Ckb creatine kinase B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ckbprovided by RGD
Official Full Name: creatine kinase Bprovided by RGD
Primary source: RGD:2357
See related: EnsemblRapid:ENSRNOG00000010872 AllianceGenome:RGD:2357
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ckbb; Ckbr; CPK-B
Summary: Predicted to enable creatine kinase activity and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to estrogen stimulus; cellular response to wortmannin; and intracellular chloride ion homeostasis. Located in dendrite and neuronal cell body. Orthologous to human CKB (creatine kinase B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 2087.7), Heart (RPKM 633.6) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q32

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (136550583..136553464, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (130729420..130732301, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (136142956..136145838, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that the beta-alanine administration was able to inhibit the enzyme pyruvate kinase, cytosolic creatine kinase, and adenylate kinase activities in cerebral cortex, and increase in cerebellum.
Title: Effects of β-alanine administration on selected parameters of oxidative stress and phosphoryltransfer network in cerebral cortex and cerebellum of rats.
These results indicate that Hpca associates with BB-CK and that together they translocate to membrane compartments in a Ca(2+)-dependent manner.
Title: Hippocalcin mediates calcium-dependent translocation of brain-type creatine kinase (BB-CK) in hippocampal neurons.
The expression of CK in cochlear tissues during development may reflect differential requirements for creatine-phosphocreatine buffering to replenish ATP consumed during energy-dependent metabolic processes.
Title: Expression and distribution of creatine transporter and creatine kinase (brain isoform) in developing and mature rat cochlear tissues.
Results suggest that the inhibition of brain creatine kinase activity may be involved in the pathogenesis of pneumococcal meningitis.
Title: Brain creatine kinase activity after meningitis induced by Streptococcus pneumoniae.
report the identity of a 45 kDa imidazoline binding protein to be brain creatine kinase and this enzyme possesses an I2 binding site; findings will undoubtedly contribute to greater understanding of and development of imidazoline therapeutic drugs.
Title: Identification of an imidazoline binding protein: creatine kinase and an imidazoline-2 binding site.
Total and cytosolic creatine kinase activities were significantly inhibited by Lys. The inhibitory effect of Lys on total cysteine kinase activity was totally prevented by reduced glutathione.
Title: Inhibition of creatine kinase activity by lysine in rat cerebral cortex.
Creatin kinase inhibition caused by cystine released from lysosomes could be one of the mechanisms of tissue damage in patients with cystinosis.
Title: Cysteamine prevents inhibition of thiol-containing enzymes caused by cystine or cystine dimethylester loading in rat brain cortex.
Although it is difficult to extrapolate our findings to the human condition, the inhibition of brain CK activity after renal failure may be associated to neuronal loss and may be involved in the pathogenesis of uremic encephalopathy.
Title: Inhibition of brain creatine kinase activity after renal ischemia is attenuated by N-acetylcysteine and deferoxamine administration.
In the cellular micro-environment, brain-type creatine kinase activates the KCC2 function.
Title: Brain-type creatine kinase activates neuron-specific K+-Cl- co-transporter KCC2.
The increase in CKB protein during cerebellar postnatal development was coincident with that of the ubiquitous mitochondrial CK protein and mRNA, indicating that a phosphocreatine energy shuttle probably exists for ATP regeneration in the cerebellum.
Title: Expression of creatine kinase isoenzyme genes during postnatal development of rat brain cerebellum: evidence for transcriptional regulation.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D6Wox13 (e-PCR)
- UniSTS:118104

D6Wox15 (e-PCR)
- UniSTS:118105

D6Mit6 (e-PCR), detects polymorphism
- UniSTS:119389

RH127492 (e-PCR)
- UniSTS:210802

Egfr-rs (e-PCR), detects polymorphism
- UniSTS:142973

NoName (e-PCR)
- UniSTS:546700

Ckb (e-PCR), detects polymorphism
- UniSTS:546700

D6Arb1 (e-PCR)
- UniSTS:239315

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables creatine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables creatine kinase activity	IEA Inferred from Electronic Annotation more info
enables creatine kinase activity	ISO Inferred from Sequence Orthology more info
enables creatine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to estrogen stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to wortmannin	IEP Inferred from Expression Pattern more info	PubMed
involved_in cerebellum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in futile creatine cycle	IEA Inferred from Electronic Annotation more info
involved_in futile creatine cycle	ISO Inferred from Sequence Orthology more info
involved_in intracellular chloride ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphocreatine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphocreatine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphocreatine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in substantia nigra development	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: creatine kinase B-type

Names: B-CK; brain creatine kinase; creatine kinase B chain; creatine kinase, brain; creatine phosphokinase M-type

NP_036661.3

EC 2.7.3.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.