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    Snap23 synaptosome associated protein 23 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64630, updated on 9-Dec-2024

    Summary

    Official Symbol
    Snap23provided by RGD
    Official Full Name
    synaptosome associated protein 23provided by RGD
    Primary source
    RGD:620221
    See related
    EnsemblRapid:ENSRNOG00000050552 AllianceGenome:RGD:620221
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables SNAP receptor activity and syntaxin binding activity. Involved in several processes, including exocytic insertion of neurotransmitter receptor to postsynaptic membrane; regulation of exocytosis; and vesicle-mediated transport in synapse. Located in terminal bouton. Part of SNARE complex. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynapse. Orthologous to human SNAP23 (synaptosome associated protein 23). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 334.0), Spleen (RPKM 216.6) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Snap23 in Genome Data Viewer
    Location:
    3q35
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (127966184..127999929)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (107514088..107546177)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (112333972..112362960)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA15 Neighboring gene calpain 3 Neighboring gene zinc finger protein 106 Neighboring gene leucine rich repeat containing 57 Neighboring gene HAUS augmin like complex subunit 2 Neighboring gene StAR-related lipid transfer domain containing 9 Neighboring gene codanin 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables SNAP receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables syntaxin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables syntaxin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in GABA-ergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of SNARE complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of SNARE complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in azurophil granule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in azurophil granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in specific granule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in specific granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in terminal bouton HDA PubMed 

    General protein information

    Preferred Names
    synaptosomal-associated protein 23
    Names
    SNAP-23
    synaptosomal-associated protein, 23 kD
    vesicle-membrane fusion protein SNAP-23

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429469.1NP_001416398.1  synaptosomal-associated protein 23 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      M0R4V3
    2. NM_001429470.1NP_001416399.1  synaptosomal-associated protein 23 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      A0JPL8, O70377
    3. NM_022689.2NP_073180.1  synaptosomal-associated protein 23 isoform 1

      See identical proteins and their annotated locations for NP_073180.1

      Status: PROVISIONAL

      Source sequence(s)
      BC127494
      UniProtKB/Swiss-Prot
      A0JPL8, O70377
      Related
      ENSRNOP00000091304.1, ENSRNOT00000096953.2
      Conserved Domains (3) summary
      cd15884
      Location:148206
      SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
      cd15895
      Location:975
      SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
      pfam00835
      Location:86146
      SNAP-25; SNAP-25 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      127966184..127999929
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105811.2XP_038961739.1  synaptosomal-associated protein 23 isoform X1

      Related
      ENSRNOP00000064401.3, ENSRNOT00000074392.4
      Conserved Domains (3) summary
      cd15884
      Location:159217
      SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
      cd15895
      Location:975
      SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
      pfam00835
      Location:100157
      SNAP-25; SNAP-25 family
    2. XM_039105813.2XP_038961741.1  synaptosomal-associated protein 23 isoform X2

      Conserved Domains (3) summary
      cd15884
      Location:148206
      SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
      cd15895
      Location:975
      SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
      pfam00835
      Location:86146
      SNAP-25; SNAP-25 family
    3. XM_063284525.1XP_063140595.1  synaptosomal-associated protein 23 isoform X2

      UniProtKB/Swiss-Prot
      A0JPL8, O70377
    4. XM_039105812.2XP_038961740.1  synaptosomal-associated protein 23 isoform X1

      UniProtKB/TrEMBL
      M0R4V3
      Conserved Domains (3) summary
      cd15884
      Location:159217
      SNARE_SNAP23C; C-terminal SNARE motif of SNAP23
      cd15895
      Location:975
      SNARE_SNAP23N; N-terminal SNARE motif of SNAP23
      pfam00835
      Location:100157
      SNAP-25; SNAP-25 family
    5. XM_063284526.1XP_063140596.1  synaptosomal-associated protein 23 isoform X2

      UniProtKB/Swiss-Prot
      A0JPL8, O70377