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    Timm8a1 translocase of inner mitochondrial membrane 8A1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84383, updated on 9-Dec-2024

    Summary

    Official Symbol
    Timm8a1provided by RGD
    Official Full Name
    translocase of inner mitochondrial membrane 8A1provided by RGD
    Primary source
    RGD:621801
    See related
    EnsemblRapid:ENSRNOG00000064119 AllianceGenome:RGD:621801
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    DDP; Ddp1; Timm8a
    Summary
    Enables zinc ion binding activity. Involved in protein targeting to mitochondrion. Predicted to be located in mitochondrial intermembrane space. Predicted to be part of mitochondrial intermembrane space protein transporter complex. Human ortholog(s) of this gene implicated in deafness-dystonia-optic neuronopathy syndrome and dystonia. Orthologous to human TIMM8A (translocase of inner mitochondrial membrane 8A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 317.3), Heart (RPKM 287.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Timm8a1 in Genome Data Viewer
    Location:
    Xq32
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (102011206..102015444, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (97717932..97722170, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (105351714..105355722, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene TATA-box binding protein associated factor 7-like Neighboring gene U6 spliceosomal RNA Neighboring gene transfer RNA aspartic acid (anticodon AUC) 1 Neighboring gene Bruton tyrosine kinase Neighboring gene ribosomal protein L36A

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General protein information

    Preferred Names
    mitochondrial import inner membrane translocase subunit Tim8 A
    Names
    deafness dystonia protein 1 homolog
    translocase of inner mitochondrial membrane 8 homolog A1
    translocase of inner mitochondrial membrane 8 homolog a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053370.4NP_445822.1  mitochondrial import inner membrane translocase subunit Tim8 A

      See identical proteins and their annotated locations for NP_445822.1

      Status: VALIDATED

      Source sequence(s)
      BC060552, JAXUCZ010000021
      UniProtKB/Swiss-Prot
      Q9WVA1
      UniProtKB/TrEMBL
      A6IVF6
      Related
      ENSRNOP00000084461.1, ENSRNOT00000108899.2
      Conserved Domains (1) summary
      pfam02953
      Location:2181
      zf-Tim10_DDP; Tim10/DDP family zinc finger

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      102011206..102015444 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)