Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hsd17b10provided by MGI
Official Full Name: hydroxysteroid (17-beta) dehydrogenase 10provided by MGI
Primary source: MGI:MGI:1333871
See related: Ensembl:ENSMUSG00000025260 AllianceGenome:MGI:1333871
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ads9; ERAB; MHBD; Hadh2; 17bHSD10
Summary: Predicted to enable several functions, including amyloid-beta binding activity; nuclear estrogen receptor binding activity; and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in several processes, including carboxylic acid catabolic process; mitochondrial tRNA processing; and steroid metabolic process. Located in endoplasmic reticulum and mitochondrial nucleoid. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in pheochromocytoma and syndromic X-linked intellectual disability type 10. Orthologous to human HSD17B10 (hydroxysteroid 17-beta dehydrogenase 10). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in kidney adult (RPKM 56.1), liver adult (RPKM 49.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: X F3; X 68.46 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (150784892..150787438)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (152001896..152004442)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Involvement of Type 10 17beta-Hydroxysteroid Dehydrogenase in the Pathogenesis of Infantile Neurodegeneration and Alzheimer's Disease.
Title: Involvement of Type 10 17β-Hydroxysteroid Dehydrogenase in the Pathogenesis of Infantile Neurodegeneration and Alzheimer's Disease.
The Mitochondrial Enzyme 17betaHSD10 Modulates Ischemic and Amyloid-beta-Induced Stress in Primary Mouse Astrocytes.
Title: The Mitochondrial Enzyme 17βHSD10 Modulates Ischemic and Amyloid-β-Induced Stress in Primary Mouse Astrocytes.
Data show that donor engraftment is necessary for BMT-mediated reduction in age-related amyloid plaque formation in prostaglandin E2 receptor subtype 2-null mice, and that this is accompanied by reduced neurotoxic forms of amyloid peptides.
Title: Suppressed accumulation of cerebral amyloid {beta} peptides in aged transgenic Alzheimer's disease mice by transplantation with wild-type or prostaglandin E2 receptor subtype 2-null bone marrow.
that 17beta-HSD-10 is a major product of both fetal and adult-type Leydig cells.
Title: Differentiation-dependent expression of 17beta-hydroxysteroid dehydrogenase, type 10, in the rodent testis: effect of aging in Leydig cells.
ABAD enhances Abeta-induced cell stress via mitochondrial dysfunction.Amyloid-beta peptide (Abeta) binding alcohol dehydrogenase (ABAD), an enzyme present in neuronal mitochondria, is a cofactor facilitating Abeta-induced cell stress.
Title: ABAD enhances Abeta-induced cell stress via mitochondrial dysfunction.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 17-beta-hydroxysteroid dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables 17-beta-hydroxysteroid dehydrogenase (NAD+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 3-hydroxyacyl-CoA dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables 3-hydroxyacyl-CoA dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables NAD binding	ISO Inferred from Sequence Orthology more info
enables acetoacetyl-CoA reductase activity	ISO Inferred from Sequence Orthology more info
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables androstan-3-alpha,17-beta-diol dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables chenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables cholate 7-alpha-dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables cholate 7-alpha-dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity	IBA Inferred from Biological aspect of Ancestor more info
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity	IEA Inferred from Electronic Annotation more info
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables isoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables steroid binding	ISO Inferred from Sequence Orthology more info
enables tRNA binding	ISO Inferred from Sequence Orthology more info
enables tRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables testosterone dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables testosterone dehydrogenase (NAD+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables testosterone dehydrogenase [NAD(P)+] activity	ISO Inferred from Sequence Orthology more info
enables testosterone dehydrogenase [NAD(P)+] activity	ISS Inferred from Sequence or Structural Similarity more info
enables ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables ursodeoxycholate 7-beta-dehydrogenase (NAD+) activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in C21-steroid hormone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in C21-steroid hormone metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in androgen metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in androgen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in androgen metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in bile acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in bile acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in bile acid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in brexanolone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in brexanolone metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in estrogen metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in estrogen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in estrogen metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid beta-oxidation	IEA Inferred from Electronic Annotation more info
involved_in fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
involved_in fatty acid beta-oxidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in isoleucine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in isoleucine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in isoleucine catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial tRNA 3'-end processing	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial tRNA 3'-end processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial tRNA 5'-end processing	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial tRNA 5'-end processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial tRNA methylation	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial tRNA methylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	HDA more info	PubMed
located_in mitochondrial nucleoid	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial nucleoid	ISO Inferred from Sequence Orthology more info
part_of mitochondrial ribonuclease P complex	ISO Inferred from Sequence Orthology more info
part_of mitochondrial ribonuclease P complex	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of tRNA methyltransferase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 3-hydroxyacyl-CoA dehydrogenase type-2

Names: 17-beta-HSD 10; 17-beta-estradiol 17-dehydrogenase; 17-beta-hydroxysteroid dehydrogenase 10; 2-methyl-3-hydroxybutyryl-CoA dehydrogenase; 3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+)); 3-hydroxy-2-methylbutyryl-CoA dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase type II; 3alpha(or 20beta)-hydroxysteroid dehydrogenase; 7-alpha-hydroxysteroid dehydrogenase; endoplasmic reticulum-associated amyloid beta-peptide-binding protein; hydroxyacyl-Coenzyme A dehydrogenase, type II; mitochondrial RNase P protein 2; mitochondrial ribonuclease P protein 2; short chain dehydrogenase/reductase family 5C member 1; short-chain type dehydrogenase/reductase XH98G2; type II HADH

NP_058043.3

EC 1.1.1.159

EC 1.1.1.178

EC 1.1.1.239

EC 1.1.1.35

EC 1.1.1.53

EC 1.1.1.62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016763.2 → NP_058043.3 3-hydroxyacyl-CoA dehydrogenase type-2

Status: VALIDATED

Source sequence(s)

BC027517

Consensus CDS

CCDS30471.1

UniProtKB/TrEMBL

Q99N15, Q9CYT3

Related

ENSMUSP00000026289.4, ENSMUST00000026289.10

Conserved Domains (2) summary

cd05371
Location:9 → 261

HSD10-like_SDR_c; 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs

PRK05557
Location:7 → 260

fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated