Mpc1 mitochondrial pyruvate carrier 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mpc1provided by MGI
Official Full Name: mitochondrial pyruvate carrier 1provided by MGI
Primary source: MGI:MGI:1915240
See related: Ensembl:ENSMUSG00000023861 AllianceGenome:MGI:1915240
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Brp44l; 0610006G08Rik; 3830411I18Rik
Summary: Enables pyruvate transmembrane transporter activity. Involved in acetyl-CoA biosynthetic process from pyruvate. Acts upstream of or within cellular response to leukemia inhibitory factor and mitochondrial pyruvate transmembrane transport. Located in mitochondrion. Is active in mitochondrial inner membrane. Is expressed in several structures, including adrenal gland; hemolymphoid system; nervous system; olfactory epithelium; and retina. Human ortholog(s) of this gene implicated in mitochondrial pyruvate carrier deficiency. Orthologous to human MPC1 (mitochondrial pyruvate carrier 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in heart adult (RPKM 57.7), subcutaneous fat pad adult (RPKM 57.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A1; 17 4.92 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (8502590..8516499)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (8283787..8297667)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mitochondrial pyruvate carrier 1 regulates fatty acid synthase lactylation and mediates treatment of nonalcoholic fatty liver disease.
Title: Mitochondrial pyruvate carrier 1 regulates fatty acid synthase lactylation and mediates treatment of nonalcoholic fatty liver disease.
Inactivation of mitochondrial pyruvate carrier promotes NLRP3 inflammasome activation and gout development via metabolic reprogramming.
Title: Inactivation of mitochondrial pyruvate carrier promotes NLRP3 inflammasome activation and gout development via metabolic reprogramming.
Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier.
Title: Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier.
Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development.
Title: Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development.
Retina-specific deletion of MPC1 results in progressive retinal degeneration and decline of visual function in both rod and cone photoreceptors.
Title: Loss of MPC1 reprograms retinal metabolism to impair visual function.
the MPC1 knockout blocks mitochondrial pyruvate uptake and OXPHOS, which results in metabolic reprogramming towards aerobic Warburg glycolysis with reduced ATP production capability.
Title: Mitochondrial pyruvate carrier function determines cell stemness and metabolic reprogramming in cancer cells.
Heterozygous MPC1 KO weakens fertility and influences the metabolism of glucose and fatty acid and bodyweight in mice.
Title: Establishment of mitochondrial pyruvate carrier 1 (MPC1) gene knockout mice with preliminary gene function analyses.
This study suggests that inhibition of MPC1 activity can boost fatty acid oxidation to provide sufficient energy to the body.
Title: Fatty acid oxidation alleviates the energy deficiency caused by the loss of MPC1 in MPC1(+/-) mice.
Our study indicates that MPC1 and MPC2 expressions are of prognostic values in PCAs and that positive expression of MPC1 or MPC2 is a predictor of favorable outcome.
Title: MPC1 and MPC2 expressions are associated with favorable clinical outcomes in prostate cancer.
Results show that Mpc1 is required for mammalian embryonic development and efficient pyruvate metabolism.
Title: Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Brp44l (e-PCR), detects polymorphism
- UniSTS:226033

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables pyruvate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to pyruvate transmembrane transporter activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within acetyl-CoA biosynthetic process from pyruvate	IC Inferred by Curator more info	PubMed
acts_upstream_of_or_within acetyl-CoA biosynthetic process from pyruvate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in acetyl-CoA biosynthetic process from pyruvate	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in mitochondrial pyruvate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitochondrial pyruvate transmembrane transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitochondrial pyruvate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial pyruvate transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	HDA more info	PubMed
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial pyruvate carrier 1

Names: apoptosis-regulating basic protein; brain protein 44-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001364918.1 → NP_001351847.1 mitochondrial pyruvate carrier 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC164431, AK002266, BY160030, BY256631

Consensus CDS

CCDS88985.1

UniProtKB/TrEMBL

D3YWY6

Related

ENSMUSP00000118386.2, ENSMUST00000124023.8

Conserved Domains (1) summary

pfam03650
Location:2 → 81

MPC; Uncharacterized protein family (UPF0041)
NM_001364919.1 → NP_001351848.1 mitochondrial pyruvate carrier 1 isoform 3

Status: VALIDATED

Source sequence(s)

AC164431

Consensus CDS

CCDS88984.1

UniProtKB/TrEMBL

E9Q0V4, Q9D6B6

Related

ENSMUSP00000119901.2, ENSMUST00000142594.8

Conserved Domains (1) summary

pfam03650
Location:82 → 163

MPC; Uncharacterized protein family (UPF0041)
NM_018819.5 → NP_061289.1 mitochondrial pyruvate carrier 1 isoform 1

See identical proteins and their annotated locations for NP_061289.1

Status: VALIDATED

Source sequence(s)

AC164431, AK013391, BY160030

Consensus CDS

CCDS49944.1

UniProtKB/Swiss-Prot

P63030, Q9D6C0, Q9JLG5

UniProtKB/TrEMBL

Q3TCV4, Q3UX28

Related

ENSMUSP00000119443.2, ENSMUST00000155364.8

Conserved Domains (1) summary

pfam03650
Location:24 → 105

MPC; Uncharacterized protein family (UPF0041)

RNA

NR_157360.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC164431

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

8502590..8516499

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030249914.2 → XP_030105774.1 mitochondrial pyruvate carrier 1 isoform X2

Conserved Domains (1) summary

pfam03650
Location:1 → 62

MPC; Uncharacterized protein family (UPF0041)
XM_011246219.4 → XP_011244521.1 mitochondrial pyruvate carrier 1 isoform X1

See identical proteins and their annotated locations for XP_011244521.1

UniProtKB/TrEMBL

D3Z5S0

Related

ENSMUSP00000116307.2, ENSMUST00000130559.2

Conserved Domains (1) summary

pfam03650
Location:3 → 82

MPC; Uncharacterized protein family (UPF0041)