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    MARK3 microtubule affinity regulating kinase 3 [ Homo sapiens (human) ]

    Gene ID: 4140, updated on 27-Nov-2024

    Summary

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    Official Symbol
    MARK3provided by HGNC
    Official Full Name
    microtubule affinity regulating kinase 3provided by HGNC
    Primary source
    HGNC:HGNC:6897
    See related
    Ensembl:ENSG00000075413 MIM:602678; AllianceGenome:HGNC:6897
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KP78; VIPB; CTAK1; PAR1A; Par-1a
    Summary
    The protein encoded by this gene is activated by phosphorylation and in turn is involved in the phosphorylation of tau proteins MAP2 and MAP4. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
    Expression
    Ubiquitous expression in bone marrow (RPKM 22.5), testis (RPKM 17.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MARK3 in Genome Data Viewer
    Location:
    14q32.32-q32.33
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (103385415..103503831)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (97621350..97739863)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (103851752..103970168)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103838386-103839043 Neighboring gene high mobility group box 3 pseudogene 26 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103850577-103851568 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103851569-103852558 Neighboring gene ribosomal protein SA pseudogene 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103866087-103866886 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6152 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6153 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9103 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9104 Neighboring gene ribosomal protein L10a pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103921390-103921890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103921891-103922391 Neighboring gene uncharacterized LOC112268130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:103984081-103984968 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:103986745-103987632 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6155 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6156 Neighboring gene creatine kinase B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Genetic analysis of recently identified osteoporosis susceptibility genes in southern Chinese. Xiao SM, et al. J Clin Endocrinol Metab, 2013 Nov. PMID 23894155
    2. Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain. Murphy JM, et al. Proc Natl Acad Sci U S A, 2007 Sep 4. PMID 17726107, Free PMC Article
    3. Assignment of MARK3 alias KP78 to human chromosome band 14q32.3 by in situ hybridization. Ono T, et al. Cytogenet Cell Genet, 1997. PMID 9533022
    4. The metabolic stress-activated checkpoint LKB1-MARK3 axis acts as a tumor suppressor in high-grade serous ovarian carcinoma. Machino H, et al. Commun Biol, 2022 Jan 11. PMID 35017636, Free PMC Article
    5. Visual impairment and progressive phthisis bulbi caused by recessive pathogenic variant in MARK3. Ansar M, et al. Hum Mol Genet, 2018 Aug 1. PMID 29771303, Free PMC Article

    See all (129) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interaction between MARK3 (rs11623869), PLCB4 (rs6086746) and GEMIN2 (rs2277458) variants with bone mineral density and serum 25-hidroxivitamin D levels in Mexican Mestizo women.
      Title: Interaction between MARK3 (rs11623869), PLCB4 (rs6086746) and GEMIN2 (rs2277458) variants with bone mineral density and serum 25-hidroxivitamin D levels in Mexican Mestizo women.
    2. The metabolic stress-activated checkpoint LKB1-MARK3 axis acts as a tumor suppressor in high-grade serous ovarian carcinoma.
      Title: The metabolic stress-activated checkpoint LKB1-MARK3 axis acts as a tumor suppressor in high-grade serous ovarian carcinoma.
    3. A non-synonymous homozygous variant (NM_001128918.2: c.1708C > G: p.Arg570Gly) in the MARK3 leads to visual impairment and progressive phthisis bulbi.
      Title: Visual impairment and progressive phthisis bulbi caused by recessive pathogenic variant in MARK3.
    4. Authors identified a regulatory switch controlled by MARK3 that couples microtubules to the actin cytoskeleton to establish epithelial cell polarity through ARHGEF2.
      Title: MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity.
    5. findings indicate that brain PP-1I associates with and is regulated by the associated protein kinases C-TAK1 and PFTK1
      Title: Regulation of protein phosphatase 1I by Cdc25C-associated kinase 1 (C-TAK1) and PFTAIRE protein kinase.
    6. We have shown that serum ALP levels modified the association of MARK3 with bone mineral density in osetoporosis for Chinese patients.
      Title: Genetic analysis of recently identified osteoporosis susceptibility genes in southern Chinese.
    7. Observational study of gene-disease association. (HuGE Navigator)
      Title: Analysis of recently identified osteoporosis susceptibility genes in Han Chinese women.
    8. Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
      Title: OPG and RANK polymorphisms are both associated with cortical bone mineral density: findings from a metaanalysis of the Avon longitudinal study of parents and children and gothenburg osteoporosis and obesity determinants cohorts.
    9. interaction between Mitf and C-TAK1 was demonstrated.
      Title: C-TAK1 interacts with microphthalmia-associated transcription factor, Mitf, but not the related family member Tfe3.
    10. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: New sequence variants associated with bone mineral density.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Visual impairment and progressive phthisis bulbi
    MedGen: C4748978 OMIM: 618283 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tau protein binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables tau-protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tau-protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables tau-protein kinase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of hippo signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of protein localization to nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidyl-serine autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular exosome HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    MAP/microtubule affinity-regulating kinase 3
    Names
    C-TAK1
    ELKL motif kinase 2
    EMK-2
    cdc25C-associated protein kinase 1
    protein kinase STK10
    ser/Thr protein kinase PAR-1
    serine/threonine-protein kinase p78
    NP_001122390.2
    NP_001122391.2
    NP_001122392.2
    NP_001122393.2
    NP_001397984.1
    NP_001397985.1
    NP_002367.5
    XP_005267698.2
    XP_005267699.2
    XP_005267700.2
    XP_011535071.1
    XP_016876780.1
    XP_016876781.1
    XP_016876783.1
    XP_016876784.1
    XP_016876786.1
    XP_016876787.1
    XP_016876788.1
    XP_016876790.1
    XP_047287333.1
    XP_047287334.1
    XP_047287335.1
    XP_047287337.1
    XP_047287338.1
    XP_047287339.1
    XP_047287340.1
    XP_047287341.1
    XP_047287342.1
    XP_047287343.1
    XP_047287344.1
    XP_047287345.1
    XP_047287346.1
    XP_047287347.1
    XP_047287348.1
    XP_047287349.1
    XP_047287350.1
    XP_047287351.1
    XP_047287352.1
    XP_054232027.1
    XP_054232028.1
    XP_054232029.1
    XP_054232030.1
    XP_054232031.1
    XP_054232032.1
    XP_054232033.1
    XP_054232034.1
    XP_054232035.1
    XP_054232036.1
    XP_054232037.1
    XP_054232038.1
    XP_054232039.1
    XP_054232040.1
    XP_054232041.1
    XP_054232042.1
    XP_054232043.1
    XP_054232044.1
    XP_054232045.1
    XP_054232046.1
    XP_054232047.1
    XP_054232048.1
    XP_054232049.1
    XP_054232050.1
    XP_054232051.1
    XP_054232052.1
    XP_054232053.1
    XP_054232054.1
    XP_054232055.1
    XP_054232056.1
    XP_054232057.1
    XP_054232058.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030339.2 RefSeqGene

      Range
      5052..123468
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001128918.3 → NP_001122390.2  MAP/microtubule affinity-regulating kinase 3 isoform a

      See identical proteins and their annotated locations for NP_001122390.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AF465413, AL133367, BC024773, BX248250, DA707357
      Consensus CDS
      CCDS45165.1
      UniProtKB/Swiss-Prot
      A0A0A0MQR8, A0A0A0MST9, A0A0A0MT23, O60219, P27448, Q86TT8, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34
      UniProtKB/TrEMBL
      J3KNR0
      Related
      ENSP00000411397.2, ENST00000429436.7
      Conserved Domains (3) summary
      cd12196
      Location:654 → 751
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14407
      Location:325 → 367
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cd14072
      Location:55 → 307
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    2. NM_001128919.3 → NP_001122391.2  MAP/microtubule affinity-regulating kinase 3 isoform b

      See identical proteins and their annotated locations for NP_001122391.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AF387637, AF465413, AL133367, BC024773, BX248250, DA707357
      Consensus CDS
      CCDS45166.1
      UniProtKB/TrEMBL
      J3KNR0
      Related
      ENSP00000450772.1, ENST00000553942.5
      Conserved Domains (3) summary
      cd12196
      Location:645 → 742
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14407
      Location:325 → 367
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cd14072
      Location:55 → 307
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    3. NM_001128920.3 → NP_001122392.2  MAP/microtubule affinity-regulating kinase 3 isoform d

      See identical proteins and their annotated locations for NP_001122392.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (d) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AL133367, BC024773, DA707357, M80359
      Consensus CDS
      CCDS55947.1
      UniProtKB/TrEMBL
      J3KNR0
      Related
      ENSP00000216288.7, ENST00000216288.11
      Conserved Domains (3) summary
      cd12196
      Location:614 → 711
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14407
      Location:325 → 367
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cd14072
      Location:55 → 307
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    4. NM_001128921.3 → NP_001122393.2  MAP/microtubule affinity-regulating kinase 3 isoform e

      See identical proteins and their annotated locations for NP_001122393.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon and uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (e) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AL133367, BC024773, BX161395, DA707357, KF456011
      Consensus CDS
      CCDS45167.1
      UniProtKB/TrEMBL
      J3KNR0
      Related
      ENSP00000402104.3, ENST00000440884.7
      Conserved Domains (4) summary
      cd12196
      Location:560 → 657
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:56 → 228
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14407
      Location:246 → 288
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cl21453
      Location:55 → 228
      PKc_like; Protein Kinases, catalytic domain

    5. NM_001411055.1 → NP_001397984.1  MAP/microtubule affinity-regulating kinase 3 isoform f

      Status: REVIEWED

      Source sequence(s)
      AL133367, KF456011
      Consensus CDS
      CCDS91938.1
      UniProtKB/TrEMBL
      A0A7I2V2N8
      Related
      ENSP00000502999.1, ENST00000677432.1

    6. NM_001411056.1 → NP_001397985.1  MAP/microtubule affinity-regulating kinase 3 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL133367, KF456011
      Consensus CDS
      CCDS91940.1
      UniProtKB/TrEMBL
      A0A7I2V5G3
      Related
      ENSP00000504493.1, ENST00000678619.1

    7. NM_002376.7 → NP_002367.5  MAP/microtubule affinity-regulating kinase 3 isoform c

      See identical proteins and their annotated locations for NP_002367.5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AL133367, BC024773, DA707357
      Consensus CDS
      CCDS41993.1
      UniProtKB/TrEMBL
      J3KNR0
      Related
      ENSP00000303698.9, ENST00000303622.13
      Conserved Domains (3) summary
      cd12196
      Location:630 → 727
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14407
      Location:325 → 367
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cd14072
      Location:55 → 307
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      103385415..103503831
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005267641.6 → XP_005267698.2  MAP/microtubule affinity-regulating kinase 3 isoform X2

      UniProtKB/TrEMBL
      A0A7I2YQF7, J3KNR0
      Related
      ENSP00000503568.1, ENST00000676938.1
      Conserved Domains (3) summary
      cd12196
      Location:639 → 736
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14407
      Location:325 → 367
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cd14072
      Location:55 → 307
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    2. XM_005267643.6 → XP_005267700.2  MAP/microtubule affinity-regulating kinase 3 isoform X24

      UniProtKB/TrEMBL
      H0YNV4, J3KNR0
      Related
      ENSP00000454169.2, ENST00000560417.6
      Conserved Domains (3) summary
      cd12196
      Location:544 → 641
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14407
      Location:325 → 367
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cd14072
      Location:55 → 307
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    3. XM_005267642.6 → XP_005267699.2  MAP/microtubule affinity-regulating kinase 3 isoform X3

      See identical proteins and their annotated locations for XP_005267699.2

      UniProtKB/TrEMBL
      J3KNR0
      Related
      ENSP00000451623.2, ENST00000556744.2
      Conserved Domains (3) summary
      cd12196
      Location:638 → 735
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14407
      Location:325 → 367
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cd14072
      Location:55 → 307
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    4. XM_017021292.3 → XP_016876781.1  MAP/microtubule affinity-regulating kinase 3 isoform X8

      UniProtKB/TrEMBL
      J3KNR0

    5. XM_017021291.3 → XP_016876780.1  MAP/microtubule affinity-regulating kinase 3 isoform X6

      UniProtKB/TrEMBL
      J3KNR0
      Related
      ENSP00000504859.1, ENST00000678175.1

    6. XM_047431391.1 → XP_047287347.1  MAP/microtubule affinity-regulating kinase 3 isoform X25

    7. XM_047431378.1 → XP_047287334.1  MAP/microtubule affinity-regulating kinase 3 isoform X4

    8. XM_047431382.1 → XP_047287338.1  MAP/microtubule affinity-regulating kinase 3 isoform X9

    9. XM_047431384.1 → XP_047287340.1  MAP/microtubule affinity-regulating kinase 3 isoform X11

    10. XM_047431392.1 → XP_047287348.1  MAP/microtubule affinity-regulating kinase 3 isoform X26

    11. XM_047431388.1 → XP_047287344.1  MAP/microtubule affinity-regulating kinase 3 isoform X15

    12. XM_017021294.3 → XP_016876783.1  MAP/microtubule affinity-regulating kinase 3 isoform X16

      UniProtKB/TrEMBL
      A0A7I2V4G7, A0A7I2V639
      Related
      ENSP00000504622.1, ENST00000677360.1

    13. XM_017021295.3 → XP_016876784.1  MAP/microtubule affinity-regulating kinase 3 isoform X17

      UniProtKB/TrEMBL
      A0A7I2V4G7

    14. XM_017021298.3 → XP_016876787.1  MAP/microtubule affinity-regulating kinase 3 isoform X20

      UniProtKB/TrEMBL
      A0A7I2V3B9, H0YKP9
      Related
      ENSP00000503216.1, ENST00000677829.1

    15. XM_017021297.3 → XP_016876786.1  MAP/microtubule affinity-regulating kinase 3 isoform X18

      UniProtKB/TrEMBL
      A0A7I2V4G7

    16. XM_017021299.3 → XP_016876788.1  MAP/microtubule affinity-regulating kinase 3 isoform X21

      UniProtKB/TrEMBL
      A0A7I2V4G7

    17. XM_047431390.1 → XP_047287346.1  MAP/microtubule affinity-regulating kinase 3 isoform X23

    18. XM_017021301.3 → XP_016876790.1  MAP/microtubule affinity-regulating kinase 3 isoform X27

      UniProtKB/TrEMBL
      A0A7I2V2E3, A0A7I2V4G7
      Related
      ENSP00000502861.1, ENST00000678237.1
      Conserved Domains (3) summary
      cd12196
      Location:523 → 620
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14407
      Location:194 → 236
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cl21453
      Location:1 → 176
      PKc_like; Protein Kinases, catalytic domain

    19. XM_047431386.1 → XP_047287342.1  MAP/microtubule affinity-regulating kinase 3 isoform X13

    20. XM_047431381.1 → XP_047287337.1  MAP/microtubule affinity-regulating kinase 3 isoform X7

    21. XM_047431385.1 → XP_047287341.1  MAP/microtubule affinity-regulating kinase 3 isoform X12

    22. XM_047431377.1 → XP_047287333.1  MAP/microtubule affinity-regulating kinase 3 isoform X1

    23. XM_047431379.1 → XP_047287335.1  MAP/microtubule affinity-regulating kinase 3 isoform X5

    24. XM_047431387.1 → XP_047287343.1  MAP/microtubule affinity-regulating kinase 3 isoform X14

    25. XM_047431383.1 → XP_047287339.1  MAP/microtubule affinity-regulating kinase 3 isoform X10

    26. XM_047431389.1 → XP_047287345.1  MAP/microtubule affinity-regulating kinase 3 isoform X22

    27. XM_011536769.4 → XP_011535071.1  MAP/microtubule affinity-regulating kinase 3 isoform X19

      UniProtKB/TrEMBL
      A0A7I2V4G7
      Related
      ENST00000676745.1
      Conserved Domains (4) summary
      cd12196
      Location:574 → 671
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      COG0515
      Location:2 → 328
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14407
      Location:245 → 287
      UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
      cl21453
      Location:2 → 227
      PKc_like; Protein Kinases, catalytic domain

    28. XM_047431394.1 → XP_047287350.1  MAP/microtubule affinity-regulating kinase 3 isoform X28

    29. XM_047431393.1 → XP_047287349.1  MAP/microtubule affinity-regulating kinase 3 isoform X28

    30. XM_047431396.1 → XP_047287352.1  MAP/microtubule affinity-regulating kinase 3 isoform X30

    31. XM_047431395.1 → XP_047287351.1  MAP/microtubule affinity-regulating kinase 3 isoform X29

      Related
      ENSP00000450460.1, ENST00000554627.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      97621350..97739863
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376053.1 → XP_054232028.1  MAP/microtubule affinity-regulating kinase 3 isoform X2

      UniProtKB/TrEMBL
      A0A7I2YQF7

    2. XM_054376075.1 → XP_054232050.1  MAP/microtubule affinity-regulating kinase 3 isoform X24

      UniProtKB/TrEMBL
      H0YNV4

    3. XM_054376054.1 → XP_054232029.1  MAP/microtubule affinity-regulating kinase 3 isoform X3

    4. XM_054376059.1 → XP_054232034.1  MAP/microtubule affinity-regulating kinase 3 isoform X8

    5. XM_054376057.1 → XP_054232032.1  MAP/microtubule affinity-regulating kinase 3 isoform X6

    6. XM_054376076.1 → XP_054232051.1  MAP/microtubule affinity-regulating kinase 3 isoform X25

    7. XM_054376055.1 → XP_054232030.1  MAP/microtubule affinity-regulating kinase 3 isoform X4

    8. XM_054376060.1 → XP_054232035.1  MAP/microtubule affinity-regulating kinase 3 isoform X9

    9. XM_054376062.1 → XP_054232037.1  MAP/microtubule affinity-regulating kinase 3 isoform X11

    10. XM_054376077.1 → XP_054232052.1  MAP/microtubule affinity-regulating kinase 3 isoform X26

    11. XM_054376066.1 → XP_054232041.1  MAP/microtubule affinity-regulating kinase 3 isoform X15

    12. XM_054376067.1 → XP_054232042.1  MAP/microtubule affinity-regulating kinase 3 isoform X16

      UniProtKB/TrEMBL
      A0A7I2V639

    13. XM_054376068.1 → XP_054232043.1  MAP/microtubule affinity-regulating kinase 3 isoform X17

    14. XM_054376071.1 → XP_054232046.1  MAP/microtubule affinity-regulating kinase 3 isoform X20

      UniProtKB/TrEMBL
      A0A7I2V3B9

    15. XM_054376069.1 → XP_054232044.1  MAP/microtubule affinity-regulating kinase 3 isoform X18

    16. XM_054376072.1 → XP_054232047.1  MAP/microtubule affinity-regulating kinase 3 isoform X21

    17. XM_054376074.1 → XP_054232049.1  MAP/microtubule affinity-regulating kinase 3 isoform X23

    18. XM_054376078.1 → XP_054232053.1  MAP/microtubule affinity-regulating kinase 3 isoform X27

      UniProtKB/TrEMBL
      A0A7I2V2E3

    19. XM_054376064.1 → XP_054232039.1  MAP/microtubule affinity-regulating kinase 3 isoform X13

    20. XM_054376058.1 → XP_054232033.1  MAP/microtubule affinity-regulating kinase 3 isoform X7

    21. XM_054376063.1 → XP_054232038.1  MAP/microtubule affinity-regulating kinase 3 isoform X12

    22. XM_054376052.1 → XP_054232027.1  MAP/microtubule affinity-regulating kinase 3 isoform X1

    23. XM_054376056.1 → XP_054232031.1  MAP/microtubule affinity-regulating kinase 3 isoform X5

    24. XM_054376065.1 → XP_054232040.1  MAP/microtubule affinity-regulating kinase 3 isoform X14

    25. XM_054376061.1 → XP_054232036.1  MAP/microtubule affinity-regulating kinase 3 isoform X10

    26. XM_054376073.1 → XP_054232048.1  MAP/microtubule affinity-regulating kinase 3 isoform X22

    27. XM_054376070.1 → XP_054232045.1  MAP/microtubule affinity-regulating kinase 3 isoform X19

    28. XM_054376081.1 → XP_054232056.1  MAP/microtubule affinity-regulating kinase 3 isoform X28

    29. XM_054376080.1 → XP_054232055.1  MAP/microtubule affinity-regulating kinase 3 isoform X28

    30. XM_054376079.1 → XP_054232054.1  MAP/microtubule affinity-regulating kinase 3 isoform X31

    31. XM_054376083.1 → XP_054232058.1  MAP/microtubule affinity-regulating kinase 3 isoform X30

    32. XM_054376082.1 → XP_054232057.1  MAP/microtubule affinity-regulating kinase 3 isoform X29

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27448.5 GenPept UniProtKB/Swiss-Prot:P27448

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