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    MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 64780, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MICAL1provided by HGNC
    Official Full Name
    microtubule associated monooxygenase, calponin and LIM domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:20619
    See related
    Ensembl:ENSG00000135596 MIM:607129; AllianceGenome:HGNC:20619
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MICAL; NICAL; MICAL-1
    Summary
    This gene encodes an enzyme that oxidizes methionine residues on actin, thereby promoting depolymerization of actin filaments. This protein interacts with and regulates signalling by NEDD9/CAS-L (neural precursor cell expressed, developmentally down-regulated 9). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
    Expression
    Ubiquitous expression in bone marrow (RPKM 31.4), lymph node (RPKM 25.8) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MICAL1 in Genome Data Viewer
    Location:
    6q21
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (109444062..109465968, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (110622100..110644006, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (109765265..109787171, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17458 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:109703563-109704072 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24923 Neighboring gene Sharpr-MPRA regulatory region 15445 Neighboring gene CD164 molecule Neighboring gene peptidylprolyl isomerase like 6 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:109761883-109762088 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24924 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24925 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17460 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24926 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:109775979-109776487 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24927 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17462 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24928 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24929 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:109801913-109802414 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17463 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17464 Neighboring gene sphingomyelin phosphodiesterase 2 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:109811810-109812520 Neighboring gene zinc finger and BTB domain containing 24 Neighboring gene ZBTB24 divergent transcript Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:109828991-109829516 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:109829517-109830042 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:109834827-109835332 Neighboring gene adenylate kinase 9 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:110000392-110001073 Neighboring gene MPRA-validated peak6018 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24931 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24932 Neighboring gene FIG4 phosphoinositide 5-phosphatase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Extracellular inhibitors, repellents, and semaphorin/plexin/MICAL-mediated actin filament disassembly. Hung RJ, et al. Cytoskeleton (Hoboken), 2011 Aug. PMID 21800438, Free PMC Article
    2. Release of MICAL autoinhibition by semaphorin-plexin signaling promotes interaction with collapsin response mediator protein. Schmidt EF, et al. J Neurosci, 2008 Feb 27. PMID 18305261, Free PMC Article
    3. Structure-function studies of MICAL, the unusual multidomain flavoenzyme involved in actin cytoskeleton dynamics. Vanoni MA. Arch Biochem Biophys, 2017 Oct 15. PMID 28602956
    4. Mutations in MICAL-1cause autosomal-dominant lateral temporal epilepsy. Dazzo E, et al. Ann Neurol, 2018 Mar. PMID 29394500
    5. Investigation of the four cooperative unfolding units existing in the MICAL-1 CH domain. Jin X, et al. Biophys Chem, 2007 Sep. PMID 17662518

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PlexinA1 promotes gastric cancer migration through preventing MICAL1 protein ubiquitin/proteasome-mediated degradation in a Rac1-dependent manner.
      Title: PlexinA1 promotes gastric cancer migration through preventing MICAL1 protein ubiquitin/proteasome-mediated degradation in a Rac1-dependent manner.
    2. High MICAL1 expression correlates with cancer progression and immune infiltration in renal clear cell carcinoma.
      Title: High MICAL1 expression correlates with cancer progression and immune infiltration in renal clear cell carcinoma.
    3. Mical modulates Tau toxicity via cysteine oxidation in vivo.
      Title: Mical modulates Tau toxicity via cysteine oxidation in vivo.
    4. MICAL1 inhibits colorectal cancer cell migration and proliferation by regulating the EGR1/beta-catenin signaling pathway.
      Title: MICAL1 inhibits colorectal cancer cell migration and proliferation by regulating the EGR1/β-catenin signaling pathway.
    5. MICAL1 regulates actin cytoskeleton organization, directional cell migration and the growth of human breast cancer cells as orthotopic xenograft tumours.
      Title: MICAL1 regulates actin cytoskeleton organization, directional cell migration and the growth of human breast cancer cells as orthotopic xenograft tumours.
    6. GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of E-cadherin, MMP14, and CFTR DeltaF508.
      Title: GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of E-cadherin, MMP14, and CFTR ΔF508.
    7. MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII.
      Title: MICAL1 constrains cardiac stress responses and protects against disease by oxidizing CaMKII.
    8. Human MICAL1: Activation by the small GTPase Rab8 and small-angle X-ray scattering studies on the oligomerization state of MICAL1 and its complex with Rab8.
      Title: Human MICAL1: Activation by the small GTPase Rab8 and small-angle X-ray scattering studies on the oligomerization state of MICAL1 and its complex with Rab8.
    9. our results suggest that MICAL1 exhibits its effect on proliferation via maintaining cyclin D expression through ROS-sensitive PI3K/Akt/ERK signalling in breast cancer cells
      Title: MICAL1 facilitates breast cancer cell proliferation via ROS-sensitive ERK/cyclin D pathway.
    10. Two autosomal-dominant lateral temporal epilepsy-causing variants were identified in the MICAL1 gene.
      Title: Mutations in MICAL-1cause autosomal-dominant lateral temporal epilepsy.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • FLJ11937, FLJ21739, DKFZp434B1517

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables F-actin monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NAD(P)H oxidase H2O2-forming activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NADPH oxidase H202-forming activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament depolymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytoskeleton organization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of regulated secretory pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in sulfur oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in actin filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in hippocampal mossy fiber expansion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intermediate filament NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    [F-actin]-monooxygenase MICAL1
    Names
    NEDD9-interacting protein with calponin homology and LIM domains
    [F-actin]-methionine sulfoxide oxidase MICAL1
    molecule interacting with CasL protein 1
    protein-methionine sulfoxide oxidase MICAL1
    NP_001152763.1
    NP_001273542.1
    NP_073602.3

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_042833.1 RefSeqGene

      Range
      15197..26907
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001159291.2 → NP_001152763.1  [F-actin]-monooxygenase MICAL1 isoform 2

      See identical proteins and their annotated locations for NP_001152763.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' exon and thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, and it lacks an alternate in-frame exon in the central coding region, compared to variant 3. The encoded isoform (2, also known as MICAL-1b) is shorter at the N-terminus, compared to isoform 3.
      Source sequence(s)
      AB048948, BC009972, BC042144
      Consensus CDS
      CCDS55047.1
      UniProtKB/TrEMBL
      A0A1S5UZH2
      Related
      ENSP00000351385.3, ENST00000358577.7
      Conserved Domains (5) summary
      cd09358
      Location:611 → 664
      LIM_Mical_like; The LIM domain of Mical (molecule interacting with CasL) like family
      pfam00307
      Location:425 → 521
      CH; Calponin homology (CH) domain
      pfam12130
      Location:841 → 974
      DUF3585; Protein of unknown function (DUF3585)
      pfam13450
      Location:89 → 116
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      pfam16602
      Location:527 → 607
      USP19_linker; Linker region of USP19 deubiquitinase

    2. NM_001286613.2 → NP_001273542.1  [F-actin]-monooxygenase MICAL1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents the longest transrcript and encodes the longest isoform (3).
      Source sequence(s)
      AK296284, AL109947, BC042144
      Consensus CDS
      CCDS69170.1
      UniProtKB/TrEMBL
      A0A1S5UZH2
      Related
      ENSP00000486901.1, ENST00000630715.2
      Conserved Domains (5) summary
      cd09358
      Location:716 → 769
      LIM_Mical_like; The LIM domain of Mical (molecule interacting with CasL) like family
      pfam00307
      Location:530 → 626
      CH; Calponin homology (CH) domain
      pfam12130
      Location:946 → 1079
      DUF3585; Protein of unknown function (DUF3585)
      pfam13450
      Location:108 → 135
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      pfam16602
      Location:632 → 712
      USP19_linker; Linker region of USP19 deubiquitinase

    3. NM_022765.4 → NP_073602.3  [F-actin]-monooxygenase MICAL1 isoform 1

      See identical proteins and their annotated locations for NP_073602.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) contains an alternate 5' exon and thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 3. The encoded isoform (1, also known as MICAL-1a) is shorter at the N-terminus, compared to isoform 3.
      Source sequence(s)
      BC042144
      Consensus CDS
      CCDS5076.1
      UniProtKB/Swiss-Prot
      B7Z3R5, E1P5F0, Q7Z633, Q8IVS9, Q8TDZ2, Q96G47, Q9H6X6, Q9H7I0, Q9HAA1, Q9UFF7
      UniProtKB/TrEMBL
      A0A1S5UZH2
      Related
      ENSP00000351664.3, ENST00000358807.8
      Conserved Domains (5) summary
      cd09358
      Location:697 → 750
      LIM_Mical_like; The LIM domain of Mical (molecule interacting with CasL) like family
      pfam00307
      Location:511 → 607
      CH; Calponin homology (CH) domain
      pfam12130
      Location:927 → 1060
      DUF3585; Protein of unknown function (DUF3585)
      pfam13450
      Location:89 → 116
      NAD_binding_8; NAD(P)-binding Rossmann-like domain
      pfam16602
      Location:613 → 693
      USP19_linker; Linker region of USP19 deubiquitinase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      109444062..109465968 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      110622100..110644006 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TDZ2.2 GenPept UniProtKB/Swiss-Prot:Q8TDZ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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