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    COMMD4 COMM domain containing 4 [ Homo sapiens (human) ]

    Gene ID: 54939, updated on 10-Dec-2024

    Summary

    Official Symbol
    COMMD4provided by HGNC
    Official Full Name
    COMM domain containing 4provided by HGNC
    Primary source
    HGNC:HGNC:26027
    See related
    Ensembl:ENSG00000140365 MIM:616701; AllianceGenome:HGNC:26027
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Located in cytosol; intracellular membrane-bounded organelle; and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 15.5), adrenal (RPKM 11.9) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See COMMD4 in Genome Data Viewer
    Location:
    15q24.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (75336063..75343227)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (73206125..73213288)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (75628404..75635568)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene dynamin 1 pseudogene 34 Neighboring gene acidic nuclear phosphoprotein 32 family member B pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:75622279-75622435 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9847 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9848 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9849 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6666 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9850 Neighboring gene nei like DNA glycosylase 1 Neighboring gene Sharpr-MPRA regulatory region 1822 Neighboring gene microRNA 631 Neighboring gene mannosidase alpha class 2C member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6667 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75660721-75661253

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    General gene information

    Clone Names

    • FLJ20452

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in signal transduction  
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytosol  
    located_in intracellular membrane-bounded organelle  
    located_in nucleus  
    located_in plasma membrane  

    General protein information

    Preferred Names
    COMM domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001284377.2 → NP_001271306.1  COMM domain-containing protein 4 isoform 2

      See identical proteins and their annotated locations for NP_001271306.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK000459
      Consensus CDS
      CCDS66834.1
      UniProtKB/Swiss-Prot
      Q9H0A8
      Related
      ENSP00000340867.6, ENST00000338995.10
      Conserved Domains (1) summary
      cl06336
      Location:25 → 127
      Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...
    2. NM_001284378.2 → NP_001271307.1  COMM domain-containing protein 4 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AW117823, BI829264
      Consensus CDS
      CCDS66835.1
      UniProtKB/Swiss-Prot
      Q9H0A8
      Related
      ENSP00000457693.1, ENST00000567195.5
      Conserved Domains (1) summary
      cl06336
      Location:25 → 101
      Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...
    3. NM_001284379.2 → NP_001271308.1  COMM domain-containing protein 4 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, contains multiple differences in the coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC068338, AW117823, BQ233598, DB524201, HY162014
      Consensus CDS
      CCDS73764.1
      UniProtKB/TrEMBL
      H3BQF2
      Related
      ENSP00000455750.1, ENST00000562789.5
      Conserved Domains (1) summary
      cl06336
      Location:31 → 133
      Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...
    4. NM_001321844.2 → NP_001308773.1  COMM domain-containing protein 4 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC068338
      Conserved Domains (1) summary
      cd04752
      Location:1 → 174
      Commd4; COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...
    5. NM_001321845.2 → NP_001308774.1  COMM domain-containing protein 4 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC068338
      Conserved Domains (1) summary
      cl06336
      Location:2 → 152
      Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...
    6. NM_001321846.2 → NP_001308775.1  COMM domain-containing protein 4 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC068338
      Conserved Domains (1) summary
      cl06336
      Location:26 → 105
      Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...
    7. NM_001321847.2 → NP_001308776.1  COMM domain-containing protein 4 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC068338
      Consensus CDS
      CCDS81909.1
      UniProtKB/TrEMBL
      A0A0B4J287
      Related
      ENSP00000455249.1, ENST00000564815.5
      Conserved Domains (1) summary
      cl06336
      Location:26 → 176
      Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...
    8. NM_001321848.2 → NP_001308777.1  COMM domain-containing protein 4 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC068338
      UniProtKB/TrEMBL
      H3BM91
      Conserved Domains (1) summary
      cd04752
      Location:31 → 204
      Commd4; COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...
    9. NM_017828.5 → NP_060298.2  COMM domain-containing protein 4 isoform 1

      See identical proteins and their annotated locations for NP_060298.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform (1).
      Source sequence(s)
      BC068998, BI829484
      Consensus CDS
      CCDS10277.1
      UniProtKB/Swiss-Prot
      B2RBN4, H3BUL2, Q7L637, Q9H0A8, Q9NX43
      UniProtKB/TrEMBL
      H3BM91
      Related
      ENSP00000267935.8, ENST00000267935.13
      Conserved Domains (1) summary
      cd04752
      Location:25 → 198
      Commd4; COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...

    RNA

    1. NR_104312.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC068338, AL136872, BI829484
    2. NR_104313.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AW117823, BU540913, DB524201
      Related
      ENST00000562610.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      75336063..75343227
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011521739.3 → XP_011520041.1  COMM domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      H3BM91
      Conserved Domains (1) summary
      cd04752
      Location:55 → 228
      Commd4; COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...
    2. XM_011521741.3 → XP_011520043.1  COMM domain-containing protein 4 isoform X5

      Conserved Domains (1) summary
      cl06336
      Location:55 → 157
      Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...
    3. XM_011521740.2 → XP_011520042.1  COMM domain-containing protein 4 isoform X3

      UniProtKB/TrEMBL
      H3BM91
      Conserved Domains (1) summary
      cl06336
      Location:56 → 206
      Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...
    4. XM_017022385.2 → XP_016877874.1  COMM domain-containing protein 4 isoform X6

    5. XM_005254509.4 → XP_005254566.1  COMM domain-containing protein 4 isoform X2

      UniProtKB/TrEMBL
      H3BM91
      Related
      ENSP00000454283.1, ENST00000568301.1
      Conserved Domains (1) summary
      cd04752
      Location:52 → 225
      Commd4; COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...
    6. XM_005254510.4 → XP_005254567.1  COMM domain-containing protein 4 isoform X4

      UniProtKB/TrEMBL
      H3BM91
      Conserved Domains (1) summary
      cl06336
      Location:53 → 203
      Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      73206125..73213288
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054378325.1 → XP_054234300.1  COMM domain-containing protein 4 isoform X2

      UniProtKB/TrEMBL
      H3BM91
    2. XM_054378324.1 → XP_054234299.1  COMM domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      H3BM91
    3. XM_054378328.1 → XP_054234303.1  COMM domain-containing protein 4 isoform X5

    4. XM_054378326.1 → XP_054234301.1  COMM domain-containing protein 4 isoform X3

      UniProtKB/TrEMBL
      H3BM91
    5. XM_054378327.1 → XP_054234302.1  COMM domain-containing protein 4 isoform X4

      UniProtKB/TrEMBL
      H3BM91
    6. XM_054378329.1 → XP_054234304.1  COMM domain-containing protein 4 isoform X6

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