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    Numbl numb-like [ Mus musculus (house mouse) ]

    Gene ID: 18223, updated on 9-Dec-2024

    Summary

    Official Symbol
    Numblprovided by MGI
    Official Full Name
    numb-likeprovided by MGI
    Primary source
    MGI:MGI:894702
    See related
    Ensembl:ENSMUSG00000063160 AllianceGenome:MGI:894702
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    nbl
    Summary
    Involved in lateral ventricle development; neuroblast division in subventricular zone; and positive regulation of neurogenesis. Acts upstream of or within adherens junction organization and nervous system development. Located in cytoplasm. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system gland; peripheral nervous system ganglion; and sensory organ. Orthologous to human NUMBL (NUMB like endocytic adaptor protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in ovary adult (RPKM 20.9), limb E14.5 (RPKM 20.4) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Numbl in Genome Data Viewer
    Location:
    7 A3; 7 15.86 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (26957884..26981570)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (27258438..27282150)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene actin maturation protease Neighboring gene inositol 1,4,5-trisphosphate 3-kinase C Neighboring gene STARR-positive B cell enhancer ABC_E2229 Neighboring gene coenzyme Q8B Neighboring gene STARR-positive B cell enhancer ABC_E4906 Neighboring gene ribosomal protein L14 pseudogene Neighboring gene STARR-seq mESC enhancer starr_18356 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28101108-28101366 Neighboring gene latent transforming growth factor beta binding protein 4 Neighboring gene STARR-positive B cell enhancer ABC_E4907 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:28117793-28117976 Neighboring gene predicted gene, 30543 Neighboring gene STARR-positive B cell enhancer ABC_E1726 Neighboring gene Sh3kbp1 binding protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acts_upstream_of_or_within adherens junction organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytokine-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lateral ventricle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuroblast division in subventricular zone IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuroblast proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of dendrite morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of postsynapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417032.1NP_001403961.1  numb-like protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC157561
    2. NM_001417033.1NP_001403962.1  numb-like protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC157561
      UniProtKB/TrEMBL
      Q3UH86
    3. NM_010950.3NP_035080.2  numb-like protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157561
      Consensus CDS
      CCDS21016.1
      UniProtKB/Swiss-Prot
      O08919, Q4QQQ2, Q6NVG8
      Related
      ENSMUSP00000078245.7, ENSMUST00000079258.7
      Conserved Domains (2) summary
      cd01268
      Location:64198
      PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
      pfam06311
      Location:287371
      NumbF; NUMB domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      26957884..26981570
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250452.2XP_011248754.1  numb-like protein isoform X1

      Conserved Domains (3) summary
      PHA03247
      Location:259498
      PHA03247; large tegument protein UL36; Provisional
      cd01268
      Location:64198
      PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
      pfam06311
      Location:289371
      NumbF; NUMB domain
    2. XM_030242207.2XP_030098067.1  numb-like protein isoform X3

      UniProtKB/TrEMBL
      Q3UH86
      Conserved Domains (3) summary
      PHA03247
      Location:218549
      PHA03247; large tegument protein UL36; Provisional
      cd01268
      Location:23157
      PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
      pfam06311
      Location:248330
      NumbF; NUMB domain
    3. XM_006539615.3XP_006539678.1  numb-like protein isoform X2

      Conserved Domains (3) summary
      PHA03247
      Location:263594
      PHA03247; large tegument protein UL36; Provisional
      cd01268
      Location:68202
      PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
      pfam06311
      Location:293375
      NumbF; NUMB domain