Arsi arylsulfatase i [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arsiprovided by MGI
Official Full Name: arylsulfatase iprovided by MGI
Primary source: MGI:MGI:2670959
See related: Ensembl:ENSMUSG00000036412 AllianceGenome:MGI:2670959
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable metal ion binding activity and sulfuric ester hydrolase activity. Predicted to be located in endoplasmic reticulum and extracellular region. Is expressed in several structures, including cartilage condensation; foregut; limb; notochord; and sensory organ. Orthologous to human ARSI (arylsulfatase family member I). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in thymus adult (RPKM 20.1), limb E14.5 (RPKM 13.2) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 E1; 18 34.41 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (61045063..61051633)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (60911991..60919506)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sulfuric ester hydrolase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: arylsulfatase I

Names: ASI

NP_001033588.1

EC 3.1.6.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001038499.2 → NP_001033588.1 arylsulfatase I precursor

See identical proteins and their annotated locations for NP_001033588.1

Status: VALIDATED

Source sequence(s)

AC124431, AC139759

Consensus CDS

CCDS29275.1

UniProtKB/Swiss-Prot

Q32KI9

Related

ENSMUSP00000043966.6, ENSMUST00000040359.6

Conserved Domains (2) summary

COG3119
Location:47 → 492

AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]

cd16029
Location:47 → 478

4-S; N-acetylgalactosamine 4-sulfatase, also called arylsulftase B