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    Ankrd31 ankyrin repeat domain 31 [ Mus musculus (house mouse) ]

    Gene ID: 625662, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ankrd31provided by MGI
    Official Full Name
    ankyrin repeat domain 31provided by MGI
    Primary source
    MGI:MGI:5006716
    See related
    Ensembl:ENSMUSG00000109561 AllianceGenome:MGI:5006716
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Involved in homologous chromosome pairing at meiosis; meiotic DNA double-strand break formation involved in reciprocal meiotic recombination; and positive regulation of meiotic DNA double-strand break formation. Located in chromatin. Orthologous to human ANKRD31 (ankyrin repeat domain 31). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 2.4) See more
    Orthologs
    human all
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    Genomic context

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    See Ankrd31 in Genome Data Viewer
    Location:
    13; 13 D1
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (96884797..97046302)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (96748289..96909794)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E748 Neighboring gene STARR-seq mESC enhancer starr_35346 Neighboring gene 3-hydroxy-3-methylglutaryl-Coenzyme A reductase Neighboring gene STARR-seq mESC enhancer starr_35347 Neighboring gene STARR-positive B cell enhancer ABC_E9154 Neighboring gene predicted gene, 33171 Neighboring gene predicted gene, 57606 Neighboring gene STARR-seq mESC enhancer starr_35351 Neighboring gene STARR-seq mESC enhancer starr_35353 Neighboring gene glucosaminyl (N-acetyl) transferase 4, core 2 (beta-1,6-N-acetylglucosaminyltransferase) Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:97735001-97735184 Neighboring gene predicted gene, 41027

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Male Mouse Meiotic Cilium Emanates from the Mother Centriole at Zygotene Prior to Centrosome Duplication. López-Jiménez P, et al. Cells, 2022 Dec 29. PMID 36611937, Free PMC Article
    2. Ankrd31 in Sperm and Epididymal Integrity. Manfrevola F, et al. Front Cell Dev Biol, 2021. PMID 34820371, Free PMC Article
    3. Essential roles of the ANKRD31-REC114 interaction in meiotic recombination and mouse spermatogenesis. Xu J, et al. Proc Natl Acad Sci U S A, 2023 Nov 21. PMID 37976262, Free PMC Article
    4. REC114 Partner ANKRD31 Controls Number, Timing, and Location of Meiotic DNA Breaks. Boekhout M, et al. Mol Cell, 2019 Jun 6. PMID 31003867, Free PMC Article
    5. Mouse ANKRD31 Regulates Spatiotemporal Patterning of Meiotic Recombination Initiation and Ensures Recombination between X and Y Sex Chromosomes. Papanikos F, et al. Mol Cell, 2019 Jun 6. PMID 31000436

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in homologous chromosome pairing at meiosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic DNA double-strand break formation involved in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of meiotic DNA double-strand break formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 31

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370928.1 → NP_001357857.1  ankyrin repeat domain-containing protein 31

      Status: VALIDATED

      Source sequence(s)
      AC154851, AC174082
      UniProtKB/Swiss-Prot
      A0A140LI88, A0A140LIB3
      UniProtKB/TrEMBL
      A0A4W7PWM5
      Related
      ENSMUSP00000146720.2, ENSMUST00000208758.2
      Conserved Domains (5) summary
      COG0666
      Location:424 → 628
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:1163 → 1193
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1167 → 1259
      Ank_2; Ankyrin repeats (3 copies)
      pfam18755
      Location:1694 → 1785
      RAMA; Restriction Enzyme Adenine Methylase Associated
      cl39094
      Location:1233 → 1300
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      96884797..97046302
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247341.1 → XP_030103201.1  ankyrin repeat domain-containing protein 31 isoform X1

      UniProtKB/Swiss-Prot
      A0A140LI88, A0A140LIB3
      UniProtKB/TrEMBL
      A0A4W7PWM5
      Related
      ENSMUSP00000146751.2, ENSMUST00000207464.2
      Conserved Domains (5) summary
      COG0666
      Location:424 → 628
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:1163 → 1193
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1167 → 1259
      Ank_2; Ankyrin repeats (3 copies)
      pfam18755
      Location:1694 → 1785
      RAMA; Restriction Enzyme Adenine Methylase Associated
      cl39094
      Location:1233 → 1300
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A140LI88.2 GenPept UniProtKB/Swiss-Prot:A0A140LI88

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials