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    Ntpcr nucleoside-triphosphatase, cancer-related [ Mus musculus (house mouse) ]

    Gene ID: 66566, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Ntpcrprovided by MGI
    Official Full Name
    nucleoside-triphosphatase, cancer-relatedprovided by MGI
    Primary source
    MGI:MGI:1913816
    See related
    Ensembl:ENSMUSG00000031851 AllianceGenome:MGI:1913816
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310079N02Rik
    Summary
    Predicted to enable ribonucleoside triphosphate phosphatase activity. Predicted to be involved in chromatin looping and chromatin remodeling. Orthologous to human NTPCR (nucleoside-triphosphatase, cancer-related). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in testis adult (RPKM 15.1), bladder adult (RPKM 5.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ntpcr in Genome Data Viewer
    Location:
    8 E2; 8 73.65 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (126456724..126474974)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (125729975..125748235)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39282 Neighboring gene STARR-seq mESC enhancer starr_23044 Neighboring gene STARR-seq mESC enhancer starr_23045 Neighboring gene predicted gene, 39283 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:128265368-128265564 Neighboring gene predicted gene, 39285 Neighboring gene pecanex homolog 2 Neighboring gene predicted gene, 39284

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables membrane scission GTPase motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables ribonucleoside triphosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribonucleoside triphosphate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cancer-related nucleoside-triphosphatase homolog
    Names
    NTPase
    nucleoside triphosphate phosphohydrolase
    nucleoside-triphosphatase C1orf57 homolog
    NP_001297617.1
    NP_079912.1
    XP_006531346.2
    XP_006531348.1
    XP_006531349.1
    XP_006531350.1
    XP_030099583.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310688.1 → NP_001297617.1  cancer-related nucleoside-triphosphatase homolog isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a portion of the 3' coding region and uses a different 3' terminal exon compared to variant 1. It encodes isoform 2, which is shorter than and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC151909, AK010823, AK086714, BY515428
      Consensus CDS
      CCDS80944.1
      UniProtKB/TrEMBL
      Q8C373
      Related
      ENSMUSP00000069384.6, ENSMUST00000065135.12
      Conserved Domains (2) summary
      smart00382
      Location:3 → 59
      AAA; ATPases associated with a variety of cellular activities
      cl21455
      Location:4 → 106
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_025636.5 → NP_079912.1  cancer-related nucleoside-triphosphatase homolog isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC151909, AK006433, AK010823
      Consensus CDS
      CCDS22781.1
      UniProtKB/Swiss-Prot
      Q9CQA9
      UniProtKB/TrEMBL
      Q9CX79
      Related
      ENSMUSP00000034313.7, ENSMUST00000034313.13
      Conserved Domains (2) summary
      smart00382
      Location:3 → 59
      AAA; ATPases associated with a variety of cellular activities
      pfam03266
      Location:4 → 182
      NTPase_1; NTPase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      126456724..126474974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531285.4 → XP_006531348.1  cancer-related nucleoside-triphosphatase homolog isoform X2

      Conserved Domains (1) summary
      cl38985
      Location:20 → 130
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_030243723.1 → XP_030099583.1  cancer-related nucleoside-triphosphatase homolog isoform X2

      Conserved Domains (1) summary
      cl38985
      Location:20 → 130
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. XM_006531283.4 → XP_006531346.2  cancer-related nucleoside-triphosphatase homolog isoform X1

      UniProtKB/TrEMBL
      Q9CX79
      Conserved Domains (1) summary
      pfam03266
      Location:4 → 148
      NTPase_1

    4. XM_006531286.5 → XP_006531349.1  cancer-related nucleoside-triphosphatase homolog isoform X2

      Conserved Domains (1) summary
      cl38985
      Location:20 → 130
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    5. XM_006531287.4 → XP_006531350.1  cancer-related nucleoside-triphosphatase homolog isoform X2

      Conserved Domains (1) summary
      cl38985
      Location:20 → 130
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQA9.1 GenPept UniProtKB/Swiss-Prot:Q9CQA9

    Gene LinkOut

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