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    VTH1 signal sequence-binding protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854634, updated on 9-Dec-2024

    Summary

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    Official Symbol
    VTH1
    Official Full Name
    signal sequence-binding protein
    Primary source
    SGD:S000001435
    Locus tag
    YIL173W
    See related
    AllianceGenome:SGD:S000001435; FungiDB:YIL173W; VEuPathDB:YIL173W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables signal sequence binding activity. Involved in Golgi to vacuole transport. Located in endosome and fungal-type vacuole. Human ortholog(s) of this gene implicated in Alzheimer's disease and abdominal aortic aneurysm. Orthologous to several human genes including SORT1 (sortilin 1) and SORL1 (sortilin related receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See VTH1 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (11492..16141)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene seripauperin PAU14 Neighboring gene pseudo Neighboring gene pseudo Neighboring gene oligo-1,6-glucosidase IMA3 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Vps10p cycles between the late-Golgi and prevacuolar compartments in its function as the sorting receptor for multiple yeast vacuolar hydrolases. Cooper AA, et al. J Cell Biol, 1996 May. PMID 8636229, Free PMC Article
    2. Multiple pathways for vacuolar sorting of yeast proteinase A. Westphal V, et al. J Biol Chem, 1996 May 17. PMID 8662642
    3. Analysis of an inactivated Lg-FLO1 gene present in bottom-fermenting yeast. Sato M, et al. J Biosci Bioeng, 2002. PMID 16233220
    4. An overexpression screen in Saccharomyces cerevisiae identifies novel genes that affect endocytic protein trafficking. Arlt H, et al. Traffic, 2011 Nov. PMID 21777356
    5. Transfer of the Septin Ring to Cytokinetic Remnants in ER Stress Directs Age-Sensitive Cell-Cycle Re-entry. Chao JT, et al. Dev Cell, 2019 Oct 21. PMID 31564614, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signal sequence binding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to endosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to vacuole transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to vacuole transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein targeting to vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuolar transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome HDA PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    signal sequence-binding protein
    NP_012095.1
    • Putative membrane glycoprotein; has strong similarity to Vth2p and Pep1p/Vps10p; may be involved in vacuolar protein sorting

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      11492..16141
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179519.1 → NP_012095.1  TPA: signal sequence-binding protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012095.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C8ZAZ9, D6VVB8, P40438
      Conserved Domains (1) summary
      smart00602
      Location:728 → 1355
      VPS10; VPS10 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40438.1

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