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    Kifbp kinesin family binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 606294, updated on 27-Nov-2024

    Summary

    Official Symbol
    Kifbpprovided by RGD
    Official Full Name
    kinesin family binding proteinprovided by RGD
    Primary source
    RGD:1593126
    See related
    EnsemblRapid:ENSRNOG00000000395 AllianceGenome:RGD:1593126
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kbp; Kif1bp
    Summary
    Predicted to enable kinesin binding activity and protein sequestering activity. Predicted to be involved in microtubule cytoskeleton organization; mitochondrion transport along microtubule; and plasma membrane bounded cell projection organization. Predicted to act upstream of or within in utero embryonic development. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in Goldberg-Shprintzen syndrome. Orthologous to human KIFBP (kinesin family binding protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 225.3), Kidney (RPKM 130.5) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Kifbp in Genome Data Viewer
    Location:
    20q11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (31055625..31075232, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (30512899..30532504, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (32191731..32211295, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene serglycin Neighboring gene large ribosomal subunit protein eL39-like Neighboring gene uncharacterized LOC134483921 Neighboring gene DExD-box helicase 21 Neighboring gene DExD-box helicase 50

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables kinesin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinesin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein sequestering activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein sequestering activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in central nervous system projection neuron axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrion transport along microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitochondrion transport along microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrion transport along microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuron projection maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in transport along microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    KIF-binding protein
    Names
    KIF1 binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031627.1NP_001026797.1  KIF-binding protein

      See identical proteins and their annotated locations for NP_001026797.1

      Status: VALIDATED

      Source sequence(s)
      BC060521, BC098692
      UniProtKB/Swiss-Prot
      Q4G074
      UniProtKB/TrEMBL
      A6K453, G3V614
      Related
      ENSRNOP00000000444.6, ENSRNOT00000000444.9
      Conserved Domains (1) summary
      pfam12309
      Location:243609
      KBP_C; KIF-1 binding protein C terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      31055625..31075232 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099049.2XP_038954977.1  KIF-binding protein isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZUA6
      Related
      ENSRNOP00000082090.1, ENSRNOT00000103307.2
      Conserved Domains (1) summary
      pfam12309
      Location:243293
      KBP_C; KIF-1 binding protein C terminal
    2. XM_063279488.1XP_063135558.1  KIF-binding protein isoform X1