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    Cast calpastatin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25403, updated on 3-Dec-2024

    Summary

    Official Symbol
    Castprovided by RGD
    Official Full Name
    calpastatinprovided by RGD
    Primary source
    RGD:2278
    See related
    EnsemblRapid:ENSRNOG00000010286 AllianceGenome:RGD:2278
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables calcium-dependent cysteine-type endopeptidase inhibitor activity and protease binding activity. Involved in several processes, including animal organ regeneration; myoblast fusion; and skeletal muscle atrophy. Located in membrane and postsynaptic density. Used to study brain ischemia. Biomarker of alcohol use disorder; hypertension; and muscular atrophy. Human ortholog(s) of this gene implicated in PLACK syndrome; Parkinson's disease; autoimmune disease (multiple); congenital myasthenic syndrome 1A; and vasculitis. Orthologous to human CAST (calpastatin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 280.0), Spleen (RPKM 229.5) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cast in Genome Data Viewer
    Location:
    2q11
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (5707633..5817213, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (3973112..4082658, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (1452111..1561669, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548635 Neighboring gene endoplasmic reticulum aminopeptidase 1 Neighboring gene uncharacterized LOC134485561 Neighboring gene RNA, U6 small nuclear 1303 Neighboring gene proprotein convertase subtilisin/kexin type 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC108997

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    calpastatin
    Names
    calpain inhibitor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033715.1NP_001028887.1  calpastatin isoform b

      See identical proteins and their annotated locations for NP_001028887.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      BC091239
      UniProtKB/Swiss-Prot
      A5GXY4, A5GXY5, A5GXY6, A5GXY7, A5GXY8, A5GXY9, A5GXZ7, O55151, O55152, O55153, P27321, Q5BK19, Q99MG1, Q99MG2
      UniProtKB/TrEMBL
      A0A0G2JSY2
      Conserved Domains (1) summary
      pfam00748
      Location:233357
      Calpain_inhib; Calpain inhibitor
    2. NM_001033716.1NP_001028888.1  calpastatin isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two in-frame exons compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AF346597, BC091239, Y13589
      UniProtKB/Swiss-Prot
      A5GXY4, A5GXY5, A5GXY6, A5GXY7, A5GXY8, A5GXY9, A5GXZ7, O55151, O55152, O55153, P27321, Q5BK19, Q99MG1, Q99MG2
      UniProtKB/TrEMBL
      D3ZL24
      Related
      ENSRNOP00000058756.3, ENSRNOT00000062052.6
      Conserved Domains (1) summary
      pfam00748
      Location:210334
      Calpain_inhib; Calpain inhibitor
    3. NM_053295.2NP_445747.2  calpastatin isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      BC091239, Y13588
      UniProtKB/Swiss-Prot
      A5GXY4, A5GXY5, A5GXY6, A5GXY7, A5GXY8, A5GXY9, A5GXZ7, O55151, O55152, O55153, P27321, Q5BK19, Q99MG1, Q99MG2
      Related
      ENSRNOP00000058759.3, ENSRNOT00000062055.7
      Conserved Domains (1) summary
      pfam00748
      Location:271395
      Calpain_inhib; Calpain inhibitor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      5707633..5817213 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101793.2XP_038957721.1  calpastatin isoform X7

      UniProtKB/Swiss-Prot
      A5GXY4, A5GXY5, A5GXY6, A5GXY7, A5GXY8, A5GXY9, A5GXZ7, O55151, O55152, O55153, P27321, Q5BK19, Q99MG1, Q99MG2
      Conserved Domains (1) summary
      pfam00748
      Location:197319
      Calpain_inhib; Calpain inhibitor
    2. XM_039101792.2XP_038957720.1  calpastatin isoform X5

      UniProtKB/Swiss-Prot
      A5GXY4, A5GXY5, A5GXY6, A5GXY7, A5GXY8, A5GXY9, A5GXZ7, O55151, O55152, O55153, P27321, Q5BK19, Q99MG1, Q99MG2
      UniProtKB/TrEMBL
      D4A129
      Related
      ENSRNOP00000091066.1, ENSRNOT00000100619.2
      Conserved Domains (1) summary
      pfam00748
      Location:220342
      Calpain_inhib; Calpain inhibitor
    3. XM_039101791.2XP_038957719.1  calpastatin isoform X1

      UniProtKB/Swiss-Prot
      A5GXY4, A5GXY5, A5GXY6, A5GXY7, A5GXY8, A5GXY9, A5GXZ7, O55151, O55152, O55153, P27321, Q5BK19, Q99MG1, Q99MG2
      Related
      ENSRNOP00000058758.3, ENSRNOT00000062054.7
      Conserved Domains (1) summary
      pfam00748
      Location:258380
      Calpain_inhib; Calpain inhibitor
    4. XM_006231699.5XP_006231761.1  calpastatin isoform X3

      UniProtKB/Swiss-Prot
      A5GXY4, A5GXY5, A5GXY6, A5GXY7, A5GXY8, A5GXY9, A5GXZ7, O55151, O55152, O55153, P27321, Q5BK19, Q99MG1, Q99MG2
      Conserved Domains (1) summary
      pfam00748
      Location:248372
      Calpain_inhib; Calpain inhibitor
    5. XM_006231698.5XP_006231760.1  calpastatin isoform X2

      UniProtKB/Swiss-Prot
      A5GXY4, A5GXY5, A5GXY6, A5GXY7, A5GXY8, A5GXY9, A5GXZ7, O55151, O55152, O55153, P27321, Q5BK19, Q99MG1, Q99MG2
      UniProtKB/TrEMBL
      A0A8I6GK55
      Related
      ENSRNOP00000093165.1, ENSRNOT00000108912.2
      Conserved Domains (1) summary
      pfam00748
      Location:256380
      Calpain_inhib; Calpain inhibitor
    6. XM_063281352.1XP_063137422.1  calpastatin isoform X6

      UniProtKB/TrEMBL
      A6I4E3
      Related
      ENSRNOP00000014709.8, ENSRNOT00000014709.10
    7. XM_063281351.1XP_063137421.1  calpastatin isoform X4

      UniProtKB/Swiss-Prot
      A5GXY4, A5GXY5, A5GXY6, A5GXY7, A5GXY8, A5GXY9, A5GXZ7, O55151, O55152, O55153, P27321, Q5BK19, Q99MG1, Q99MG2
    8. XM_063281353.1XP_063137423.1  calpastatin isoform X8

      UniProtKB/TrEMBL
      A6I4E2
    9. XM_017590647.3XP_017446136.1  calpastatin isoform X9