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    Iqcf1 IQ motif containing F1 [ Mus musculus (house mouse) ]

    Gene ID: 74267, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Iqcf1provided by MGI
    Official Full Name
    IQ motif containing F1provided by MGI
    Primary source
    MGI:MGI:1921517
    See related
    Ensembl:ENSMUSG00000066383 AllianceGenome:MGI:1921517
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700055J15Rik
    Summary
    Enables calmodulin binding activity. Involved in positive regulation of acrosome reaction and positive regulation of flagellated sperm motility involved in capacitation. Located in acrosomal vesicle. Orthologous to human IQCF1 (IQ motif containing F1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 187.3) See more
    Orthologs
    human all
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    Genomic context

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    See Iqcf1 in Genome Data Viewer
    Location:
    9 F1; 9 57.65 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (106377166..106379449)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (106499967..106502250)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E716 Neighboring gene poly (ADP-ribose) polymerase family, member 3 Neighboring gene ribosomal RNA processing 9, U3 small nucleolar RNA binding protein Neighboring gene STARR-seq mESC enhancer starr_25152 Neighboring gene IQ motif containing F5 Neighboring gene STARR-positive B cell enhancer mm9_chr9:106434062-106434362 Neighboring gene IQ motif containing F2 Neighboring gene IQ motif containing F3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel acrosomal protein, IQCF1, involved in sperm capacitation and the acrosome reaction. Fang P, et al. Andrology, 2015 Mar. PMID 25380116
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of acrosome reaction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of acrosome reaction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of flagellated sperm motility involved in capacitation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in acrosomal vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    IQ domain-containing protein F1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146701.1 → NP_001140173.1  IQ domain-containing protein F1 isoform 2

      See identical proteins and their annotated locations for NP_001140173.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
      Source sequence(s)
      AC151729
      Consensus CDS
      CCDS52911.1
      UniProtKB/Swiss-Prot
      Q9D9K8
      Related
      ENSMUSP00000126039.2, ENSMUST00000164965.3

    2. NM_028843.1 → NP_083119.1  IQ domain-containing protein F1 isoform 1

      See identical proteins and their annotated locations for NP_083119.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC151729, AK006797
      Consensus CDS
      CCDS52910.1
      UniProtKB/Swiss-Prot
      Q810M2, Q9D9K8
      Related
      ENSMUSP00000082195.6, ENSMUST00000085114.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      106377166..106379449
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D9K8.1 GenPept UniProtKB/Swiss-Prot:Q9D9K8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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