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    SEC20 Sec20p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852109, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SEC20
    Official Full Name
    Sec20p
    Primary source
    SGD:S000002906
    Locus tag
    YDR498C
    See related
    AllianceGenome:SGD:S000002906; FungiDB:YDR498C; VEuPathDB:YDR498C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable SNAP receptor activity. Involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in endoplasmic reticulum and membrane. Part of SNARE complex. Orthologous to human BNIP1 (BCL2 interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SEC20 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1445843..1446994, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Puf6p Neighboring gene myo-inositol transporter ITR1 Neighboring gene Lcd1p Neighboring gene ribosomal 60S subunit protein L37B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Saccharomyces cerevisiae SEC20 gene encodes a membrane glycoprotein which is sorted by the HDEL retrieval system. Sweet DJ, et al. EMBO J, 1992 Feb. PMID 1537327, Free PMC Article
    2. The yeast SEC20 gene is required for N- and O-glycosylation in the Golgi. Evidence that impaired glycosylation does not correlate with the secretory defect. Schleip I, et al. J Biol Chem, 2001 Aug 3. PMID 11477110
    3. The TIP1 gene of Saccharomyces cerevisiae encodes an 80 kDa cytoplasmic protein that interacts with the cytoplasmic domain of Sec20p. Sweet DJ, et al. EMBO J, 1993 Jul. PMID 8334998, Free PMC Article
    4. SNARE-mediated retrograde traffic from the Golgi complex to the endoplasmic reticulum. Lewis MJ, et al. Cell, 1996 Apr 19. PMID 8612273
    5. Structural characterization of Tip20p and Dsl1p, subunits of the Dsl1p vesicle tethering complex. Tripathi A, et al. Nat Struct Mol Biol, 2009 Feb. PMID 19151722, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SEC20, SEC39, and DSL1 are essential secretory genes involved in the early stages of peroxisome assembly.
      Title: Endoplasmic reticulum-associated secretory proteins Sec20p, Sec39p, and Dsl1p are involved in peroxisome biogenesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables SNAP receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SNAP receptor activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SNARE complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sec20p
    NP_010786.3
    • Membrane glycoprotein v-SNARE; involved in retrograde transport from the Golgi to the endoplasmic reticulum (ER); required for N- and O-glycosylation in the Golgi but not in the ER and for efficient nuclear fusion during mating; mediates Sey1p-independent homotypic ER fusion; interacts with the Dsl1p complex through Tip20p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1445843..1446994 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180806.3 → NP_010786.3  TPA: Sec20p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010786.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTC0, P28791
      UniProtKB/TrEMBL
      G2WBM6, N1P7G2
      Conserved Domains (1) summary
      pfam03908
      Location:204 → 295
      Sec20
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28791.1

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