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    TRIM3 tripartite motif containing 3 [ Homo sapiens (human) ]

    Gene ID: 10612, updated on 27-Nov-2024

    Summary

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    Official Symbol
    TRIM3provided by HGNC
    Official Full Name
    tripartite motif containing 3provided by HGNC
    Primary source
    HGNC:HGNC:10064
    See related
    Ensembl:ENSG00000110171 MIM:605493; AllianceGenome:HGNC:10064
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BERP; HAC1; RNF22; RNF97
    Summary
    The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in duodenum (RPKM 6.6), small intestine (RPKM 6.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TRIM3 in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (6448613..6474459, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (6507075..6532930, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6469843..6495689, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene amyloid beta precursor protein binding family B member 1 Neighboring gene Sharpr-MPRA regulatory region 8482 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3100 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3101 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4340 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3102 Neighboring gene hemopexin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4341 Neighboring gene Sharpr-MPRA regulatory region 6512 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:6493832-6494771 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:6494772-6495710 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:6502154-6503353 Neighboring gene ARF interacting protein 2 Neighboring gene translocase of inner mitochondrial membrane 10B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Decreased expression of TRIM3 is associated with poor prognosis in patients with primary hepatocellular carcinoma. Chao J, et al. Med Oncol, 2014 Aug. PMID 24994609
    2. Decreased expression of TRIM3 gene predicts a poor prognosis in gastric cancer. Farhadi J, et al. J Gastrointest Cancer, 2022 Mar. PMID 33415720
    3. Exosomal TRIM3 is a novel marker and therapy target for gastric cancer. Fu H, et al. J Exp Clin Cancer Res, 2018 Jul 21. PMID 30031392, Free PMC Article
    4. TRIM3 Inhibits H(2)O(2)-Induced Apoptosis in Human Lens Epithelial Cells by Decreasing p53 via Ubiquitination. Deng Y, et al. Curr Eye Res, 2022 May. PMID 35317686
    5. Tripartite motif-containing protein 3 plays a role of tumor inhibitor in cervical cancer. Song Y, et al. Biochem Biophys Res Commun, 2018 Apr 6. PMID 29524410

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tripartite-motif 3 represses ovarian cancer progression by downregulating lactate dehydrogenase A and inhibiting AKT signaling.
      Title: Tripartite-motif 3 represses ovarian cancer progression by downregulating lactate dehydrogenase A and inhibiting AKT signaling.
    2. Advances in the antitumor mechanisms of tripartite motif-containing protein 3.
      Title: Advances in the antitumor mechanisms of tripartite motif-containing protein 3.
    3. TRIM3 facilitates ferroptosis in non-small cell lung cancer through promoting SLC7A11/xCT K11-linked ubiquitination and degradation.
      Title: TRIM3 facilitates ferroptosis in non-small cell lung cancer through promoting SLC7A11/xCT K11-linked ubiquitination and degradation.
    4. Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity.
      Title: Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity.
    5. TRIM3 Inhibits H2O2-Induced Apoptosis in Human Lens Epithelial Cells by Decreasing p53 via Ubiquitination.
      Title: TRIM3 Inhibits H(2)O(2)-Induced Apoptosis in Human Lens Epithelial Cells by Decreasing p53 via Ubiquitination.
    6. TRIM3 facilitates estrogen signaling and modulates breast cancer cell progression.
      Title: TRIM3 facilitates estrogen signaling and modulates breast cancer cell progression.
    7. Decreased expression of TRIM3 gene predicts a poor prognosis in gastric cancer.
      Title: Decreased expression of TRIM3 gene predicts a poor prognosis in gastric cancer.
    8. TRIM3 attenuates apoptosis in Parkinson's disease via activating PI3K/AKT signal pathway.
      Title: TRIM3 attenuates apoptosis in Parkinson's disease via activating PI3K/AKT signal pathway.
    9. miR-454-3p promotes proliferation and induces apoptosis in human cervical cancer cells by targeting TRIM3.
      Title: miR-454-3p promotes proliferation and induces apoptosis in human cervical cancer cells by targeting TRIM3.
    10. Foxo3a exerted inhibitory effects on LPS-induced proliferation and inflammation through increasing TRIM3 transcription.
      Title: Forkhead box o3a suppresses lipopolysaccharide-stimulated proliferation and inflammation in fibroblast-like synoviocytes through regulating tripartite motif-containing protein 3.
    Submit: New GeneRIF Correction See all GeneRIFs (27)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ16135

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nervous system development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of toll-like receptor 3 signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K63-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tripartite motif-containing protein 3
    Names
    RING finger protein 97
    brain expressed ring finger
    brain-expressed RING finger protein
    ring finger protein 22
    tripartite motif protein TRIM3
    NP_001234935.1
    NP_001234936.1
    NP_006449.2
    NP_150594.2
    XP_016872587.1
    XP_024304096.1
    XP_047282213.1
    XP_047282214.1
    XP_047282215.1
    XP_047282217.1
    XP_047282218.1
    XP_054223451.1
    XP_054223452.1
    XP_054223453.1
    XP_054223454.1
    XP_054223455.1
    XP_054223456.1
    XP_054223457.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001248006.2 → NP_001234935.1  tripartite motif-containing protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001234935.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains a different 5' UTR, compared to variant 1. Variants 1, 2, and 4 encode the same protein (isoform 1).
      Source sequence(s)
      AC084337
      Consensus CDS
      CCDS7764.1
      UniProtKB/Swiss-Prot
      B7Z5E6, F5H2Q8, O75382, Q4V9L4, Q9C038, Q9C039
      UniProtKB/TrEMBL
      B7Z5Y8
      Related
      ENSP00000433102.1, ENST00000525074.5
      Conserved Domains (5) summary
      smart00502
      Location:158 → 284
      BBC; B-Box C-terminal domain
      smart00336
      Location:110 → 151
      BBOX; B-Box-type zinc finger
      smart00557
      Location:322 → 419
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:471 → 744
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16768
      Location:19 → 63
      RING-HC_TRIM3; RING finger, HC subclass, found in tripartite motif-containing protein 3 (TRIM3)

    2. NM_001248007.2 → NP_001234936.1  tripartite motif-containing protein 3 isoform 2

      See identical proteins and their annotated locations for NP_001234936.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks several exons, which results in translation initiation at a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AK291396, AK298843, AK299586, AL122053, BC096827
      Consensus CDS
      CCDS58115.1
      UniProtKB/Swiss-Prot
      O75382
      UniProtKB/TrEMBL
      B7Z5Y8
      Related
      ENSP00000445460.1, ENST00000536344.5
      Conserved Domains (4) summary
      smart00502
      Location:39 → 165
      BBC; B-Box C-terminal domain
      smart00557
      Location:203 → 300
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:352 → 625
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cl00034
      Location:2 → 34
      Bbox_SF; B-box-type zinc finger superfamily

    3. NM_006458.4 → NP_006449.2  tripartite motif-containing protein 3 isoform 1

      See identical proteins and their annotated locations for NP_006449.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 4 encode the same protein (isoform 1).
      Source sequence(s)
      AK291396, AK299586, AL122053, BC096827, BI916995
      Consensus CDS
      CCDS7764.1
      UniProtKB/Swiss-Prot
      B7Z5E6, F5H2Q8, O75382, Q4V9L4, Q9C038, Q9C039
      UniProtKB/TrEMBL
      B7Z5Y8
      Related
      ENSP00000352508.3, ENST00000359518.7
      Conserved Domains (5) summary
      smart00502
      Location:158 → 284
      BBC; B-Box C-terminal domain
      smart00336
      Location:110 → 151
      BBOX; B-Box-type zinc finger
      smart00557
      Location:322 → 419
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:471 → 744
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16768
      Location:19 → 63
      RING-HC_TRIM3; RING finger, HC subclass, found in tripartite motif-containing protein 3 (TRIM3)

    4. NM_033278.4 → NP_150594.2  tripartite motif-containing protein 3 isoform 1

      See identical proteins and their annotated locations for NP_150594.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode the same protein (isoform 1).
      Source sequence(s)
      AL122053, BC096827, BM758857, DA089323, DA347370, DB344600
      Consensus CDS
      CCDS7764.1
      UniProtKB/Swiss-Prot
      B7Z5E6, F5H2Q8, O75382, Q4V9L4, Q9C038, Q9C039
      UniProtKB/TrEMBL
      B7Z5Y8
      Related
      ENSP00000340797.3, ENST00000345851.8
      Conserved Domains (5) summary
      smart00502
      Location:158 → 284
      BBC; B-Box C-terminal domain
      smart00336
      Location:110 → 151
      BBOX; B-Box-type zinc finger
      smart00557
      Location:322 → 419
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:471 → 744
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16768
      Location:19 → 63
      RING-HC_TRIM3; RING finger, HC subclass, found in tripartite motif-containing protein 3 (TRIM3)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      6448613..6474459 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047426261.1 → XP_047282217.1  tripartite motif-containing protein 3 isoform X4

    2. XM_024448328.2 → XP_024304096.1  tripartite motif-containing protein 3 isoform X3

      UniProtKB/Swiss-Prot
      B7Z5E6, F5H2Q8, O75382, Q4V9L4, Q9C038, Q9C039
      UniProtKB/TrEMBL
      B7Z5Y8
      Conserved Domains (5) summary
      smart00502
      Location:158 → 284
      BBC; B-Box C-terminal domain
      smart00336
      Location:110 → 151
      BBOX; B-Box-type zinc finger
      smart00557
      Location:322 → 419
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:471 → 744
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16768
      Location:19 → 63
      RING-HC_TRIM3; RING finger, HC subclass, found in tripartite motif-containing protein 3 (TRIM3)

    3. XM_017017098.3 → XP_016872587.1  tripartite motif-containing protein 3 isoform X3

      UniProtKB/Swiss-Prot
      B7Z5E6, F5H2Q8, O75382, Q4V9L4, Q9C038, Q9C039
      UniProtKB/TrEMBL
      B7Z5Y8
      Conserved Domains (5) summary
      smart00502
      Location:158 → 284
      BBC; B-Box C-terminal domain
      smart00336
      Location:110 → 151
      BBOX; B-Box-type zinc finger
      smart00557
      Location:322 → 419
      IG_FLMN; Filamin-type immunoglobulin domains
      cd14960
      Location:471 → 744
      NHL_TRIM2_like; NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins
      cd16768
      Location:19 → 63
      RING-HC_TRIM3; RING finger, HC subclass, found in tripartite motif-containing protein 3 (TRIM3)

    4. XM_047426258.1 → XP_047282214.1  tripartite motif-containing protein 3 isoform X2

    5. XM_047426257.1 → XP_047282213.1  tripartite motif-containing protein 3 isoform X1

    6. XM_047426259.1 → XP_047282215.1  tripartite motif-containing protein 3 isoform X3

      UniProtKB/Swiss-Prot
      B7Z5E6, F5H2Q8, O75382, Q4V9L4, Q9C038, Q9C039

    7. XM_047426262.1 → XP_047282218.1  tripartite motif-containing protein 3 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      6507075..6532930 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367481.1 → XP_054223456.1  tripartite motif-containing protein 3 isoform X4

    2. XM_054367478.1 → XP_054223453.1  tripartite motif-containing protein 3 isoform X3

      UniProtKB/Swiss-Prot
      B7Z5E6, F5H2Q8, O75382, Q4V9L4, Q9C038, Q9C039

    3. XM_054367479.1 → XP_054223454.1  tripartite motif-containing protein 3 isoform X3

      UniProtKB/Swiss-Prot
      B7Z5E6, F5H2Q8, O75382, Q4V9L4, Q9C038, Q9C039

    4. XM_054367477.1 → XP_054223452.1  tripartite motif-containing protein 3 isoform X2

    5. XM_054367476.1 → XP_054223451.1  tripartite motif-containing protein 3 isoform X1

    6. XM_054367480.1 → XP_054223455.1  tripartite motif-containing protein 3 isoform X3

      UniProtKB/Swiss-Prot
      B7Z5E6, F5H2Q8, O75382, Q4V9L4, Q9C038, Q9C039

    7. XM_054367482.1 → XP_054223457.1  tripartite motif-containing protein 3 isoform X5

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_033279.1: Suppressed sequence

      Description
      NM_033279.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75382.2 GenPept UniProtKB/Swiss-Prot:O75382

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