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    Slc13a3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 [ Mus musculus (house mouse) ]

    Gene ID: 114644, updated on 13-Jan-2025

    Summary

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    Official Symbol
    Slc13a3provided by MGI
    Official Full Name
    solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3provided by MGI
    Primary source
    MGI:MGI:2149635
    See related
    Ensembl:ENSMUSG00000018459 AllianceGenome:MGI:2149635
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NaC3; NaDC3; SDCT2; NaDC-3
    Summary
    Enables high-affinity sodium:dicarboxylate symporter activity and succinate transmembrane transporter activity. Involved in succinate transmembrane transport. Acts upstream of or within dicarboxylic acid transport. Located in membrane. Is expressed in several structures, including central nervous system; esophagus; male reproductive gland or organ; metanephros; and retina. Orthologous to human SLC13A3 (solute carrier family 13 member 3). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in kidney adult (RPKM 238.1), liver E18 (RPKM 17.7) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Slc13a3 in Genome Data Viewer
    Location:
    2 H3; 2 85.54 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (165247215..165315117, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (165405295..165473197, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06348 Neighboring gene zinc finger protein 334 Neighboring gene osteoclast stimulatory transmembrane protein Neighboring gene origin of replication near adenosine deaminase Neighboring gene predicted gene 14437 Neighboring gene transformation related protein 53 regulating kinase A Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning and functional characterization of a high-affinity Na(+)/dicarboxylate cotransporter from mouse brain. Pajor AM, et al. Am J Physiol Cell Physiol, 2001 May. PMID 11287335
    2. Ablating the Transporter Sodium-Dependent Dicarboxylate Transporter 3 Prevents Leukodystrophy in Canavan Disease Mice. Wang Y, et al. Ann Neurol, 2021 Nov. PMID 34498299, Free PMC Article
    3. Inhibition of Slug effectively targets leukemia stem cells via the Slc13a3/ROS signaling pathway. Zhang Z, et al. Leukemia, 2020 Feb. PMID 31492896, Free PMC Article
    4. Transport characteristics of N-acetyl-L-aspartate in rat astrocytes: involvement of sodium-coupled high-affinity carboxylate transporter NaC3/NaDC3-mediated transport system. Fujita T, et al. J Neurochem, 2005 May. PMID 15836629
    5. 3-Hydroxyglutaric acid is transported via the sodium-dependent dicarboxylate transporter NaDC3. Stellmer F, et al. J Mol Med (Berl), 2007 Jul. PMID 17356845

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Astroglial conditional Slc13a3 knockout is therapeutic in murine Canavan leukodystrophy.
      Title: Astroglial conditional Slc13a3 knockout is therapeutic in murine Canavan leukodystrophy.
    2. Genetic or pharmacological inhibition of SLUG or forced expression of Slc13a3 suppresses the growth of human AML cells.
      Title: Inhibition of Slug effectively targets leukemia stem cells via the Slc13a3/ROS signaling pathway.
    3. demonstrate the membrane translocation of 3OH-GA mediated by NaDC3 and the cis-inhibitory effect on OCT2-mediated transport of cations
      Title: 3-Hydroxyglutaric acid is transported via the sodium-dependent dicarboxylate transporter NaDC3.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-aspartate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alpha-ketoglutarate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-ketoglutarate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables amide transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables citrate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables citrate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dicarboxylic acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables glutathione transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables high-affinity sodium:dicarboxylate symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables modified amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables organic acid:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables sodium:dicarboxylate symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sodium:dicarboxylate symporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables succinate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables succinate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables succinate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in alpha-ketoglutarate transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aspartate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in carboxylic acid transport ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in citrate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in citrate transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within dicarboxylic acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dicarboxylic acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glutathione transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutathione transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in succinate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in succinate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in succinate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in succinate transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    Na(+)/dicarboxylate cotransporter 3
    Names
    Na(+)-coupled carboxylate transporter 3
    mNaDC3
    sodium-dependent high-affinity dicarboxylate transporter 2
    solute carrier family 13 member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_054055.2 → NP_473396.1  Na(+)/dicarboxylate cotransporter 3

      Status: PROVISIONAL

      Source sequence(s)
      AL591064
      Consensus CDS
      CCDS17081.1
      UniProtKB/Swiss-Prot
      Q91Y63
      UniProtKB/TrEMBL
      A2A4U9, Q3UUJ6
      Related
      ENSMUSP00000029208.9, ENSMUST00000029208.15
      Conserved Domains (2) summary
      cd01115
      Location:42 → 556
      SLC13_permease; Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is ...
      TIGR00785
      Location:31 → 565
      dass; anion transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      165247215..165315117 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91Y63.1 GenPept UniProtKB/Swiss-Prot:Q91Y63

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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