Tagln2 transgelin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tagln2provided by MGI
Official Full Name: transgelin 2provided by MGI
Primary source: MGI:MGI:1312985
See related: Ensembl:ENSMUSG00000026547 AllianceGenome:MGI:1312985
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sm22B; Sm22a; SM22beta; 2700094C18Rik
Summary: Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization and epithelial cell differentiation. Predicted to be active in actin cytoskeleton. Is expressed in several structures, including autopod; cardiovascular system; gut; hemolymphoid system gland; and telencephalon ventricular layer. Orthologous to human TAGLN2 (transgelin 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in stomach adult (RPKM 455.3), lung adult (RPKM 276.3) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H3; 1 79.89 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (172327813..172334942)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (172500246..172507375)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MicroRNA133b alleviates doxorubicininduced cardiomyocyte apoptosis and cardiac fibrosis by targeting PTBP1 and TAGLN2.
Title: MicroRNA‑133b alleviates doxorubicin‑induced cardiomyocyte apoptosis and cardiac fibrosis by targeting PTBP1 and TAGLN2.
Cell-permeable transgelin-2 as a potent therapeutic for dendritic cell-based cancer immunotherapy.
Title: Cell-permeable transgelin-2 as a potent therapeutic for dendritic cell-based cancer immunotherapy.
Current findings highlight the contribution of cytoskeletal TAGLN2 to the obese phenotype in a gender-dependent manner
Title: Cytoskeletal transgelin 2 contributes to gender-dependent adipose tissue expandability and immune function.
An unidentified role of TAGLN2 in regulation of trophoblast invasion.
Title: Transgelin 2 is required for embryo implantation by promoting actin polymerization.
dual functional nature of TAGLN2-G-actin polymerization and Arp2/3 complex inhibition-may account for the mechanisms of filopodia development at the edge of Arp2/3-rich lamellipodia in various cell types
Title: TAGLN2 polymerizes G-actin in a low ionic state but blocks Arp2/3-nucleated actin branching in physiological conditions.
These results revealed a novel function of TAGLN2 as a molecular armament required for host defense.
Title: An Essential Role for TAGLN2 in Phagocytosis of Lipopolysaccharide-activated Macrophages.
transgelin-2 may also be involved in IS stability in B-cells, thereby influencing T-cell function
Title: Transgelin-2 in B-Cells Controls T-Cell Activation by Stabilizing T Cell - B Cell Conjugates.
All these results indicated a crucial role for Tagln2 in TECs for tumor development and metastasis.
Title: Identification and verification of transgelin-2 as a potential biomarker of tumor-derived lung-cancer endothelial cells by comparative proteomics.
A novel function of TAGLN2 in enhancing T cell responses by controlling actin stability at the immunological synapse.
Title: TAGLN2 regulates T cell activation by stabilizing the actin cytoskeleton at the immunological synapse.
The results indicate that miR-133b may play important roles in the growth and maturation of oocytes by regulating its potential target, TAGLN2, at both transcription and translation levels.
Title: MiR-133b regulates the expression of the Actin protein TAGLN2 during oocyte growth and maturation: a potential target for infertility therapy.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tagln2 (e-PCR), detects polymorphism
- UniSTS:144540

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transgelin-2

Names: SM22-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178598.2 → NP_848713.1 transgelin-2

See identical proteins and their annotated locations for NP_848713.1

Status: VALIDATED

Source sequence(s)

AK151576

Consensus CDS

CCDS35784.1

UniProtKB/Swiss-Prot

Q3TIB8, Q6A0C6, Q78ZX2, Q91VU2, Q9WVA4

Related

ENSMUSP00000106861.2, ENSMUST00000111230.8

Conserved Domains (3) summary

COG5199
Location:14 → 188

SCP1; Calponin [Cytoskeleton]

cd00014
Location:25 → 136

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

pfam00402
Location:174 → 197

Calponin; Calponin family repeat