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    GPR63 G protein-coupled receptor 63 [ Homo sapiens (human) ]

    Gene ID: 81491, updated on 10-Dec-2024

    Summary

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    Official Symbol
    GPR63provided by HGNC
    Official Full Name
    G protein-coupled receptor 63provided by HGNC
    Primary source
    HGNC:HGNC:13302
    See related
    Ensembl:ENSG00000112218 MIM:606915; AllianceGenome:HGNC:13302
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PSP24B; PSP24(beta)
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in cytosol; nucleoplasm; and plasma membrane. Part of receptor complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 1.6), brain (RPKM 1.0) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GPR63 in Genome Data Viewer
    Location:
    6q16.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (96794125..96837477, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (97965926..98009403, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (97242001..97285353, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377908 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:97210120-97210694 Neighboring gene eukaryotic translation elongation factor 1 gamma pseudogene 6 Neighboring gene MPRA-validated peak5968 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17408 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24845 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24846 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 4 Neighboring gene RNA, 7SL, cytoplasmic 509, pseudogene Neighboring gene kelch like family member 32

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Endothelial cell-derived S1P promotes migration and stemness by binding with GPR63 in colorectal cancer. Zeng S, et al. Pathol Res Pract, 2022 Dec. PMID 36371997
    2. Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63. Niedernberg A, et al. Cell Signal, 2003 Apr. PMID 12618218
    3. Mammalian PSP24s (alpha and beta isoforms) are not responsive to lysophosphatidic acid in mammalian expression systems. Kawasawa Y, et al. Biochem Biophys Res Commun, 2000 Oct 5. PMID 11027575
    4. Identification of four novel human G protein-coupled receptors expressed in the brain. Lee DK, et al. Brain Res Mol Brain Res, 2001 Jan 31. PMID 11165367
    5. Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45. Kawasawa Y, et al. Biochem Biophys Res Commun, 2000 Oct 5. PMID 11027574

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Endothelial cell-derived S1P promotes migration and stemness by binding with GPR63 in colorectal cancer.
      Title: Endothelial cell-derived S1P promotes migration and stemness by binding with GPR63 in colorectal cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 63
    Names
    PSP24-2
    PSP24-beta
    brain expressed G-protein-coupled receptor PSP24 beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001143957.3 → NP_001137429.1  probable G-protein coupled receptor 63

      See identical proteins and their annotated locations for NP_001137429.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AI208851, AK289839, AK313535, AL033379, DA242987, DB119067
      Consensus CDS
      CCDS5036.1
      UniProtKB/Swiss-Prot
      Q9BZJ6, Q9UJH3
      UniProtKB/TrEMBL
      A8K1C4, Q6NWR8, Q6NWR9
      Conserved Domains (1) summary
      cd15404
      Location:82 → 382
      7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_030784.4 → NP_110411.1  probable G-protein coupled receptor 63

      See identical proteins and their annotated locations for NP_110411.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AI208851, AK289839, AK313535, AL033379, DA242987
      Consensus CDS
      CCDS5036.1
      UniProtKB/Swiss-Prot
      Q9BZJ6, Q9UJH3
      UniProtKB/TrEMBL
      A8K1C4, Q6NWR8, Q6NWR9
      Related
      ENSP00000229955.2, ENST00000229955.4
      Conserved Domains (1) summary
      cd15404
      Location:82 → 382
      7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      96794125..96837477 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011536155.2 → XP_011534457.1  probable G-protein coupled receptor 63 isoform X1

      See identical proteins and their annotated locations for XP_011534457.1

      UniProtKB/Swiss-Prot
      Q9BZJ6, Q9UJH3
      UniProtKB/TrEMBL
      A8K1C4, Q6NWR8, Q6NWR9
      Conserved Domains (1) summary
      cd15404
      Location:82 → 382
      7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_011536159.2 → XP_011534461.1  probable G-protein coupled receptor 63 isoform X1

      See identical proteins and their annotated locations for XP_011534461.1

      UniProtKB/Swiss-Prot
      Q9BZJ6, Q9UJH3
      UniProtKB/TrEMBL
      A8K1C4, Q6NWR8, Q6NWR9
      Conserved Domains (1) summary
      cd15404
      Location:82 → 382
      7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. XM_011536157.3 → XP_011534459.1  probable G-protein coupled receptor 63 isoform X1

      See identical proteins and their annotated locations for XP_011534459.1

      UniProtKB/Swiss-Prot
      Q9BZJ6, Q9UJH3
      UniProtKB/TrEMBL
      A8K1C4, Q6NWR8, Q6NWR9
      Conserved Domains (1) summary
      cd15404
      Location:82 → 382
      7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors

    4. XM_017011334.2 → XP_016866823.1  probable G-protein coupled receptor 63 isoform X1

      UniProtKB/Swiss-Prot
      Q9BZJ6, Q9UJH3
      UniProtKB/TrEMBL
      A8K1C4, Q6NWR8, Q6NWR9
      Conserved Domains (1) summary
      cd15404
      Location:82 → 382
      7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors

    5. XM_011536154.3 → XP_011534456.1  probable G-protein coupled receptor 63 isoform X1

      See identical proteins and their annotated locations for XP_011534456.1

      UniProtKB/Swiss-Prot
      Q9BZJ6, Q9UJH3
      UniProtKB/TrEMBL
      A8K1C4, Q6NWR8, Q6NWR9
      Conserved Domains (1) summary
      cd15404
      Location:82 → 382
      7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors

    6. XM_011536153.2 → XP_011534455.1  probable G-protein coupled receptor 63 isoform X1

      See identical proteins and their annotated locations for XP_011534455.1

      UniProtKB/Swiss-Prot
      Q9BZJ6, Q9UJH3
      UniProtKB/TrEMBL
      A8K1C4, Q6NWR8, Q6NWR9
      Conserved Domains (1) summary
      cd15404
      Location:82 → 382
      7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors

    7. XM_006715570.5 → XP_006715633.1  probable G-protein coupled receptor 63 isoform X1

      See identical proteins and their annotated locations for XP_006715633.1

      UniProtKB/Swiss-Prot
      Q9BZJ6, Q9UJH3
      UniProtKB/TrEMBL
      A8K1C4, Q6NWR8, Q6NWR9
      Conserved Domains (1) summary
      cd15404
      Location:82 → 382
      7tmA_GPR63; G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      97965926..98009403 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356483.1 → XP_054212458.1  probable G-protein coupled receptor 63 isoform X1

      UniProtKB/Swiss-Prot
      Q9BZJ6, Q9UJH3
      UniProtKB/TrEMBL
      A8K1C4, Q6NWR8, Q6NWR9

    2. XM_054356484.1 → XP_054212459.1  probable G-protein coupled receptor 63 isoform X1

      UniProtKB/Swiss-Prot
      Q9BZJ6, Q9UJH3
      UniProtKB/TrEMBL
      A8K1C4, Q6NWR8, Q6NWR9

    3. XM_054356482.1 → XP_054212457.1  probable G-protein coupled receptor 63 isoform X1

      UniProtKB/Swiss-Prot
      Q9BZJ6, Q9UJH3
      UniProtKB/TrEMBL
      A8K1C4, Q6NWR8, Q6NWR9

    4. XM_054356485.1 → XP_054212460.1  probable G-protein coupled receptor 63 isoform X1

      UniProtKB/Swiss-Prot
      Q9BZJ6, Q9UJH3
      UniProtKB/TrEMBL
      A8K1C4, Q6NWR8, Q6NWR9

    5. XM_054356486.1 → XP_054212461.1  probable G-protein coupled receptor 63 isoform X1

      UniProtKB/Swiss-Prot
      Q9BZJ6, Q9UJH3
      UniProtKB/TrEMBL
      A8K1C4, Q6NWR8, Q6NWR9

    6. XM_054356487.1 → XP_054212462.1  probable G-protein coupled receptor 63 isoform X1

      UniProtKB/Swiss-Prot
      Q9BZJ6, Q9UJH3
      UniProtKB/TrEMBL
      A8K1C4, Q6NWR8, Q6NWR9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BZJ6.2 GenPept UniProtKB/Swiss-Prot:Q9BZJ6

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