeps spindle poles in close proximity until all kinetochores are captured
      Title: Stu1 inversely regulates kinetochore capture and spindle stability.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables beta-tubulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-tubulin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables kinetochore binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in astral microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in attachment of spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitotic spindle midzone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in polar microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Stu1p
    NP_009519.1
    • Microtubule plus-end-tracking non-motor protein; binds to MTs, stabilizing interpolar MT plus ends, facilitating polymerization of spindle MTs and producing an outward force on spindle poles; required for structural integrity of the mitotic spindle; binds detached kinetochores (KTs) and promotes capture; relocalizes to MTs and stabilizes the spindle once captured KTs reach a spindle pole; localizes to the spindle, spindles poles, and detached KTs; CLASP family member homologous to human CLASP1/2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      153848..158389 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178274.1 → NP_009519.1  TPA: Stu1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009519.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPW5, P38198
      UniProtKB/TrEMBL
      G2W8X4, N1P8Z8
      Conserved Domains (1) summary
      pfam12348
      Location:318 → 560
      CLASP_N; CLASP N terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38198.1

    Gene LinkOut

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