ORC2 origin recognition complex subunit 2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ORC2
Official Full Name: origin recognition complex subunit 2
Primary source: SGD:S000000264
Locus tag: YBR060C
See related: AllianceGenome:SGD:S000000264; FungiDB:YBR060C; VEuPathDB:YBR060C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: RRR1; SIR5
Summary: Enables DNA replication origin binding activity and chromatin binding activity. Involved in DNA-templated DNA replication and constitutive heterochromatin formation. Part of DNA replication preinitiation complex; nuclear origin of replication recognition complex; and nuclear pre-replicative complex. Orthologous to human ORC2 (origin recognition complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ORC2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (360652..362514, complement)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Evolution of DNA replication origin specification and gene silencing mechanisms.
Title: Evolution of DNA replication origin specification and gene silencing mechanisms.
In this study, yeast two-hybrid analysis was used to examine the interaction between Cdt1p and every ORC subunit; potent interaction with Orc6p, and weaker interaction with Orc2p and Orc5p was observed.
Title: Interaction between ORC and Cdt1p of Saccharomyces cerevisiae.
Orc2 mediates sister-chromatid interaction on a pathway that is additive with Cohesin-mediated pairing.
Title: The origin recognition complex functions in sister-chromatid cohesion in Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA replication origin binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA replication origin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in DNA replication initiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in DNA replication initiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pre-replicative complex assembly involved in nuclear cell cycle DNA replication	IDA Inferred from Direct Assay more info	PubMed
involved_in silent mating-type cassette heterochromatin formation	IDA Inferred from Direct Assay more info	PubMed
involved_in subtelomeric heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of DNA replication preinitiation complex	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
part_of nuclear origin of replication recognition complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear origin of replication recognition complex	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear origin of replication recognition complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of nuclear pre-replicative complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of origin recognition complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: origin recognition complex subunit 2

NP_009616.1

Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1p and with trimethylated histone H3; phosphorylated by Cdc28p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

360652..362514 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178408.1 → NP_009616.1 TPA: origin recognition complex subunit 2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009616.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VQ60, P32833

UniProtKB/TrEMBL

G2W966, N1P8B0

Conserved Domains (1) summary

COG5575
Location:24 → 620

ORC2; Origin recognition complex, subunit 2 [DNA replication, recombination, and repair]