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    GLK1 glucokinase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850317, updated on 9-Dec-2024

    Summary

    Official Symbol
    GLK1
    Official Full Name
    glucokinase
    Primary source
    SGD:S000000545
    Locus tag
    YCL040W
    See related
    AllianceGenome:SGD:S000000545; FungiDB:YCL040W; VEuPathDB:YCL040W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HOR3
    Summary
    Enables glucokinase activity. Involved in D-glucose import; glycolytic process; and hexose metabolic process. Located in cytosol and plasma membrane. Used to study hyperglycemia; hyperinsulinemic hypoglycemia; maturity-onset diabetes of the young; and neonatal diabetes. Human ortholog(s) of this gene implicated in artery disease (multiple); glucose metabolism disease (multiple); obesity; and retinitis pigmentosa. Orthologous to several human genes including GCK (glucokinase); HK2 (hexokinase 2); and HK3 (hexokinase 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See GLK1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (50838..52340)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Mgr1p Neighboring gene protein disulfide isomerase PDI1 Neighboring gene uncharacterized protein Neighboring gene glucose-induced degradation complex subunit GID7 Neighboring gene Atg22p

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables D-glucose binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables fructokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glucokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glucokinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables glucokinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables glucokinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables hexokinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in D-glucose import IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in carbohydrate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glucose 6-phosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glycolytic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hexose metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular glucose homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in intracellular glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mannose metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane HDA PubMed 

    General protein information

    Preferred Names
    glucokinase
    NP_009890.1
    • Glucokinase; catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources; GLK1 has a paralog, EMI2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      50838..52340
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178685.1NP_009890.1  TPA: glucokinase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009890.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQX5, P17709
      UniProtKB/TrEMBL
      A6ZTF0, B3LU42, C7GSZ7, C8Z449, N1P652
      Conserved Domains (1) summary
      COG5026
      Location:1500
      COG5026; Hexokinase [Carbohydrate transport and metabolism]