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    Dhx36 DEAH-box helicase 36 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310461, updated on 27-Nov-2024

    Summary

    Official Symbol
    Dhx36provided by RGD
    Official Full Name
    DEAH-box helicase 36provided by RGD
    Primary source
    RGD:1308767
    See related
    EnsemblRapid:ENSRNOG00000014599 AllianceGenome:RGD:1308767
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    G4R1
    Summary
    Enables pre-miRNA binding activity. Involved in positive regulation of dendritic spine morphogenesis; positive regulation of gene expression; and positive regulation of intracellular mRNA localization. Located in axon; dendrite; and perikaryon. Orthologous to human DHX36 (DEAH-box helicase 36). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 198.3), Thymus (RPKM 189.5) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Dhx36 in Genome Data Viewer
    Location:
    2q31
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (149006089..149044192, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (146856469..146894577, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (152785844..152824549, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene Rho guanine nucleotide exchange factor 26 Neighboring gene uncharacterized LOC134485922 Neighboring gene uncharacterized LOC120100834 Neighboring gene G protein-coupled receptor 149 Neighboring gene RNA, U6 small nuclear 1286

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent activity, acting on DNA ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables G-quadruplex DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G-quadruplex DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables G-quadruplex DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables G-quadruplex RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G-quadruplex RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables G-quadruplex RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables double-stranded DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables forked DNA-dependent helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables four-way junction helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA 3'-UTR AU-rich region binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA 3'-UTR AU-rich region binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA 3'-UTR binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables mRNA 5'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA 5'-UTR binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables pre-miRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables single-stranded 3'-5' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables telomerase RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables telomerase RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in 3'-UTR-mediated mRNA destabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G-quadruplex DNA unwinding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in G-quadruplex DNA unwinding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in RNA secondary structure unwinding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in RNA secondary structure unwinding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to UV ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to arsenite ion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ossification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical NF-kappaB signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cardioblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cardioblast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytoplasmic translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of hematopoietic progenitor cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interferon-alpha production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of intracellular mRNA localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mRNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mRNA 3'-end processing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of myeloid dendritic cell cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of telomere maintenance via telomere lengthening ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription initiation by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription initiation by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of embryonic development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of mRNA stability ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mRNA stability ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of transcription by RNA polymerase III ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase III ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within response to exogenous dsRNA ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spermatogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in telomerase RNA stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome, telomeric region ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ATP-dependent DNA/RNA helicase DHX36
    Names
    ATP-dependent RNA helicase DHX36
    DEAD/H box polypeptide 36
    DEAH (Asp-Glu-Ala-His) box polypeptide 36
    DEAH-box protein 36
    G4-resolvase-1
    MLE-like protein 1
    RNA helicase associated with AU-rich element protein
    probable ATP-dependent RNA helicase DHX36
    NP_001101148.1
    XP_008759269.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107678.3NP_001101148.1  ATP-dependent DNA/RNA helicase DHX36

      See identical proteins and their annotated locations for NP_001101148.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      D4A2Z8
      UniProtKB/TrEMBL
      A0A8I6A6W1
      Related
      ENSRNOP00000019824.5, ENSRNOT00000019824.8
      Conserved Domains (1) summary
      COG1643
      Location:187893
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      149006089..149044192 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008761047.4XP_008759269.1  ATP-dependent DNA/RNA helicase DHX36 isoform X1

      Conserved Domains (4) summary
      smart00487
      Location:202384
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:668752
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:216361
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00271
      Location:470598
      Helicase_C; Helicase conserved C-terminal domain

    RNA

    1. XR_005500288.2 RNA Sequence

    2. XR_351724.5 RNA Sequence