Nrxn1 neurexin I [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nrxn1provided by MGI
Official Full Name: neurexin Iprovided by MGI
Primary source: MGI:MGI:1096391
See related: Ensembl:ENSMUSG00000024109 AllianceGenome:MGI:1096391
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0578; 1700062G21Rik; 9330127H16Rik; A230068P09Rik
Summary: This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are synaptic transmembrane receptors that bind endogenous ligands that include neuroligins, dystroglycan, and neurexophilins. Neurexin complexes are required for efficient neurotransmission and are involved in synaptogenesis. In vertebrates, alternate promoter usage results in multiple isoform classes, of which the alpha and beta classes are the best characterized. In humans, allelic variants in this gene are associated with Pitt-Hopkins-like syndrome-2, while deletions have been associated with autism and schizophrenia. Mouse knockouts display decreased spontaneous and evoked vesicle release resulting in impaired synaptic transmission. In addition, knockout mice show altered social approach, reduced social investigation, reduced locomotor activity, and in males, increased aggression. Alternative splicing and promoter usage result in multiple transcript variants. [provided by RefSeq, Nov 2016]
Expression: Biased expression in cortex adult (RPKM 21.2), frontal lobe adult (RPKM 17.5) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 E5; 17 59.73 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (90341072..91400587, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (90033644..91093159, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neurexin-3 subsynaptic densities are spatially distinct from Neurexin-1 and essential for excitatory synapse nanoscale organization in the hippocampus.
Title: Neurexin-3 subsynaptic densities are spatially distinct from Neurexin-1 and essential for excitatory synapse nanoscale organization in the hippocampus.
Alternative splicing and heparan sulfation converge on neurexin-1 to control glutamatergic transmission and autism-related behaviors.
Title: Alternative splicing and heparan sulfation converge on neurexin-1 to control glutamatergic transmission and autism-related behaviors.
Allelic contribution of Nrxn1alpha to autism-relevant behavioral phenotypes in mice.
Title: Allelic contribution of Nrxn1α to autism-relevant behavioral phenotypes in mice.
Neurexin1 differentially regulates synaptic efficacy within striatal circuits.
Title: Neurexin1⍺ differentially regulates synaptic efficacy within striatal circuits.
Ketamine Restores Thalamic-Prefrontal Cortex Functional Connectivity in a Mouse Model of Neurodevelopmental Disorder-Associated 2p16.3 Deletion.
Title: Ketamine Restores Thalamic-Prefrontal Cortex Functional Connectivity in a Mouse Model of Neurodevelopmental Disorder-Associated 2p16.3 Deletion.
Dopaminergic neurons establish a distinctive axonal arbor with a majority of non-synaptic terminals.
Title: Dopaminergic neurons establish a distinctive axonal arbor with a majority of non-synaptic terminals.
Alternative splicing of neurexins 1-3 is modulated by neuroinflammation in the prefrontal cortex of a murine model of multiple sclerosis.
Title: Alternative splicing of neurexins 1-3 is modulated by neuroinflammation in the prefrontal cortex of a murine model of multiple sclerosis.
Disruption of Nrxn1alpha within excitatory forebrain circuits drives value-based dysfunction.
Title: Disruption of Nrxn1α within excitatory forebrain circuits drives value-based dysfunction.
Specific Neuroligin3-alphaNeurexin1 signaling regulates GABAergic synaptic function in mouse hippocampus.
Title: Specific Neuroligin3-αNeurexin1 signaling regulates GABAergic synaptic function in mouse hippocampus.
Assessing the developmental trajectory of mouse models of neurodevelopmental disorders: Social and communication deficits in mice with Neurexin 1alpha deletion.
Title: Assessing the developmental trajectory of mouse models of neurodevelopmental disorders: Social and communication deficits in mice with Neurexin 1α deletion.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Targeted (11) 1 citation
Transposon induced (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D17Mit221 (e-PCR), detects polymorphism
- UniSTS:128037

D17Mit244 (e-PCR), detects polymorphism
- UniSTS:128056

D17Mit96 (e-PCR), detects polymorphism
- UniSTS:128118

D17Mit96.2 (e-PCR), detects polymorphism
- UniSTS:128119

NoName (e-PCR)
- UniSTS:225195

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acetylcholine receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium channel regulator activity	IGI Inferred from Genetic Interaction more info	PubMed
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium-dependent protein binding	IDA Inferred from Direct Assay more info	PubMed
enables cell adhesion molecule binding	IPI Inferred from Physical Interaction more info	PubMed
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables neuroligin family protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables neuroligin family protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables type 1 fibroblast growth factor receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of AMPA selective glutamate receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in NMDA glutamate receptor clustering	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of NMDA selective glutamate receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of adult behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adult behavior	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	NAS Non-traceable Author Statement more info	PubMed
involved_in cell-cell adhesion involved in synapse maturation	NAS Non-traceable Author Statement more info	PubMed
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in cerebellar granule cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within chemical synaptic transmission	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of protein localization	IDA Inferred from Direct Assay more info	PubMed
involved_in filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gamma-aminobutyric acid receptor clustering	IDA Inferred from Direct Assay more info	PubMed
involved_in gephyrin clustering involved in postsynaptic density assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in guanylate kinase-associated protein clustering	IDA Inferred from Direct Assay more info	PubMed
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IDA Inferred from Direct Assay more info	PubMed
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in learning	ISO Inferred from Sequence Orthology more info
involved_in maintenance of synapse structure	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of filopodium assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in neuroligin clustering involved in postsynaptic membrane assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of neuromuscular process controlling balance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron cell-cell adhesion	NAS Non-traceable Author Statement more info	PubMed
involved_in neuron maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuron projection morphogenesis	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within neurotransmitter secretion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neurotransmitter secretion	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory postsynaptic potential	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuromuscular synaptic transmission	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of neuron projection development	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase A signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase C activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of synapse assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of synapse maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synaptic transmission, GABAergic	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of synaptic transmission, glutamatergic	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic transmission, glutamatergic	NAS Non-traceable Author Statement more info	PubMed
involved_in postsynaptic density protein 95 clustering	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic membrane assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in prepulse inhibition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in presynapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in presynapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in presynapse assembly	ISO Inferred from Sequence Orthology more info
involved_in presynaptic membrane assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to synapse	IDA Inferred from Direct Assay more info	PubMed
involved_in protein-containing complex assembly involved in synapse maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor localization to synapse	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of regulation of grooming behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic density assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic density assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic specialization assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic specialization assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of presynapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of presynapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic vesicle cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	ISO Inferred from Sequence Orthology more info
involved_in social behavior	ISO Inferred from Sequence Orthology more info
involved_in synapse assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of synapse assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within synapse assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse assembly	NAS Non-traceable Author Statement more info	PubMed
involved_in synapse maturation	NAS Non-traceable Author Statement more info	PubMed
involved_in synaptic membrane adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic membrane adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic vesicle clustering	IDA Inferred from Direct Assay more info	PubMed
involved_in trans-synaptic signaling, modulating synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in trans-synaptic signaling, modulating synaptic transmission	IEP Inferred from Expression Pattern more info	PubMed
involved_in trans-synaptic signaling, modulating synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vocal learning	ISO Inferred from Sequence Orthology more info
involved_in vocalization behavior	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in GABA-ergic synapse	NAS Non-traceable Author Statement more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in axonal growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in endocytic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in excitatory synapse	IC Inferred by Curator more info
located_in excitatory synapse	NAS Non-traceable Author Statement more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in glutamatergic synapse	NAS Non-traceable Author Statement more info	PubMed
located_in inhibitory synapse	IC Inferred by Curator more info	PubMed
located_in inhibitory synapse	NAS Non-traceable Author Statement more info	PubMed
located_in neuromuscular junction	NAS Non-traceable Author Statement more info	PubMed
located_in neuron to neuron synapse	NAS Non-traceable Author Statement more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IC Inferred by Curator more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone membrane	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IMP Inferred from Mutant Phenotype more info	PubMed
part_of protein complex involved in cell-cell adhesion	EXP Inferred from Experiment more info	PubMed
part_of protein complex involved in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IPI Inferred from Physical Interaction more info	PubMed
located_in slit diaphragm	ISO Inferred from Sequence Orthology more info
part_of trans-synaptic protein complex	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: neurexin-1

Names: alpha-latrotoxin receptor (calcium-dependent); neurexin 1 NRXN1+7a; neurexin 1 NRXN1-7

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001346957.1 → NP_001333886.1 neurexin-1 isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AC101872, AC151286, AC167814, AC171209, CT025708, CT486002

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

Conserved Domains (6) summary

smart00294
Location:1405 → 1423

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:495 → 644

LamG; Laminin G domain

cd00054
Location:672 → 705

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1385 → 1424

Syndecan; Syndecan domain

pfam02210
Location:916 → 1041

Laminin_G_2; Laminin G domain
NM_001346958.2 → NP_001333887.1 neurexin-1 isoform 4 precursor

Status: REVIEWED

Source sequence(s)

AC101872, AC170901, CT025708, CT486002

Consensus CDS

CCDS84342.1

UniProtKB/TrEMBL

A0A0H2UH29

Related

ENSMUSP00000134402.3, ENSMUST00000172466.8
NM_001346959.2 → NP_001333888.1 neurexin-1 isoform 5 precursor

Status: REVIEWED

Source sequence(s)

AC101872, AC170901, CT025708, CT486002

Consensus CDS

CCDS84341.1

UniProtKB/Swiss-Prot

P0DI97

Related

ENSMUSP00000133724.3, ENSMUST00000174337.8
NM_001346960.2 → NP_001333889.1 neurexin-1 isoform 6

Status: REVIEWED

Source sequence(s)

AC101872, AC170901, CT025708, CT486002

Consensus CDS

CCDS84340.1

UniProtKB/TrEMBL

E0CZA5

Related

ENSMUSP00000125561.3, ENSMUST00000159778.8
NM_001346961.2 → NP_001333890.1 neurexin-1 isoform 7

Status: REVIEWED

Source sequence(s)

AC101872, AC170901, CT025708, CT486002
NM_001346962.2 → NP_001333891.1 neurexin-1 isoform 8

Status: REVIEWED

Source sequence(s)

CT486002

Consensus CDS

CCDS84339.1

UniProtKB/Swiss-Prot

Q9CS84

Related

ENSMUSP00000142815.2, ENSMUST00000197268.5

Conserved Domains (2) summary

smart00294
Location:84 → 102

4.1m; putative band 4.1 homologues' binding motif

pfam01034
Location:64 → 99

Syndecan; Syndecan domain
NM_001347419.2 → NP_001334348.1 neurexin-1 isoform 9

Status: REVIEWED

Source sequence(s)

CT486002

Consensus CDS

CCDS84338.1

UniProtKB/TrEMBL

G3UWQ9

Related

ENSMUSP00000133389.3, ENSMUST00000173917.8

Conserved Domains (2) summary

smart00294
Location:87 → 105

4.1m; putative band 4.1 homologues' binding motif

pfam01034
Location:67 → 102

Syndecan; Syndecan domain
NM_001403319.1 → NP_001390248.1 neurexin-1 isoform 18 precursor

Status: REVIEWED

Source sequence(s)

AC101872, AC151286, AC167814, AC171209, CT025708, CT486002
NM_001403320.1 → NP_001390249.1 neurexin-1 isoform 20 precursor

Status: REVIEWED

Source sequence(s)

AC101872, AC151286, AC167814, AC171209, CT025708, CT486002
NM_001403321.1 → NP_001390250.1 neurexin-1 isoform 19 precursor

Status: REVIEWED

Source sequence(s)

AC101872, AC151286, AC167814, AC171209, CT025708, CT486002
NM_001403322.1 → NP_001390251.1 neurexin-1 isoform 18 precursor

Status: REVIEWED

Source sequence(s)

AC101872, AC151286, AC167814, AC171209, CT025708, CT486002
NM_001403323.1 → NP_001390252.1 neurexin-1 isoform 17 precursor

Status: REVIEWED

Source sequence(s)

AC101872, AC151286, AC167814, AC171209, CT025708, CT486002
NM_001403324.1 → NP_001390253.1 neurexin-1 isoform 16 precursor

Status: REVIEWED

Source sequence(s)

AC101872, AC151286, AC167814, AC171209, CT025708, CT486002
NM_001403325.1 → NP_001390254.1 neurexin-1 isoform 15 precursor

Status: REVIEWED

Source sequence(s)

AC101872, AC151286, AC167814, AC171209, CT025708, CT486002
NM_001403326.1 → NP_001390255.1 neurexin-1 isoform 14 precursor

Status: REVIEWED

Source sequence(s)

AC101872, AC151286, AC167814, AC171209, CT025708, CT486002
NM_001403327.1 → NP_001390256.1 neurexin-1 isoform 13 precursor

Status: REVIEWED

Source sequence(s)

AC101872, AC151286, AC167814, AC171209, CT025708, CT486002
NM_001403328.1 → NP_001390257.1 neurexin-1 isoform 12 precursor

Status: REVIEWED

Source sequence(s)

AC101872, AC151286, AC167814, AC171209, CT025708, CT486002
NM_001403329.1 → NP_001390258.1 neurexin-1 isoform 12 precursor

Status: REVIEWED

Source sequence(s)

AC101872, AC151286, AC167814, AC171209, CT025708, CT486002
NM_001403330.1 → NP_001390259.1 neurexin-1 isoform 11 precursor

Status: REVIEWED

Source sequence(s)

AC101872, AC151286, AC167814, AC171209, CT025708, CT486002
NM_001403331.1 → NP_001390260.1 neurexin-1 isoform 11 precursor

Status: REVIEWED

Source sequence(s)

AC101872, AC151286, AC167814, AC171209, CT025708, CT486002
NM_001403332.1 → NP_001390261.1 neurexin-1 isoform 10 precursor

Status: REVIEWED

Source sequence(s)

AC101872, AC151286, AC167814, AC171209, CT025708, CT486002
NM_020252.4 → NP_064648.3 neurexin-1 isoform 1 precursor

Status: REVIEWED

Source sequence(s)

AC101872, AC151286, AC167814, AC171209, CT025708, CT486002

Consensus CDS

CCDS57113.1

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

Related

ENSMUSP00000125407.4, ENSMUST00000160844.10

Conserved Domains (6) summary

smart00294
Location:1452 → 1470

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:503 → 652

LamG; Laminin G domain

cd00054
Location:680 → 713

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1432 → 1467

Syndecan; Syndecan domain

pfam02210
Location:933 → 1061

Laminin_G_2; Laminin G domain
NM_177284.3 → NP_796258.2 neurexin-1 isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AC101872, AC151286, AC167814, AC171209, CT025708, CT486002

Consensus CDS

CCDS57112.1

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

UniProtKB/TrEMBL

E0CY11

Related

ENSMUSP00000124561.3, ENSMUST00000160800.9

Conserved Domains (6) summary

smart00294
Location:1440 → 1458

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:491 → 640

LamG; Laminin G domain

cd00054
Location:668 → 701

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1420 → 1455

Syndecan; Syndecan domain

pfam02210
Location:921 → 1049

Laminin_G_2; Laminin G domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

90341072..91400587 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017317307.2 → XP_017172796.1 neurexin-1 isoform X19

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

Conserved Domains (6) summary

smart00294
Location:1433 → 1451

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:475 → 624

LamG; Laminin G domain

cd00054
Location:652 → 685

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1413 → 1448

Syndecan; Syndecan domain

pfam02210
Location:905 → 1033

Laminin_G_2; Laminin G domain
XM_036160374.1 → XP_036016267.1 neurexin-1 isoform X15

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

Conserved Domains (6) summary

smart00294
Location:1441 → 1459

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:483 → 632

LamG; Laminin G domain

cd00054
Location:660 → 693

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1421 → 1456

Syndecan; Syndecan domain

pfam02210
Location:913 → 1041

Laminin_G_2; Laminin G domain
XM_036160367.1 → XP_036016260.1 neurexin-1 isoform X3

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

Conserved Domains (6) summary

smart00294
Location:1457 → 1475

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:499 → 648

LamG; Laminin G domain

cd00054
Location:676 → 709

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1437 → 1472

Syndecan; Syndecan domain

pfam02210
Location:929 → 1057

Laminin_G_2; Laminin G domain
XM_017317294.2 → XP_017172783.1 neurexin-1 isoform X1

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

Conserved Domains (6) summary

smart00294
Location:1461 → 1479

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:503 → 652

LamG; Laminin G domain

cd00054
Location:680 → 713

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1441 → 1480

Syndecan; Syndecan domain

pfam02210
Location:933 → 1058

Laminin_G_2; Laminin G domain
XM_017317306.2 → XP_017172795.1 neurexin-1 isoform X15

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

Conserved Domains (6) summary

smart00294
Location:1441 → 1459

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:483 → 632

LamG; Laminin G domain

cd00054
Location:660 → 693

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1421 → 1456

Syndecan; Syndecan domain

pfam02210
Location:913 → 1041

Laminin_G_2; Laminin G domain
XM_036160388.1 → XP_036016281.1 neurexin-1 isoform X34

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

Conserved Domains (6) summary

smart00294
Location:1416 → 1434

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:491 → 640

LamG; Laminin G domain

cd00054
Location:668 → 701

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1396 → 1431

Syndecan; Syndecan domain

pfam02210
Location:921 → 1049

Laminin_G_2; Laminin G domain
XM_036160369.1 → XP_036016262.1 neurexin-1 isoform X8

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

Conserved Domains (6) summary

smart00294
Location:1449 → 1467

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:491 → 640

LamG; Laminin G domain

cd00054
Location:668 → 701

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1429 → 1464

Syndecan; Syndecan domain

pfam02210
Location:921 → 1049

Laminin_G_2; Laminin G domain
XM_036160390.1 → XP_036016283.1 neurexin-1 isoform X35

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

Conserved Domains (6) summary

smart00294
Location:1415 → 1433

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:499 → 648

LamG; Laminin G domain

cd00054
Location:676 → 709

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1395 → 1430

Syndecan; Syndecan domain

pfam02210
Location:929 → 1057

Laminin_G_2; Laminin G domain
XM_036160387.1 → XP_036016280.1 neurexin-1 isoform X33

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

Conserved Domains (6) summary

smart00294
Location:1418 → 1436

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:499 → 648

LamG; Laminin G domain

cd00054
Location:676 → 709

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1398 → 1433

Syndecan; Syndecan domain

pfam02210
Location:929 → 1057

Laminin_G_2; Laminin G domain
XM_030249558.1 → XP_030105418.1 neurexin-1 isoform X10

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

Conserved Domains (6) summary

smart00294
Location:1445 → 1463

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:499 → 648

LamG; Laminin G domain

cd00054
Location:676 → 709

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1425 → 1464

Syndecan; Syndecan domain

pfam02210
Location:929 → 1054

Laminin_G_2; Laminin G domain
XM_036160379.1 → XP_036016272.1 neurexin-1 isoform X23

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

Conserved Domains (6) summary

smart00294
Location:1427 → 1445

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:499 → 648

LamG; Laminin G domain

cd00054
Location:676 → 709

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1407 → 1442

Syndecan; Syndecan domain

pfam02210
Location:929 → 1057

Laminin_G_2; Laminin G domain
XM_017317297.2 → XP_017172786.1 neurexin-1 isoform X3

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

Conserved Domains (6) summary

smart00294
Location:1457 → 1475

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:499 → 648

LamG; Laminin G domain

cd00054
Location:676 → 709

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1437 → 1472

Syndecan; Syndecan domain

pfam02210
Location:929 → 1057

Laminin_G_2; Laminin G domain
XM_036160373.1 → XP_036016266.1 neurexin-1 isoform X16

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

Conserved Domains (6) summary

smart00294
Location:1441 → 1459

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:495 → 644

LamG; Laminin G domain

cd00054
Location:672 → 705

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1421 → 1456

Syndecan; Syndecan domain

pfam02210
Location:916 → 1044

Laminin_G_2; Laminin G domain
XM_036160372.1 → XP_036016265.1 neurexin-1 isoform X12

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

Conserved Domains (6) summary

smart00294
Location:1444 → 1462

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:495 → 644

LamG; Laminin G domain

cd00054
Location:672 → 705

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1424 → 1459

Syndecan; Syndecan domain

pfam02210
Location:916 → 1044

Laminin_G_2; Laminin G domain
XM_036160391.1 → XP_036016284.1 neurexin-1 isoform X37

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

Conserved Domains (6) summary

smart00294
Location:1411 → 1429

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:495 → 644

LamG; Laminin G domain

cd00054
Location:672 → 705

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1391 → 1426

Syndecan; Syndecan domain

pfam02210
Location:925 → 1053

Laminin_G_2; Laminin G domain
XM_030249561.1 → XP_030105421.1 neurexin-1 isoform X36

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

Conserved Domains (6) summary

smart00294
Location:1414 → 1432

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:495 → 644

LamG; Laminin G domain

cd00054
Location:672 → 705

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1394 → 1433

Syndecan; Syndecan domain

pfam02210
Location:925 → 1050

Laminin_G_2; Laminin G domain
XM_006523812.4 → XP_006523875.1 neurexin-1 isoform X14

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

Related

ENSMUSP00000072458.8, ENSMUST00000072671.14

Conserved Domains (6) summary

smart00294
Location:1441 → 1459

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:495 → 644

LamG; Laminin G domain

cd00054
Location:672 → 705

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1421 → 1460

Syndecan; Syndecan domain

pfam02210
Location:925 → 1050

Laminin_G_2; Laminin G domain
XM_006523811.4 → XP_006523874.1 neurexin-1 isoform X11

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

Related

ENSMUSP00000057294.9, ENSMUST00000054059.15

Conserved Domains (6) summary

smart00294
Location:1444 → 1462

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:495 → 644

LamG; Laminin G domain

cd00054
Location:672 → 705

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1424 → 1463

Syndecan; Syndecan domain

pfam02210
Location:925 → 1050

Laminin_G_2; Laminin G domain
XM_036160384.1 → XP_036016277.1 neurexin-1 isoform X29

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

Conserved Domains (6) summary

smart00294
Location:1420 → 1438

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:495 → 644

LamG; Laminin G domain

cd00054
Location:672 → 705

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1400 → 1435

Syndecan; Syndecan domain

pfam02210
Location:925 → 1053

Laminin_G_2; Laminin G domain
XM_036160381.1 → XP_036016274.1 neurexin-1 isoform X25

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

Conserved Domains (6) summary

smart00294
Location:1423 → 1441

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:495 → 644

LamG; Laminin G domain

cd00054
Location:672 → 705

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1403 → 1438

Syndecan; Syndecan domain

pfam02210
Location:925 → 1053

Laminin_G_2; Laminin G domain
XM_036160368.1 → XP_036016261.1 neurexin-1 isoform X6

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

Conserved Domains (6) summary

smart00294
Location:1450 → 1468

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:495 → 644

LamG; Laminin G domain

cd00054
Location:672 → 705

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1430 → 1465

Syndecan; Syndecan domain

pfam02210
Location:925 → 1053

Laminin_G_2; Laminin G domain
XM_017317300.2 → XP_017172789.1 neurexin-1 isoform X4

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

Conserved Domains (6) summary

smart00294
Location:1453 → 1471

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:495 → 644

LamG; Laminin G domain

cd00054
Location:672 → 705

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1433 → 1472

Syndecan; Syndecan domain

pfam02210
Location:925 → 1050

Laminin_G_2; Laminin G domain
XM_030249559.1 → XP_030105419.1 neurexin-1 isoform X17

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

Conserved Domains (6) summary

smart00294
Location:1440 → 1458

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:503 → 652

LamG; Laminin G domain

cd00054
Location:680 → 713

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1420 → 1459

Syndecan; Syndecan domain

pfam02210
Location:924 → 1049

Laminin_G_2; Laminin G domain
XM_017317304.2 → XP_017172793.1 neurexin-1 isoform X13

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

Conserved Domains (6) summary

smart00294
Location:1443 → 1461

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:503 → 652

LamG; Laminin G domain

cd00054
Location:680 → 713

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1423 → 1462

Syndecan; Syndecan domain

pfam02210
Location:924 → 1049

Laminin_G_2; Laminin G domain
XM_036160386.1 → XP_036016279.1 neurexin-1 isoform X32

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

Conserved Domains (6) summary

smart00294
Location:1419 → 1437

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:503 → 652

LamG; Laminin G domain

cd00054
Location:680 → 713

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1399 → 1434

Syndecan; Syndecan domain

pfam02210
Location:924 → 1052

Laminin_G_2; Laminin G domain
XM_036160382.1 → XP_036016275.1 neurexin-1 isoform X27

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

Conserved Domains (6) summary

smart00294
Location:1422 → 1440

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:503 → 652

LamG; Laminin G domain

cd00054
Location:680 → 713

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1402 → 1437

Syndecan; Syndecan domain

pfam02210
Location:924 → 1052

Laminin_G_2; Laminin G domain
XM_017317301.2 → XP_017172790.1 neurexin-1 isoform X5

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

Conserved Domains (6) summary

smart00294
Location:1452 → 1470

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:503 → 652

LamG; Laminin G domain

cd00054
Location:680 → 713

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1432 → 1471

Syndecan; Syndecan domain

pfam02210
Location:924 → 1049

Laminin_G_2; Laminin G domain
XM_017317310.2 → XP_017172799.1 neurexin-1 isoform X30

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

Conserved Domains (6) summary

smart00294
Location:1419 → 1437

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:503 → 652

LamG; Laminin G domain

cd00054
Location:680 → 713

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1399 → 1438

Syndecan; Syndecan domain

pfam02210
Location:933 → 1058

Laminin_G_2; Laminin G domain
XM_006523816.4 → XP_006523879.1 neurexin-1 isoform X26

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

Related

ENSMUSP00000133491.2, ENSMUST00000174331.8

Conserved Domains (6) summary

smart00294
Location:1422 → 1440

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:503 → 652

LamG; Laminin G domain

cd00054
Location:680 → 713

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1402 → 1441

Syndecan; Syndecan domain

pfam02210
Location:933 → 1058

Laminin_G_2; Laminin G domain
XM_017317303.2 → XP_017172792.1 neurexin-1 isoform X7

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

Conserved Domains (6) summary

smart00294
Location:1449 → 1467

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:503 → 652

LamG; Laminin G domain

cd00054
Location:680 → 713

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1429 → 1468

Syndecan; Syndecan domain

pfam02210
Location:933 → 1058

Laminin_G_2; Laminin G domain
XM_017317309.2 → XP_017172798.1 neurexin-1 isoform X22

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

Conserved Domains (6) summary

smart00294
Location:1428 → 1446

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:503 → 652

LamG; Laminin G domain

cd00054
Location:680 → 713

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1408 → 1447

Syndecan; Syndecan domain

pfam02210
Location:933 → 1058

Laminin_G_2; Laminin G domain
XM_017317308.2 → XP_017172797.1 neurexin-1 isoform X20

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

Conserved Domains (6) summary

smart00294
Location:1431 → 1449

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:503 → 652

LamG; Laminin G domain

cd00054
Location:680 → 713

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1411 → 1450

Syndecan; Syndecan domain

pfam02210
Location:933 → 1058

Laminin_G_2; Laminin G domain
XM_017317296.2 → XP_017172785.1 neurexin-1 isoform X2

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

Conserved Domains (6) summary

smart00294
Location:1458 → 1476

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:503 → 652

LamG; Laminin G domain

cd00054
Location:680 → 713

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1438 → 1477

Syndecan; Syndecan domain

pfam02210
Location:933 → 1058

Laminin_G_2; Laminin G domain
XM_011246318.3 → XP_011244620.1 neurexin-1 isoform X1

UniProtKB/Swiss-Prot

G3UWZ9, O88722, Q80Y87, Q8CHE6, Q9CS84

Conserved Domains (6) summary

smart00294
Location:1461 → 1479

4.1m; putative band 4.1 homologues' binding motif

smart00282
Location:503 → 652

LamG; Laminin G domain

cd00054
Location:680 → 713

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00110
Location:30 → 190

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam01034
Location:1441 → 1480

Syndecan; Syndecan domain

pfam02210
Location:933 → 1058

Laminin_G_2; Laminin G domain