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    LST7 Lst7p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852948, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LST7
    Official Full Name
    Lst7p
    Primary source
    SGD:S000003289
    Locus tag
    YGR057C
    See related
    AllianceGenome:SGD:S000003289; FungiDB:YGR057C; VEuPathDB:YGR057C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to GTPase activator activity. Involved in cellular response to amino acid stimulus and positive regulation of TORC1 signaling. Located in vacuolar membrane. Part of FNIP-folliculin RagC/D GAP. Human ortholog(s) of this gene implicated in Birt-Hogg-Dube syndrome; colorectal cancer; primary spontaneous pneumothorax; and renal cell carcinoma. Orthologous to human FLCN (folliculin). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LST7 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (604773..605501, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Mup1p Neighboring gene RSC subunit protein RSC1 Neighboring gene Pef1p Neighboring gene septin SPR3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast genes involved in regulating cysteine uptake affect production of hydrogen sulfide from cysteine during fermentation. Huang CW, et al. FEMS Yeast Res, 2017 Aug 1. PMID 28810701
    2. Amino Acids Stimulate TORC1 through Lst4-Lst7, a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr2. Péli-Gulli MP, et al. Cell Rep, 2015 Oct 6. PMID 26387955
    3. Feedback Inhibition of the Rag GTPase GAP Complex Lst4-Lst7 Safeguards TORC1 from Hyperactivation by Amino Acid Signals. Péli-Gulli MP, et al. Cell Rep, 2017 Jul 11. PMID 28700931
    4. LST1 is a SEC24 homologue used for selective export of the plasma membrane ATPase from the endoplasmic reticulum. Roberg KJ, et al. J Cell Biol, 1999 May 17. PMID 10330397, Free PMC Article
    5. Amino acid homeostatic control by TORC1 in Saccharomyces cerevisiae under high hydrostatic pressure. Uemura S, et al. J Cell Sci, 2020 Sep 9. PMID 32801125

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Amino acids stimulate TORC1 through Lst4-Lst7, a GTPase-activating protein complex for the Rag family GTPase Gtr2.
      Title: Amino Acids Stimulate TORC1 through Lst4-Lst7, a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to amino acid stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of FNIP-folliculin RagC/D GAP IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in vacuolar membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Lst7p
    NP_011571.4
    • Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p; stimulates the GTPase activity of Rag family GTPase Gtr2p, within the context of the Gtr1p-Gtr2p heterodimer, after amino acid stimulation; required for activation of TORC1 in response to amino acid stimulation; recruited to the vacuolar membrane during amino acid starvation and released from the membrane by TORC1; required for the transport of amino acid permease Gap1p from the Golgi to the cell surface

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      604773..605501 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181186.3 → NP_011571.4  TPA: Lst7p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011571.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUJ2, P53237, Q45U29
      UniProtKB/TrEMBL
      A6ZV42, B3LIG6, C7GXP0, C8Z8V1, N1P3V8
      Conserved Domains (1) summary
      pfam11704
      Location:70 → 235
      Folliculin; Vesicle coat protein involved in Golgi to plasma membrane transport
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53237.2

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