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    Srp54a signal recognition particle 54A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116650, updated on 9-Dec-2024

    Summary

    Official Symbol
    Srp54aprovided by RGD
    Official Full Name
    signal recognition particle 54Aprovided by RGD
    Primary source
    RGD:621390
    See related
    EnsemblRapid:ENSRNOG00000032776 AllianceGenome:RGD:621390
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Srp54
    Summary
    Predicted to enable several functions, including 7S RNA binding activity; endoplasmic reticulum signal peptide binding activity; and guanyl ribonucleotide binding activity. Predicted to contribute to GTPase activity. Predicted to be involved in several processes, including SRP-dependent cotranslational protein targeting to membrane; exocrine pancreas development; and neutrophil chemotaxis. Predicted to be located in cytoplasm and nucleus. Predicted to be part of signal recognition particle, endoplasmic reticulum targeting. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in severe congenital neutropenia 8. Orthologous to human SRP54 (signal recognition particle 54). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 181.5), Adrenal (RPKM 152.2) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Srp54a in Genome Data Viewer
    Location:
    6q23
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (78322308..78362017)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (72587584..72626878)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (75996629..76035768)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene cofilin 2 Neighboring gene bromodomain adjacent to zinc finger domain, 1A Neighboring gene uncharacterized LOC108351236 Neighboring gene U6 spliceosomal RNA Neighboring gene RIKEN cDNA 2700097009 gene like Neighboring gene uncharacterized LOC134479210 Neighboring gene family with sequence similarity 177, member A1 Neighboring gene protein phosphatase 2, regulatory subunit B'', gamma Neighboring gene protein only RNase P catalytic subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 7S RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 7S RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables 7S RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables endoplasmic reticulum signal peptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables endoplasmic reticulum signal peptide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribonucleoprotein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    NOT located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of signal recognition particle, endoplasmic reticulum targeting IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of signal recognition particle, endoplasmic reticulum targeting IEA
    Inferred from Electronic Annotation
    more info
     
    part_of signal recognition particle, endoplasmic reticulum targeting ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    signal recognition particle subunit SRP54
    Names
    signal recognition particle 54 kDa protein
    NP_446323.1
    XP_006240159.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053871.1NP_446323.1  signal recognition particle subunit SRP54

      See identical proteins and their annotated locations for NP_446323.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079117
      UniProtKB/Swiss-Prot
      Q6AYB5
      UniProtKB/TrEMBL
      A0A8I6A4J0
      Related
      ENSRNOP00000104350.1, ENSRNOT00000131173.1
      Conserved Domains (1) summary
      TIGR01425
      Location:2430
      SRP54_euk; signal recognition particle protein SRP54

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      78322308..78362017
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006240097.5XP_006240159.1  signal recognition particle subunit SRP54 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A4J0
      Related
      ENSRNOP00000085749.1, ENSRNOT00000098782.2
      Conserved Domains (4) summary
      COG0541
      Location:2440
      Ffh; Signal recognition particle GTPase [Intracellular trafficking, secretion, and vesicular transport]
      pfam00448
      Location:102294
      SRP54; SRP54-type protein, GTPase domain
      pfam02881
      Location:683
      SRP54_N; SRP54-type protein, helical bundle domain
      pfam02978
      Location:326385
      SRP_SPB; Signal peptide binding domain