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    Drp2 dystrophin related protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 66027, updated on 3-Dec-2024

    Summary

    Official Symbol
    Drp2provided by RGD
    Official Full Name
    dystrophin related protein 2provided by RGD
    Primary source
    RGD:621750
    See related
    EnsemblRapid:ENSRNOG00000026704 AllianceGenome:RGD:621750
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    DRP-2
    Summary
    Predicted to enable zinc ion binding activity. Involved in synapse organization. Located in dendrite. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human DRP2 (dystrophin related protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 70.7), Adrenal (RPKM 36.7) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Drp2 in Genome Data Viewer
    Location:
    Xq32
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (101900743..101951403)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (97607577..97658117)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (105239623..105290233)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 35A Neighboring gene centromere protein I Neighboring gene TATA-box binding protein associated factor 7-like Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in central nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in synaptic signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    dystrophin-related protein 2
    Names
    dystrophin-related protein 2 A-form

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395076.1NP_001382005.1  dystrophin-related protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      G3V971, Q9EPA0
      UniProtKB/TrEMBL
      A0A8L2R2Z3
      Conserved Domains (4) summary
      cd00176
      Location:111339
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:357385
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:608656
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16248
      Location:422583
      EFh_DRP-2; EF-hand-like motif found in dystrophin-related protein 2 (DRP-2)
    2. NM_023971.2NP_076461.2  dystrophin-related protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      G3V971, Q9EPA0
      UniProtKB/TrEMBL
      A0A8L2R2Z3
      Related
      ENSRNOP00000037371.3, ENSRNOT00000039864.5
      Conserved Domains (4) summary
      cd00176
      Location:111339
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:357385
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:608656
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16248
      Location:422583
      EFh_DRP-2; EF-hand-like motif found in dystrophin-related protein 2 (DRP-2)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      101900743..101951403
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008773433.4XP_008771655.1  dystrophin-related protein 2 isoform X1

      See identical proteins and their annotated locations for XP_008771655.1

      UniProtKB/Swiss-Prot
      G3V971, Q9EPA0
      UniProtKB/TrEMBL
      A0A8L2R2Z3
      Conserved Domains (4) summary
      cd00176
      Location:111339
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:357385
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:608656
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16248
      Location:422583
      EFh_DRP-2; EF-hand-like motif found in dystrophin-related protein 2 (DRP-2)
    2. XM_063280292.1XP_063136362.1  dystrophin-related protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8L2R2Z3
      Related
      ENSRNOP00000070220.3, ENSRNOT00000085693.3
    3. XM_063280291.1XP_063136361.1  dystrophin-related protein 2 isoform X1

      UniProtKB/Swiss-Prot
      G3V971, Q9EPA0
      UniProtKB/TrEMBL
      A0A8L2R2Z3
    4. XM_008773436.4XP_008771658.1  dystrophin-related protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8L2R2Z3
      Conserved Domains (5) summary
      cd00176
      Location:33261
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:279307
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:530578
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      pfam09068
      Location:308426
      EF-hand_2; EF hand
      pfam09069
      Location:430521
      EF-hand_3; EF-hand