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    Rnf181 ring finger protein 181 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297337, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rnf181provided by RGD
    Official Full Name
    ring finger protein 181provided by RGD
    Primary source
    RGD:1359698
    See related
    EnsemblRapid:ENSRNOG00000012035 AllianceGenome:RGD:1359698
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein autoubiquitination. Predicted to be active in cytoplasm. Orthologous to human RNF181 (ring finger protein 181). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 390.7), Testes (RPKM 275.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rnf181 in Genome Data Viewer
    Location:
    4q32
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (105972778..105979624, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (104414586..104421433, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (100222087..100228809, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene surfactant protein B Neighboring gene ubiquitin specific peptidase 39 Neighboring gene similar to human chromosome 2 open reading frame 68 Neighboring gene transmembrane protein 150A Neighboring gene vesicle-associated membrane protein 5 Neighboring gene uncharacterized LOC134486592 Neighboring gene vesicle-associated membrane protein 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Negative Regulation of CARD11 Signaling and Lymphoma Cell Survival by the E3 Ubiquitin Ligase RNF181. Pedersen SM, et al. Mol Cell Biol, 2015 Dec 28. PMID 26711259, Free PMC Article
    2. Protein microarray characterization of the S-nitrosoproteome. Lee YI, et al. Mol Cell Proteomics, 2014 Jan. PMID 24105792, Free PMC Article
    3. Oxidant-induced Interprotein Disulfide Formation in Cardiac Protein DJ-1 Occurs via an Interaction with Peroxiredoxin 2. Fernandez-Caggiano M, et al. J Biol Chem, 2016 May 6. PMID 26945066, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94464

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF181
    Names
    RING-type E3 ubiquitin transferase RNF181
    NP_001007648.1
    XP_038963245.1
    XP_038963247.1
    XP_063141849.1
    XP_063141850.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007647.1 → NP_001007648.1  E3 ubiquitin-protein ligase RNF181

      See identical proteins and their annotated locations for NP_001007648.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079313
      UniProtKB/Swiss-Prot
      Q6AXU4
      UniProtKB/TrEMBL
      A6IAB1, A6IAB2
      Related
      ENSRNOP00000016699.3, ENSRNOT00000016699.8
      Conserved Domains (1) summary
      cd16669
      Location:87 → 132
      RING-H2_RNF181; RING finger, H2 subclass, found in RING finger protein 181 (RNF181) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      105972778..105979624 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107317.1 → XP_038963245.1  E3 ubiquitin-protein ligase RNF181 isoform X2

      Conserved Domains (1) summary
      cd16669
      Location:55 → 100
      RING-H2_RNF181; RING finger, H2 subclass, found in RING finger protein 181 (RNF181) and similar proteins

    2. XM_039107319.2 → XP_038963247.1  E3 ubiquitin-protein ligase RNF181 isoform X3

      UniProtKB/TrEMBL
      A6IAB3
      Conserved Domains (1) summary
      cd16669
      Location:40 → 85
      RING-H2_RNF181; RING finger, H2 subclass, found in RING finger protein 181 (RNF181) and similar proteins

    3. XM_063285779.1 → XP_063141849.1  E3 ubiquitin-protein ligase RNF181 isoform X1

      UniProtKB/Swiss-Prot
      Q6AXU4
      UniProtKB/TrEMBL
      A6IAB1, A6IAB2

    4. XM_063285780.1 → XP_063141850.1  E3 ubiquitin-protein ligase RNF181 isoform X3

      UniProtKB/TrEMBL
      A6IAB3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AXU4.1 GenPept UniProtKB/Swiss-Prot:Q6AXU4

    Gene LinkOut

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