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    DUS2 dihydrouridine synthase 2 [ Homo sapiens (human) ]

    Gene ID: 54920, updated on 10-Dec-2024

    Summary

    Official Symbol
    DUS2provided by HGNC
    Official Full Name
    dihydrouridine synthase 2provided by HGNC
    Primary source
    HGNC:HGNC:26014
    See related
    Ensembl:ENSG00000167264 MIM:609707; AllianceGenome:HGNC:26014
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SMM1; DUS2L; URLC8
    Summary
    This gene encodes a cytoplasmic protein that catalyzes the conversion of uridine residues to dihydrouridine in the D-loop of tRNA. The resulting modified bases confer enhanced regional flexibility to tRNA. The encoded protein may increase the rate of translation by inhibiting an interferon-induced protein kinase. This gene has been implicated in pulmonary carcinogenesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]
    Expression
    Broad expression in testis (RPKM 12.7), lymph node (RPKM 5.7) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See DUS2 in Genome Data Viewer
    Location:
    16q22.1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (68023284..68079320)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (73819064..73875073)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (68057187..68113223)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:68055836-68056586 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:68056587-68057337 Neighboring gene RNA, U6 small nuclear 359, pseudogene Neighboring gene DEAD-box helicase 28 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:68078446-68078635 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11005 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7638 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7639 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11006 Neighboring gene Sharpr-MPRA regulatory region 7518 Neighboring gene nuclear factor of activated T cells 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7640 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:68197467-68198334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:68221558-68222058 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene ribosomal protein S12 pseudogene 27

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: NFATC3

    Clone Names

    • FLJ20399

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables FMN binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables NADPH binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables tRNA dihydrouridine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables tRNA dihydrouridine synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables tRNA-dihydrouridine20 synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in antiviral innate immune response IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in tRNA dihydrouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tRNA dihydrouridine synthesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HTP PubMed 

    General protein information

    Preferred Names
    tRNA-dihydrouridine(20) synthase [NAD(P)+]-like
    Names
    SMM1 homolog
    dihydrouridine synthase 2-like, SMM1 homolog
    tRNA-dihydrouridine(20) synthase (NAD(P)(+))
    up-regulated in lung cancer protein 8
    NP_001258691.1
    NP_001258692.1
    NP_060273.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271762.2NP_001258691.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform 1

      See identical proteins and their annotated locations for NP_001258691.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC130462, AK000406, BC006527
      Consensus CDS
      CCDS10859.1
      UniProtKB/Swiss-Prot
      A8K3G3, Q4H4D9, Q9NX74
      UniProtKB/TrEMBL
      B4DKP8
      Related
      ENSP00000351769.6, ENST00000358896.10
      Conserved Domains (2) summary
      cd00048
      Location:369433
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      cd02801
      Location:13252
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    2. NM_001271763.2NP_001258692.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two alternate exons, resulting in the loss of an in-frame segment in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC130462, AK000406, AK296663, BC006527
      Consensus CDS
      CCDS61970.1
      UniProtKB/TrEMBL
      B4DKP8, E7EUN9
      Related
      ENSP00000409498.1, ENST00000432752.5
      Conserved Domains (3) summary
      COG0042
      Location:10279
      DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]
      cd00048
      Location:334398
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      cd02801
      Location:13217
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...
    3. NM_017803.5NP_060273.1  tRNA-dihydrouridine(20) synthase [NAD(P)+]-like isoform 1

      See identical proteins and their annotated locations for NP_060273.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC130462, AK000406, BC006527
      Consensus CDS
      CCDS10859.1
      UniProtKB/Swiss-Prot
      A8K3G3, Q4H4D9, Q9NX74
      UniProtKB/TrEMBL
      B4DKP8
      Related
      ENSP00000455229.1, ENST00000565263.6
      Conserved Domains (2) summary
      cd00048
      Location:369433
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      cd02801
      Location:13252
      DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      68023284..68079320
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      73819064..73875073
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)