Uba2 ubiquitin-like modifier activating enzyme 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Uba2provided by MGI
Official Full Name: ubiquitin-like modifier activating enzyme 2provided by MGI
Primary source: MGI:MGI:1858313
See related: Ensembl:ENSMUSG00000052997 AllianceGenome:MGI:1858313
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Arx; Sae2; UBA1; Ubl1a2; Uble1b
Summary: Enables SUMO activating enzyme activity. Predicted to be involved in positive regulation of protein sumoylation and protein sumoylation. Part of SUMO activating enzyme complex. Is expressed in branchial arch; embryo; limb; and neural fold. Orthologous to human UBA2 (ubiquitin like modifier activating enzyme 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 54.7), CNS E14 (RPKM 34.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B1; 7 19.41 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (33840121..33868014, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (34140697..34168590, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables SUMO activating enzyme activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to SUMO activating enzyme activity	ISO Inferred from Sequence Orthology more info
enables SUMO activating enzyme activity	ISO Inferred from Sequence Orthology more info
enables SUMO activating enzyme activity	ISS Inferred from Sequence or Structural Similarity more info
enables SUMO binding	IEA Inferred from Electronic Annotation more info
enables SUMO binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables small protein activating enzyme binding	IEA Inferred from Electronic Annotation more info
enables small protein activating enzyme binding	ISO Inferred from Sequence Orthology more info
enables transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-like protein conjugating enzyme binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin-like protein conjugating enzyme binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of protein sumoylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein sumoylation	ISO Inferred from Sequence Orthology more info
involved_in protein sumoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein sumoylation	IEA Inferred from Electronic Annotation more info
involved_in protein sumoylation	ISO Inferred from Sequence Orthology more info
involved_in protein sumoylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of SUMO activating enzyme complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SUMO activating enzyme complex	IDA Inferred from Direct Assay more info	PubMed
part_of SUMO activating enzyme complex	ISO Inferred from Sequence Orthology more info
part_of SUMO activating enzyme complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: SUMO-activating enzyme subunit 2

Names: SUMO1 activating enzyme subunit 2; Sumo-1 activating enzyme subunit 2; anthracycline-associated resistance ARX; ubiquitin-like 1 (sentrin) activating enzyme E1B; ubiquitin-like 1 (sentrin) activating enzyme subunit 2; ubiquitin-like 1-activating enzyme E1B

NP_001405401.1

EC 6.3.2.-

NP_001405402.1

EC 6.3.2.-

NP_001405403.1

EC 6.3.2.-

NP_001405405.1

EC 6.3.2.-

NP_057891.1

EC 6.3.2.-

XP_017177837.1

EC 6.3.2.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418472.1 → NP_001405401.1 SUMO-activating enzyme subunit 2 isoform 2

Status: VALIDATED

Source sequence(s)

BX537302
NM_001418473.1 → NP_001405402.1 SUMO-activating enzyme subunit 2 isoform 3

Status: VALIDATED

Source sequence(s)

BX537302
NM_001418474.1 → NP_001405403.1 SUMO-activating enzyme subunit 2 isoform 4

Status: VALIDATED

Source sequence(s)

BX537302
NM_001418476.1 → NP_001405405.1 SUMO-activating enzyme subunit 2 isoform 5

Status: VALIDATED

Source sequence(s)

BX537302
NM_016682.3 → NP_057891.1 SUMO-activating enzyme subunit 2 isoform 1

See identical proteins and their annotated locations for NP_057891.1

Status: VALIDATED

Source sequence(s)

BX537302

Consensus CDS

CCDS21136.1

UniProtKB/Swiss-Prot

Q3TQN3, Q3U819, Q3U9J5, Q8BVX9, Q9Z1F9

Related

ENSMUSP00000099807.5, ENSMUST00000102746.11

Conserved Domains (4) summary

cd01489
Location:19 → 442

Uba2_SUMO; Ubiquitin activating enzyme (E1) subunit UBA2. UBA2 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...

pfam00899
Location:9 → 175

ThiF; ThiF family

pfam14732
Location:450 → 536

UAE_UbL; Ubiquitin/SUMO-activating enzyme ubiquitin-like domain

pfam16195
Location:547 → 633

UBA2_C; SUMO-activating enzyme subunit 2 C-terminus

RNA

NR_184752.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

BX537302
NR_184753.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

BX537302
NR_184754.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

BX537302

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

33840121..33868014 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017322348.3 → XP_017177837.1 SUMO-activating enzyme subunit 2 isoform X1

Conserved Domains (3) summary

cd01489
Location:19 → 442

Uba2_SUMO; Ubiquitin activating enzyme (E1) subunit UBA2. UBA2 is part of the heterodimeric activating enzyme (E1), specific for the SUMO family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...

pfam14732
Location:450 → 536

UAE_UbL; Ubiquitin/SUMO-activating enzyme ubiquitin-like domain

pfam16195
Location:549 → 578

UBA2_C; SUMO-activating enzyme subunit 2 C-terminus