U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    MARK1 microtubule affinity regulating kinase 1 [ Homo sapiens (human) ]

    Gene ID: 4139, updated on 10-Dec-2024

    Summary

    Official Symbol
    MARK1provided by HGNC
    Official Full Name
    microtubule affinity regulating kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:6896
    See related
    Ensembl:ENSG00000116141 MIM:606511; AllianceGenome:HGNC:6896
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MARK; Par1c; Par-1c
    Summary
    Enables several functions, including ATP binding activity; phospholipid binding activity; and protein kinase activity. Involved in intracellular signal transduction; negative regulation of epithelial to mesenchymal transition; and protein phosphorylation. Located in cytoplasm; dendrite; and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in brain (RPKM 4.9), testis (RPKM 3.5) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See MARK1 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (220528136..220664461)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (219767527..219904166)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (220701478..220837803)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372928 Neighboring gene long intergenic non-protein coding RNA 2779 Neighboring gene Sharpr-MPRA regulatory region 1437 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1825 Neighboring gene RNA, 7SL, cytoplasmic 464, pseudogene Neighboring gene histone deacetylase 1 pseudogene 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:220856220-220856720 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1826 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:220869747-220870946 Neighboring gene chromosome 1 open reading frame 115 Neighboring gene uncharacterized LOC124904516 Neighboring gene mitochondrial amidoxime reducing component 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (15 hits/1302 screens)

    EBI GWAS Catalog

    Description
    Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men.
    EBI GWAS Catalog
    Genome-wide association study in bipolar patients stratified by co-morbidity.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of MAP/microtubule affinity-regulating kinase 1 (MARK1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • KIAA1477, MGC126512, MGC126513

    Gene Ontology Provided by GOA

    Items 1 - 25 of 34
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding PubMed 
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables magnesium ion binding PubMed 
    enables phosphatidic acid binding PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding PubMed 
    enables phosphatidylserine binding PubMed 
    enables protein binding PubMed 
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity PubMed 
    enables ribosomal protein S6 kinase activity  
    enables tau protein binding PubMed 
    enables tau-protein kinase activity PubMed 
    enables tau-protein kinase activity  
    enables tau-protein kinase activity PubMed 
    Items 1 - 25 of 34
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway  
    involved_in chromatin remodeling  
    involved_in cytoskeleton organization  
    involved_in establishment of mitochondrion localization  
    involved_in intracellular signal transduction  
    involved_in intracellular signal transduction PubMed 
    involved_in microtubule cytoskeleton organization PubMed 
    involved_in negative regulation of epithelial to mesenchymal transition PubMed 
    acts_upstream_of negative regulation of gene expression PubMed 
    involved_in neuron migration  
    acts_upstream_of positive regulation of gene expression PubMed 
    involved_in protein phosphorylation PubMed 
    involved_in protein phosphorylation PubMed 
    involved_in regulation of dendrite development  
    involved_in regulation of neuron projection development  
    involved_in regulation of postsynapse assembly  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytoskeleton  
    located_in dendrite PubMed 
    located_in glutamatergic synapse  
    located_in microtubule cytoskeleton PubMed 
    located_in plasma membrane PubMed 
    located_in postsynapse  

    General protein information

    Preferred Names
    serine/threonine-protein kinase MARK1
    Names
    MAP/microtubule affinity-regulating kinase 1
    PAR1 homolog c
    NP_001273053.1
    NP_001273055.1
    NP_001273057.1
    NP_001273058.1
    NP_061120.3
    XP_005273191.1
    XP_006711389.1
    XP_011507863.1
    XP_011507864.1
    XP_016856794.1
    XP_024302858.1
    XP_047276800.1
    XP_054192613.1
    XP_054192614.1
    XP_054192615.1
    XP_054192616.1
    XP_054192617.1
    XP_054192618.1
    XP_054192619.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286124.2 → NP_001273053.1  serine/threonine-protein kinase MARK1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC096640, AK314614, AL592406, BC068608, CA412112
      Consensus CDS
      CCDS73033.1
      UniProtKB/TrEMBL
      A0A087X0I6, X5DNR8
      Related
      ENSP00000483424.1, ENST00000611084.4
      Conserved Domains (4) summary
      cd12196
      Location:697 → 794
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:60 → 311
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14405
      Location:331 → 371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59 → 311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    2. NM_001286126.2 → NP_001273055.1  serine/threonine-protein kinase MARK1 isoform 3

      See identical proteins and their annotated locations for NP_001273055.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site and lacks an exon in the 3' coding region but maintains the reading frame, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AC096640, AK295506, AL592406, BC068608, CA412112
      Consensus CDS
      CCDS73034.1
      UniProtKB/TrEMBL
      B4DIB3, X5DNR8
      Related
      ENSP00000386017.2, ENST00000402574.5
      Conserved Domains (4) summary
      cd12196
      Location:681 → 778
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:60 → 311
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14405
      Location:331 → 371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59 → 311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    3. NM_001286128.2 → NP_001273057.1  serine/threonine-protein kinase MARK1 isoform 4

      See identical proteins and their annotated locations for NP_001273057.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 4, which is shorter than isoform 1.
      Source sequence(s)
      AB040910, AC096640, AL592406, BC068608, CA412112
      Consensus CDS
      CCDS65789.1
      UniProtKB/TrEMBL
      A0A7I2V550
      Related
      ENSP00000355885.4, ENST00000366918.8
      Conserved Domains (4) summary
      cd12196
      Location:659 → 756
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:60 → 289
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14405
      Location:309 → 349
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cl21453
      Location:59 → 289
      PKc_like; Protein Kinases, catalytic domain
    4. NM_001286129.2 → NP_001273058.1  serine/threonine-protein kinase MARK1 isoform 5

      See identical proteins and their annotated locations for NP_001273058.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 3' UTR and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 5) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC096640, BC068608
      UniProtKB/TrEMBL
      A0A7I2V4P8
      Conserved Domains (1) summary
      cl21453
      Location:59 → 105
      PKc_like; Protein Kinases, catalytic domain
    5. NM_018650.5 → NP_061120.3  serine/threonine-protein kinase MARK1 isoform 2

      See identical proteins and their annotated locations for NP_061120.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC096640, AL592406, BC068608, BC113869, CA412112
      Consensus CDS
      CCDS31029.2
      UniProtKB/Swiss-Prot
      D3DTB0, D3DTB1, Q2HIY1, Q5VTF9, Q5VTG0, Q96SW9, Q9P0L2, Q9P251
      UniProtKB/TrEMBL
      X5DNR8
      Related
      ENSP00000355884.5, ENST00000366917.6
      Conserved Domains (4) summary
      cd12196
      Location:696 → 793
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:60 → 311
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14405
      Location:331 → 371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59 → 311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      220528136..220664461
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017001305.3 → XP_016856794.1  serine/threonine-protein kinase MARK1 isoform X5

      UniProtKB/TrEMBL
      A0A7I2YQC1
      Related
      ENSP00000503257.1, ENST00000678435.1
      Conserved Domains (4) summary
      cd12196
      Location:587 → 684
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:1 → 201
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14405
      Location:221 → 261
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cl21453
      Location:1 → 201
      PKc_like; Protein Kinases, catalytic domain
    2. XM_005273134.6 → XP_005273191.1  serine/threonine-protein kinase MARK1 isoform X3

      See identical proteins and their annotated locations for XP_005273191.1

      UniProtKB/TrEMBL
      X5D2M4, X5DNR8
      Conserved Domains (4) summary
      cd12196
      Location:682 → 779
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:60 → 311
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14405
      Location:331 → 371
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:59 → 311
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    3. XM_024447090.2 → XP_024302858.1  serine/threonine-protein kinase MARK1 isoform X6

      Conserved Domains (1) summary
      cd14072
      Location:59 → 303
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    4. XM_011509561.4 → XP_011507863.1  serine/threonine-protein kinase MARK1 isoform X1

      UniProtKB/TrEMBL
      X5DNR8
      Conserved Domains (4) summary
      cd12196
      Location:689 → 786
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:52 → 303
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14405
      Location:323 → 363
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cd14072
      Location:51 → 303
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    5. XM_047420844.1 → XP_047276800.1  serine/threonine-protein kinase MARK1 isoform X2

      UniProtKB/TrEMBL
      X5DNR8
    6. XM_006711326.5 → XP_006711389.1  serine/threonine-protein kinase MARK1 isoform X4

      UniProtKB/TrEMBL
      A0A7I2YQC1
      Conserved Domains (4) summary
      cd12196
      Location:609 → 706
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:15 → 223
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14405
      Location:243 → 283
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cl21453
      Location:10 → 223
      PKc_like; Protein Kinases, catalytic domain
    7. XM_011509562.4 → XP_011507864.1  serine/threonine-protein kinase MARK1 isoform X5

      UniProtKB/TrEMBL
      A0A7I2YQC1
      Conserved Domains (4) summary
      cd12196
      Location:587 → 684
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:1 → 201
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14405
      Location:221 → 261
      UBA_MARK1; UBA domain found in serine/threonine-protein kinase MARK1 and similar proteins
      cl21453
      Location:1 → 201
      PKc_like; Protein Kinases, catalytic domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      219767527..219904166
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336642.1 → XP_054192617.1  serine/threonine-protein kinase MARK1 isoform X5

      UniProtKB/TrEMBL
      A0A7I2YQC1
    2. XM_054336640.1 → XP_054192615.1  serine/threonine-protein kinase MARK1 isoform X3

      UniProtKB/TrEMBL
      X5D2M4, X5DNR8
    3. XM_054336644.1 → XP_054192619.1  serine/threonine-protein kinase MARK1 isoform X6

    4. XM_054336638.1 → XP_054192613.1  serine/threonine-protein kinase MARK1 isoform X1

      UniProtKB/TrEMBL
      X5DNR8
    5. XM_054336639.1 → XP_054192614.1  serine/threonine-protein kinase MARK1 isoform X2

      UniProtKB/TrEMBL
      X5DNR8
    6. XM_054336641.1 → XP_054192616.1  serine/threonine-protein kinase MARK1 isoform X4

      UniProtKB/TrEMBL
      A0A7I2YQC1
    7. XM_054336643.1 → XP_054192618.1  serine/threonine-protein kinase MARK1 isoform X5

      UniProtKB/TrEMBL
      A0A7I2YQC1
    External link. Please review our privacy policy.