Cyp2d34 cytochrome P450, family 2, subfamily d, polypeptide 34 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyp2d34provided by MGI
Official Full Name: cytochrome P450, family 2, subfamily d, polypeptide 34provided by MGI
Primary source: MGI:MGI:2385022
See related: Ensembl:ENSMUSG00000094559 AllianceGenome:MGI:2385022
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable anandamide epoxidase activity; aromatase activity; and heme binding activity. Predicted to be involved in arachidonate metabolic process and xenobiotic metabolic process. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hepatitis; extrapyramidal and movement disease; head and neck squamous cell carcinoma; leukemia (multiple); and major depressive disorder. Orthologous to human CYP2D6 (cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)) and CYP2D7 (cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward colon adult (RPKM 133.9) See more
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Genomic context

Location:: 15 E1; 15 38.66 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (82500164..82505157, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (82615963..82620956, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

Cyp2d9 (e-PCR), detects polymorphism
- UniSTS:462996

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables anandamide 11,12 epoxidase activity	ISO Inferred from Sequence Orthology more info
enables anandamide 14,15 epoxidase activity	ISO Inferred from Sequence Orthology more info
enables anandamide 8,9 epoxidase activity	ISO Inferred from Sequence Orthology more info
enables aromatase activity	ISO Inferred from Sequence Orthology more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in arachidonate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytochrome P450, family 2, subfamily d, polypeptide 34

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145474.2 → NP_663449.2 cytochrome P450, family 2, subfamily d, polypeptide 34

Status: PROVISIONAL

Source sequence(s)

AC118710

Consensus CDS

CCDS37161.1

UniProtKB/TrEMBL

L7N463

Related

ENSMUSP00000105141.2, ENSMUST00000109515.3

Conserved Domains (1) summary

pfam00067
Location:37 → 496

p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

82500164..82505157 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017316570.1 → XP_017172059.1 cytochrome P450, family 2, subfamily d, polypeptide 34 isoform X1

Conserved Domains (1) summary

pfam00067
Location:1 → 421

p450; Cytochrome P450
XM_030248505.1 → XP_030104365.1 cytochrome P450, family 2, subfamily d, polypeptide 34 isoform X4

Conserved Domains (1) summary

pfam00067
Location:37 → 511

p450; Cytochrome P450
XM_030248504.1 → XP_030104364.1 cytochrome P450, family 2, subfamily d, polypeptide 34 isoform X2

Conserved Domains (1) summary

pfam00067
Location:37 → 398

p450; Cytochrome P450
XM_017316571.2 → XP_017172060.1 cytochrome P450, family 2, subfamily d, polypeptide 34 isoform X3

Conserved Domains (1) summary

pfam00067
Location:37 → 332

p450; Cytochrome P450