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    Masp1 MBL associated serine protease 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64023, updated on 27-Nov-2024

    Summary

    Official Symbol
    Masp1provided by RGD
    Official Full Name
    MBL associated serine protease 1provided by RGD
    Primary source
    RGD:620213
    See related
    EnsemblRapid:ENSRNOG00000001827 AllianceGenome:RGD:620213
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Masp3; Masp1/3
    Summary
    Enables several functions, including calcium-dependent protein binding activity; protein homodimerization activity; and serine-type endopeptidase activity. Predicted to be involved in complement activation, lectin pathway; negative regulation of complement activation; and zymogen activation. Located in extracellular space. Human ortholog(s) of this gene implicated in 3MC syndrome 1. Orthologous to human MASP1 (MBL associated serine protease 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 252.8), Muscle (RPKM 81.6) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Masp1 in Genome Data Viewer
    Location:
    11q23
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (90839081..90909922)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (77334794..77405271)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (80736424..80806278)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene CTD small phosphatase 1, pseudogene 1 Neighboring gene uncharacterized LOC134481100 Neighboring gene receptor (chemosensory) transporter protein 4 Neighboring gene uncharacterized LOC134481025 Neighboring gene uncharacterized LOC134481026 Neighboring gene receptor (chemosensory) transporter protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calcium-dependent protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in complement activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in complement activation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in complement activation, lectin pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in complement activation, lectin pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in complement activation, lectin pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in complement activation, lectin pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of complement activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mannan-binding lectin serine protease 1
    Names
    MASP-1
    complement factor MASP-3
    complement-activating component of Ra-reactive factor
    mannan-binding lectin serine peptidase 1
    mannan-binding lectin serine protease 2-like
    mannose-binding lectin-associated serine protease 1
    mannose-binding protein associated serine protease-1
    mannose-binding protein-associated serine protease
    ra-reactive factor serine protease p100
    raRF
    serine protease 5
    serine protease MASP1
    NP_071593.2
    XP_006248588.1
    XP_008767026.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022257.2NP_071593.2  mannan-binding lectin serine protease 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      O09020, Q5U365, Q8CG41, Q8CHN8, Q9JJS9
      UniProtKB/TrEMBL
      A0A0H2UHA1
      Related
      ENSRNOP00000079792.1, ENSRNOT00000094154.2
      Conserved Domains (6) summary
      cd00033
      Location:306368
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      PHA02639
      Location:305438
      PHA02639; EEV host range protein; Provisional
      cd00041
      Location:33142
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00190
      Location:454699
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00431
      Location:190299
      CUB; CUB domain
      pfam14670
      Location:158186
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      90839081..90909922
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248526.5XP_006248588.1  mannan-binding lectin serine protease 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZL57
      Related
      ENSRNOP00000078578.2, ENSRNOT00000111260.2
      Conserved Domains (6) summary
      cd00033
      Location:306368
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00020
      Location:454715
      Tryp_SPc; Trypsin-like serine protease
      cd00041
      Location:33142
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00190
      Location:455716
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00431
      Location:190299
      CUB; CUB domain
      pfam14670
      Location:158186
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    2. XM_008768804.4XP_008767026.1  mannan-binding lectin serine protease 1 isoform X2

      See identical proteins and their annotated locations for XP_008767026.1

      UniProtKB/TrEMBL
      A6JS17
      Related
      ENSRNOP00000044812.3, ENSRNOT00000047678.6
      Conserved Domains (4) summary
      cd00033
      Location:306368
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd00041
      Location:33142
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00431
      Location:190299
      CUB; CUB domain
      pfam14670
      Location:158186
      FXa_inhibition; Coagulation Factor Xa inhibitory site