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    RPS21 ribosomal protein S21 [ Homo sapiens (human) ]

    Gene ID: 6227, updated on 10-Dec-2024

    Summary

    Official Symbol
    RPS21provided by HGNC
    Official Full Name
    ribosomal protein S21provided by HGNC
    Primary source
    HGNC:HGNC:10409
    See related
    Ensembl:ENSG00000171858 MIM:180477; AllianceGenome:HGNC:10409
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    S21; HLDF; eS21
    Summary
    Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S21E family of ribosomal proteins. It is located in the cytoplasm. Alternative splice variants that encode different protein isoforms have been described, but their existence has not been verified. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in ovary (RPKM 530.1), bone marrow (RPKM 407.8) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RPS21 in Genome Data Viewer
    Location:
    20q13.33
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (62387103..62388520)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (64183604..64185021)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (60962159..60963576)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372708 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60949451-60950054 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:60950055-60950656 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:60953065-60953666 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60956340-60957020 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18199 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18200 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:60961625-60962316 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:60962317-60963008 Neighboring gene RPS21 divergent transcript Neighboring gene Cdk5 and Abl enzyme substrate 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60967444-60967944 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60967945-60968445 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:60968662-60969186 Neighboring gene uncharacterized LOC105372709 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13112 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18201 Neighboring gene RBBP8 N-terminal like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:60998065-60998856 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:61001435-61002194

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (727 hits/1280 screens)

    EBI GWAS Catalog

    Description
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    located_in cytosol  
    located_in cytosolic ribosome PubMed 
    part_of cytosolic small ribosomal subunit PubMed 
    part_of cytosolic small ribosomal subunit  
    part_of cytosolic small ribosomal subunit PubMed 
    part_of cytosolic small ribosomal subunit PubMed 
    located_in nucleoplasm  
    located_in rough endoplasmic reticulum  
    part_of small ribosomal subunit PubMed 
    located_in synapse  

    General protein information

    Preferred Names
    small ribosomal subunit protein eS21
    Names
    40S ribosomal protein S21
    8.2 kDa differentiation factor
    human leukemia differentiation factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024.4 → NP_001015.1  small ribosomal subunit protein eS21

      See identical proteins and their annotated locations for NP_001015.1

      Status: REVIEWED

      Source sequence(s)
      BM840443, CF124568, L04483
      Consensus CDS
      CCDS13497.1
      UniProtKB/Swiss-Prot
      P35265, P63220
      UniProtKB/TrEMBL
      Q6FGH5
      Related
      ENSP00000345957.3, ENST00000343986.9
      Conserved Domains (1) summary
      pfam01249
      Location:1 → 80
      Ribosomal_S21e; Ribosomal protein S21e

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      62387103..62388520
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      64183604..64185021
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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