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    RRN5 Rrn5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850832, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RRN5
    Official Full Name
    Rrn5p
    Primary source
    SGD:S000004131
    Locus tag
    YLR141W
    See related
    AllianceGenome:SGD:S000004131; FungiDB:YLR141W; VEuPathDB:YLR141W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA polymerase I general transcription initiation factor activity. Involved in chromatin organization and nucleolar large rRNA transcription by RNA polymerase I. Located in nucleolus. Part of RNA polymerase I upstream activating factor complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RRN5 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (423683..424774)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Nha1p Neighboring gene Sls1p Neighboring gene proline dehydrogenase Neighboring gene tRNA-Asp

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DNA protein-interactions at the Saccharomyces cerevisiae 35 S rRNA promoter and in its surrounding region. Vogelauer M, et al. J Mol Biol, 1998 Jan 16. PMID 9466903
    2. RNA polymerase switch in transcription of yeast rDNA: role of transcription factor UAF (upstream activation factor) in silencing rDNA transcription by RNA polymerase II. Vu L, et al. Proc Natl Acad Sci U S A, 1999 Apr 13. PMID 10200272, Free PMC Article
    3. Multiprotein transcription factor UAF interacts with the upstream element of the yeast RNA polymerase I promoter and forms a stable preinitiation complex. Keys DA, et al. Genes Dev, 1996 Apr 1. PMID 8846924
    4. Histones are required for transcription of yeast rRNA genes by RNA polymerase I. Tongaonkar P, et al. Proc Natl Acad Sci U S A, 2005 Jul 19. PMID 16002464, Free PMC Article
    5. Histones H3 and H4 are components of upstream activation factor required for the high-level transcription of yeast rDNA by RNA polymerase I. Keener J, et al. Proc Natl Acad Sci U S A, 1997 Dec 9. PMID 9391047, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA polymerase I general transcription initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables rDNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleolar large rRNA transcription by RNA polymerase I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleolar large rRNA transcription by RNA polymerase I IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleolar large rRNA transcription by RNA polymerase I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase I promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase I upstream activating factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase I upstream activating factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RNA polymerase I upstream activating factor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rrn5p
    NP_013242.1
    • Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      423683..424774
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182028.1 → NP_013242.1  TPA: Rrn5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013242.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYD5, Q02983, Q12061
      UniProtKB/TrEMBL
      C8ZDB0, N1P6N4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02983.1

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